Search review questions

Sensitivity (test accuracy for detecting enamel caries) · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or… · Up to 3 months between index test and reference standard (in vivo studies)

Mean dmft · Preschool children attending Al Ain pediatric dentistry department · Overall

Radiographic proximal caries lesion progression · Patients with non-cavitated proximal caries lesions · Longest available follow-up

Dental caries prevalence · General population (children and adults) in East Africa · Eritrea

Diagnostic accuracy for proximal caries detection (caries detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo) · Caries detection level

Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Overall

Diagnostic accuracy for proximal caries detection (1/3 dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · 1/3 dentin detection level

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Setting: in vitro (non-CBCT)

Specificity (COE plus vital rinsing arm) · OSCC or OPMD symptom-free individuals with tobacco habits

Dental caries prevalence · General population in Ethiopia (all ages, age range 6-100 years) · Amhara

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious… · 6-36 months, Deep lesions, primary dentition

Patient/dentist satisfaction · Patients with dental fluorosis

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · Dentin detection level

Diagnostic accuracy: analogue versus CBCT (within-person, not pooled) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies)

Diagnostic accuracy: in vitro versus in vivo comparison · Asymptomatic children or adults presenting for clinical examination (in vivo studies), or extracted teeth of children… · Up to 3 months between index test and reference standard (in vivo studies), Study setting (in vitro vs in vivo)

Costs: direct cost of treatment · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)

Safety issues (adverse events) · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious…

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Multivariable-adjusted

Dental caries prevalence · Children with cerebral palsy in Dubai · Overall

Outcome NR · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance…

Gingivitis · School children aged 3-12 years in Sharjah clinic · Overall

Participant acceptance/satisfaction · Dental patients undergoing restorative treatment (no age or gender restriction) · Pit and fissure sealing (permanent molars)

Overall survival, induction platinum + 5-fluorouracil prior to radiotherapy vs radiotherapy alone · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Childhood dental caries · Children in cross-sectional studies · Sensitivity: excluded Julihn et al. 2009

Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Ethnicity: Caucasian

Secondary caries · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6… · Follow-up >= 3 years, Split-mouth trials

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Crude

Gingival index (GI) · Adults undergoing orthodontic treatment · 6 to 12 weeks, Adults

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · Caries detection level

Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Ethnicity: Asian

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces

Number of decayed teeth · Adults (general and hospital populations assessed in case-control studies)

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · Caries detection level

Mean DMFT · School children aged 11-17 years in Sharjah · Overall

Diagnostic accuracy for proximal caries detection (1/3 dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · 1/3 dentin detection level

Molar-incisor hypomineralization prevalence · School children aged 8-12 years in Dubai public schools · Females

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Digital

Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances · 12-24 months follow-up

Childhood dental caries · Children in cross-sectional studies · Sensitivity: excluded Majorana et al. 2014

Radiographic proximal caries lesion progression · Patients with non-cavitated proximal caries lesions · Longest available follow-up

Specificity for detection of enamel caries · Asymptomatic children or adults presenting for clinical examination (in vivo studies), or extracted teeth of children… · Up to 3 months between index test and reference standard (in vivo studies)

Dental caries prevalence · General population in Ethiopia (all ages, age range 6-100 years) · Others (Oromia, Harar town, SNNPR)

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Dentine-caries (D3) prevalence high >=35% or unreported (non-CBCT)

Sensitivity · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or… · Up to 3 months between index test and reference standard (in vivo studies)

Water samples with fluoride concentration above the acceptable range · Region: South Brazil

Disease-free survival, induction platinum + 5-fluorouracil prior to radiotherapy vs radiotherapy alone · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Dental caries prevalence · Rwanda

Diagnostic accuracy for occlusal caries detection at the 1/3 dentin caries detection level (Ekstrand; D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · Caries detection level