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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

75,239 questions in 5,342 reviews

current versions
No studies 15,213 · 20.2%Ungraded 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Superelastic NiTi arch wire vs Conventional (stabilised) NiTi arch wire
Time to next/working arch wire · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Initial arch wires used in orthodontic treatment with fixed appliances (2024) · Cochrane
MD 0.40 [-0.10, 0.90]1 study · 88 participantsUngraded
Salivary F. nucleatum level vs Not specified
Salivary S. mutans level · Humans with salivary bacteria measured · Overall
Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024)
OR 6.03 [1.55, 23.45]1 studyUngraded
Slum / urban-disadvantaged setting vs Non-slum urban / general-urban / national population
Dental caries prevalence · Adult residents of slums and non-slum urban settings of LMICs · Cross-sectional
Systematic review of oral health in slums and non-slum urban settings of Low and Middle-Income Countries… (2024)
Prevalence of dental caries varied across age, gender and socioeconomic class, ranging from 13% (Nigeria) to 76% (Central India); prevalence >50% reported in India, Brazil, Malaysia and Rwanda; generally higher in…14 studiesUngraded
Teledentistry (index test): dental caries diagnosis from photographs taken with DSLR or smartphone cameras; store-and-forward vs Visual/clinical dental examination (reference standard)
Positive predictive value · Children and adults with primary or permanent dentition undergoing dental caries assessment · Cross-sectional diagnostic accuracy (index test vs reference standard, in-vivo), Overall (studies reporting PPV; narrative synthesis)
Teledentistry accuracy for caries diagnosis: a systematic review of in-vivo studies using extra-oral… (2024)
PPV 41.8% to 99%10 studiesUngraded
Intervention NR
Oral cancer (OC) · Sensitivity analysis: excluding Moraes et al. [34]
Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. (2024)
OR 2.63 [1.92, 3.62]7 studiesUngraded
Abdominal dermal fat graft vs Nasolabial flap
Adverse effects · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Interventions for managing oral submucous fibrosis (2024) · Cochrane
Kania 2022 reported 3/30 serious adverse effects (graft failure) requiring prolonged hospital stay in the abdominal dermal fat graft group; no GRADE rating.1 study · 30 participantsUngraded
Probiotics (any strain, dose, or presentation), minimum intake duration 0.2 months vs No treatment or placebo (control)
Salivary pH · Children and/or adolescents (<18 years) without background systemic disease · follow-up: mean 1.1 months, Overall (all presentations pooled)
Efficacy of Probiotic Consumption on Oral Outcomes in Children and/or Adolescents: A Meta-Analysis. (2024)
MD -0.12 [-0.72, 0.48]3 studies · 137 participantsVery low
Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics vs Matched placebo, partial or total chemo-mechanical debridement and analgesics
Adverse effects · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or… · 3 days
Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults (2024) · Cochrane
1 participant reported diarrhoea (placebo group); 1 participant reported fatigue and reduced energy postoperatively (antibiotic group). 61 participants (2 studies).2 studies · 61 participantsVery low
Facemask vs Untreated control (no treatment)
Self-esteem (Oral Aesthetic Subjective Impact Score, OASIS) · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · 3-year follow-up
Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane
MD -3.40 [-7.99, 1.19]1 study · 63 participantsUngraded
Intervention NR
Pathogenic bacteria / plaque composition around brackets (fewer pathogenic bacteria with flash-free vs APC; comparable plaque quantity)
Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed… (2024)
no estimate extracted1 studyUngraded
Occlusal splint vs No treatment or placebo (non-occlusal or transparent-foil placebo splint)
Frequency of joint noise · People with temporomandibular disorders (TMD) · Short term (mean 10 weeks), Myofascial pain TMD
Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane
RR 1.18 [0.63, 2.20]1 study · 60 participantsVery low
Pentoxifylline vs Placebo or no active treatment
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · 3 to 6 months
Interventions for managing oral submucous fibrosis (2024) · Cochrane
MD -0.15 [-5.04, 4.74]2 studies · 136 participantsVery low
Patient decision aids vs usual care
Congruence between informed values and choice ‐ all studies Based on the proportion of participants who made a decision that aligned with what was most important to them. Assessed soon after exposure to the decision aid. · adults considering treatment or screening decisions
