Search review questions

Frequency of mouth cleaning · Adult residents of slums and non-slum urban settings of LMICs · Cross-sectional, Slum/disadvantaged vs non-slum/urban

White spot lesion rate and volume · Patients undergoing fixed orthodontic treatment · 8 weeks after bonding

Caries severity (d1 + mfs >= 5) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… · Children assessed at 4 yrs

Salivary IL-8 level (pg/mL) · Children and young adults (3-25 years)

Enamel demineralization / white spot lesion prevention (DIAGNOdent, enamel mineral content) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35) · 1 day to 6 months

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)

Oral cancer risk · People with and without more than 15 missing teeth · Missing teeth >15

Secondary prevention of caries · Children and adults (with or without carious lesions)

Patient satisfaction · Adults (> 18 years) with peri-implant mucositis, receiving active treatment

Enamel demineralization / white spot lesions (DIAGNOdent, photographic scoring) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35) · 1, 3 and 6 months (during treatment to debonding)

Decayed surfaces (DS) · Percentage of sites with CAL >=3 mm (tertiles); single study (Robert 2019); adjusted

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment (9 to 15 months)

Permanent-teeth caries experience (DMF/DMFT, mean score) · Institutionalized orphan children (roughly 3 to 18 years) · Overall (pooled)

Percussion pain at 7 days · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or… · 7 days

Change in gingival recession (REC) · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care · 3 months (change from baseline)

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · 3 to 6 months

Child oral health behaviour · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (AA+GG vs GA), Zhang 2006 removed, Sensitivity analysis (Zhang 2006 excluded)

Dental caries prevalence (any DMFT), dichotomous · Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts)

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months, Irreversible pulpitis

Quality of life · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment

Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · Gini index: no inequalities

Dental caries (ECC) · Preschool children under 6 years of age · First dental examination before age 6 years, Cohort studies; sensitivity analysis excluding studies 48 and 52

Oral cancer (OC) · Adults in case-control studies of oral cancer · Not specified, Overall (all missing-teeth measures pooled)

Dental caries in children · Children of mothers assessed for smoking status during pregnancy (early childhood dental caries) · Exposure during pregnancy; caries assessed in early childhood, Children's age: >3 years

Oral disease burden, slum vs non-slum urban comparison · Adult residents of slums and non-slum urban settings of LMICs · Cross-sectional, Slum vs non-slum urban / general population

Dental caries - genome-wide-significant loci · Japanese adults (present-study cohort: 30,859 dental caries cases / 14,666 controls) · Lifelong (germline genotype), Present-study GWAS (Japanese)

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible

Dental caries (early childhood caries) · Preschool children (<6 years) · Cohort studies

Caries arrestment at the tooth level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition) · 6 to 12 months, Overall (all comparators pooled)

Dental caries (early childhood caries) · Preschool children (<6 years) · Cohort studies

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Cariogenic microbiota counts (Streptococcus mutans, Lactobacillus spp.) · Narrative synthesis: significantly higher in CLP vs controls (Ahluwalia, Lucas, Hassani, Cheng, Sundell)

Overall success (composite of clinical and radiographic success) · Immature teeth, normal pulp/reversible pulpitis

Dental pain or sensitivity · Children and adults (with or without carious lesions) · 12 months, Children

Photographic white spot lesion score · Patients undergoing fixed orthodontic treatment · Before and after treatment

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Overall (all regions)

Secondary prevention of caries · Children and adults (with or without carious lesions)

Any adverse effect related to aPDT · Adults (> 18 years) with peri-implant mucositis, receiving active treatment

Early childhood caries (ECC) · Children with average age ≤3 years · Average age: ≤3 years

Dental caries experience (dmft), continuous · Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts)

Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

dmfs index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6…

Dental caries in children · Children of mothers assessed for smoking status during pregnancy (early childhood dental caries) · Exposure during pregnancy; caries assessed in early childhood, Children's age: <=3 years

Dental caries in children · Children of mothers assessed for smoking status during pregnancy (early childhood dental caries) · Exposure during pregnancy; caries assessed in early childhood, Sample size: >1000 and ≤3000

Difficulty in speech (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · 3 to 6 months

Mother self-reported oral health behaviours and attitudes · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…

Enamel remineralization extent and color change · Human enamel specimens around orthodontic brackets (in vitro) · pH cycling 21 days, Overall

Time to next/working arch wire · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)