Decision aids for people facing health treatment or screening decisions (2024) · Cochrane
RR 1.75 [1.44, 2.13]21 studies · 9377 participantsModerate
Patient decision aids vs usual care
Knowledge ‐ all studies Standardized on a scale from 0 (no knowledge) to 100 (perfect knowledge). Assessed soon after exposure to the decision aid. · adults considering treatment or screening decisions
Decision aids for people facing health treatment or screening decisions (2024) · Cochrane
no estimate extracted107 studies · 25492 participantsHigh
Patient decision aids vs usual care
Accurate risk perceptions ‐ all studies Based on the accuracy of perceived outcome probabilities according to the percentage of individuals whose judgments corresponded to the scientific evidence about the chances of an outcome for similar people.... · adults considering treatment or screening decisions
Decision aids for people facing health treatment or screening decisions (2024) · Cochrane
RR 1.94 [1.61, 2.34]25 studies · 7796 participantsHigh
Patient decision aids vs usual care
Decisional conflict: uninformed subscale ‐ all studies Standardized on a scale from 0 (informed) to 100 (uninformed). Assessed soon after exposure to the decision aid. · adults considering treatment or screening decisions
Decision aids for people facing health treatment or screening decisions (2024) · Cochrane
no estimate extracted58 studies · 12104 participantsHigh
Patient decision aids vs usual care
Decisional conflict: unclear about personal values subscale ‐ all studies Standardized on a scale from 0 (clear) to 100 (unclear). Assessed soon after exposure to the decision aid. · adults considering treatment or screening decisions
Decision aids for people facing health treatment or screening decisions (2024) · Cochrane
no estimate extracted55 studies · 11880 participantsHigh
Patient decision aids vs usual care
Participation in decision‐making: clinician‐controlled decision‐making ‐ all studies Based on the proportion of participants who indicated a passive role in decision‐making where the decision was primarily made by the clinician. Assessed soon afte... · adults considering treatment or screening decisions
Decision aids for people facing health treatment or screening decisions (2024) · Cochrane
RR 0.72 [0.59, 0.88]21 studies · 4348 participantsHigh
Patient decision aids vs usual care
Adverse events: decision regret ‐ all studies Standardized on a scale from 0 (no regret) to 100 (high regret). Assessed weeks to months after the decision is made. · adults considering treatment or screening decisions
Decision aids for people facing health treatment or screening decisions (2024) · Cochrane
no estimate extracted22 studies · 3707 participantsHigh
Surgery vs splint
Clinical improvement ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome
Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane
RR 2.1 [1.04, 4.24]3 studies · 210 participantsModerate
Surgery vs corticosteroid injection
Function ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome
Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane
no estimate extracted2 studies · 191 participantsModerate
Surgery vs corticosteroid injection
Pain (VAS) ‐ Long‐term improvement: > 3 monthsScale: 0 to 100, higher is worse · people with carpal tunnel syndrome
Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane
no estimate extracted1 study · 123 participantsModerate
Surgery vs corticosteroid injection
Health‐related quality of life ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome
Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane
no estimate extractedNRNo studies
Surgery vs corticosteroid injection
Adverse effects · people with carpal tunnel syndrome
Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane
RR 1.49 [0.25, 8.7]2 studies · 90 participantsVery low
Surgery vs corticosteroid injection
Need for surgery or secondary surgery during · people with carpal tunnel syndrome
Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane
RR 0.61 [0.25, 1.46]1 study · 163 participantsVery low
Surgery vs splint
Symptoms (Boston CTS questionnaire) ‐ Long‐term improvement: > 3 monthsScale: 1 to 5, higher is worse · people with carpal tunnel syndrome
Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane
no estimate extracted2 studies · 195 participantsModerate
Surgery vs splint
Function (Boston CTS questionnaire) ‐ Long‐term improvement: > 3 monthsScale: 1 to 5, higher is worse · people with carpal tunnel syndrome
Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane
no estimate extracted2 studies · 195 participantsModerate
Surgery vs splint
Pain ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome
Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane
no estimate extractedNRNo studies
Surgery vs splint
Health‐related quality of life (EQ‐5D) ‐ Long‐term improvement: > 3 months Scale: 0 to 1, higher is better · people with carpal tunnel syndrome
Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane
no estimate extracted1 study · 167 participantsLow
Surgery vs splint
Adverse effects · people with carpal tunnel syndrome
Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane
RR 2.11 [0.37, 12.12]2 studies · 210 participantsVery low
Surgery vs splint
Need for surgery or secondary surgery during · people with carpal tunnel syndrome
Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane
RR 0.03 [0, 0.21]2 studies · 176 participantsModerate
Surgery vs corticosteroid injection
Clinical improvement ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome
Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane
RR 1.23 [0.73, 2.06]3 studies · 187 participantsVery low
Surgery vs corticosteroid injection
Symptoms ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome
Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane
no estimate extracted2 studies · 118 participantsVery low
Intravenous immunoglobulin vs placebo
Significant improvement in disability within 6 weeks · people with CIDP
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane
RR 2.4 [1.72, 3.36]5 studies · 269 participantsHigh
Intravenous immunoglobulin vs prednisolone
Change in mean disability score on Rankin scale · patients with CIDP
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane
no estimate extracted1 study · 24 participantsModerate
Intravenous immunoglobulin vs prednisolone
Change in mean disability score at 24 weeks or later · patients with CIDP
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane
no estimate extractedNRNo studies
Intravenous immunoglobulin vs prednisolone
Serious adverse events · patients with CIDP
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane
RR 0.45 [0.04, 4.69]1 study · 57 participantsModerate
Intravenous immunoglobulin vs intravenous methylprednisolone
Significant improvement in disability within 6 weeks · people with CIDP
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane
RR 1.46 [0.4, 5.38]1 study · 45 participantsModerate
Intravenous immunoglobulin vs intravenous methylprednisolone
Change in mean disability score on Rankin scale · people with CIDP
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane
no estimate extracted1 study · 43 participantsModerate
Intravenous immunoglobulin vs intravenous methylprednisolone
Change in mean disability score at 24 weeks or later · people with CIDP
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane
no estimate extracted1 study · 45 participantsModerate
Intravenous immunoglobulin vs intravenous methylprednisolone
Serious adverse events · people with CIDP
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane
RR 4.4 [0.22, 86.78]1 study · 45 participantsModerate
Intravenous immunoglobulin vs placebo
Change in mean disability score on Rankin scale · people with CIDP
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane
no estimate extracted3 studies · 90 participantsHigh
Intravenous immunoglobulin vs placebo
Change in mean disability score at 24 weeks or later · people with CIDP
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane
no estimate extracted1 study · 117 participantsModerate
Intravenous immunoglobulin vs placebo
Serious adverse events · people with CIDP
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane
RR 0.82 [0.36, 1.87]3 studies · 315 participantsModerate
Intravenous immunoglobulin vs plasma exchange
Significant improvement in disability within 6 weeks · people with CIDP
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane
no estimate extractedNRNo studies
Intravenous immunoglobulin vs plasma exchange
Change in mean disability score on Rankin scale · people with CIDP
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane
no estimate extractedNRNo studies
Intravenous immunoglobulin vs plasma exchange
Change in mean disability score at 24 weeks or later · people with CIDP
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane
no estimate extractedNRNo studies
Intravenous immunoglobulin vs plasma exchange
Serious adverse events · people with CIDP
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane
no estimate extracted1 study · 20 participantsUngraded
Intravenous immunoglobulin vs prednisolone
Significant improvement in disability within 6 weeks · patients with CIDP
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane
RR 0.91 [0.5, 1.68]1 study · 29 participantsModerate
Smoking cessation counselling vs no smoking cessation counselling, grouped by intensity of intervention
Quit at longest · individuals who smoke cigarettes and are admitted to a hospital for medical or surgical care
Interventions for smoking cessation in hospitalised patients (2024) · Cochrane
RR 1.52 [0.8, 2.89]2 studies · 1417 participantsVery low