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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
75,239 questions in 5,342 reviews
current versionsNo studies 15,213 · 20.2%Ungraded 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Superelastic NiTi arch wire vs Conventional (stabilised) NiTi arch wire Time to next/working arch wire · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch) Initial arch wires used in orthodontic treatment with fixed appliances (2024) · Cochrane | MD 0.40 [-0.10, 0.90] | 1 study · 88 participants | Ungraded |
Salivary F. nucleatum level vs Not specified Salivary S. mutans level · Humans with salivary bacteria measured · Overall Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024) | OR 6.03 [1.55, 23.45] | 1 study | Ungraded |
Slum / urban-disadvantaged setting vs Non-slum urban / general-urban / national population Dental caries prevalence · Adult residents of slums and non-slum urban settings of LMICs · Cross-sectional Systematic review of oral health in slums and non-slum urban settings of Low and Middle-Income Countries… (2024) | Prevalence of dental caries varied across age, gender and socioeconomic class, ranging from 13% (Nigeria) to 76% (Central India); prevalence >50% reported in India, Brazil, Malaysia and Rwanda; generally higher in… | 14 studies | Ungraded |
Teledentistry (index test): dental caries diagnosis from photographs taken with DSLR or smartphone cameras; store-and-forward vs Visual/clinical dental examination (reference standard) Positive predictive value · Children and adults with primary or permanent dentition undergoing dental caries assessment · Cross-sectional diagnostic accuracy (index test vs reference standard, in-vivo), Overall (studies reporting PPV; narrative synthesis) Teledentistry accuracy for caries diagnosis: a systematic review of in-vivo studies using extra-oral… (2024) | PPV 41.8% to 99% | 10 studies | Ungraded |
Intervention NR Oral cancer (OC) · Sensitivity analysis: excluding Moraes et al. [34] Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. (2024) | OR 2.63 [1.92, 3.62] | 7 studies | Ungraded |
Abdominal dermal fat graft vs Nasolabial flap Adverse effects · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) Interventions for managing oral submucous fibrosis (2024) · Cochrane | Kania 2022 reported 3/30 serious adverse effects (graft failure) requiring prolonged hospital stay in the abdominal dermal fat graft group; no GRADE rating. | 1 study · 30 participants | Ungraded |
Probiotics (any strain, dose, or presentation), minimum intake duration 0.2 months vs No treatment or placebo (control) Salivary pH · Children and/or adolescents (<18 years) without background systemic disease · follow-up: mean 1.1 months, Overall (all presentations pooled) Efficacy of Probiotic Consumption on Oral Outcomes in Children and/or Adolescents: A Meta-Analysis. (2024) | MD -0.12 [-0.72, 0.48] | 3 studies · 137 participants | Very low |
Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics vs Matched placebo, partial or total chemo-mechanical debridement and analgesics Adverse effects · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or… · 3 days Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults (2024) · Cochrane | 1 participant reported diarrhoea (placebo group); 1 participant reported fatigue and reduced energy postoperatively (antibiotic group). 61 participants (2 studies). | 2 studies · 61 participants | Very low |
Facemask vs Untreated control (no treatment) Self-esteem (Oral Aesthetic Subjective Impact Score, OASIS) · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · 3-year follow-up Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane | MD -3.40 [-7.99, 1.19] | 1 study · 63 participants | Ungraded |
Intervention NR Pathogenic bacteria / plaque composition around brackets (fewer pathogenic bacteria with flash-free vs APC; comparable plaque quantity) Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed… (2024) | no estimate extracted | 1 study | Ungraded |
Occlusal splint vs No treatment or placebo (non-occlusal or transparent-foil placebo splint) Frequency of joint noise · People with temporomandibular disorders (TMD) · Short term (mean 10 weeks), Myofascial pain TMD Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane | RR 1.18 [0.63, 2.20] | 1 study · 60 participants | Very low |
Pentoxifylline vs Placebo or no active treatment Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · 3 to 6 months Interventions for managing oral submucous fibrosis (2024) · Cochrane | MD -0.15 [-5.04, 4.74] | 2 studies · 136 participants | Very low |
Patient decision aids vs usual care Congruence between informed values and choice ‐ all studies Based on the proportion of participants who made a decision that aligned with what was most important to them. Assessed soon after exposure to the decision aid. · adults considering treatment or screening decisions Decision aids for people facing health treatment or screening decisions (2024) · Cochrane | RR 1.75 [1.44, 2.13] | 21 studies · 9377 participants | Moderate |
Patient decision aids vs usual care Knowledge ‐ all studies Standardized on a scale from 0 (no knowledge) to 100 (perfect knowledge). Assessed soon after exposure to the decision aid. · adults considering treatment or screening decisions Decision aids for people facing health treatment or screening decisions (2024) · Cochrane | no estimate extracted | 107 studies · 25492 participants | High |
Patient decision aids vs usual care Accurate risk perceptions ‐ all studies Based on the accuracy of perceived outcome probabilities according to the percentage of individuals whose judgments corresponded to the scientific evidence about the chances of an outcome for similar people.... · adults considering treatment or screening decisions Decision aids for people facing health treatment or screening decisions (2024) · Cochrane | RR 1.94 [1.61, 2.34] | 25 studies · 7796 participants | High |
Patient decision aids vs usual care Decisional conflict: uninformed subscale ‐ all studies Standardized on a scale from 0 (informed) to 100 (uninformed). Assessed soon after exposure to the decision aid. · adults considering treatment or screening decisions Decision aids for people facing health treatment or screening decisions (2024) · Cochrane | no estimate extracted | 58 studies · 12104 participants | High |
Patient decision aids vs usual care Decisional conflict: unclear about personal values subscale ‐ all studies Standardized on a scale from 0 (clear) to 100 (unclear). Assessed soon after exposure to the decision aid. · adults considering treatment or screening decisions Decision aids for people facing health treatment or screening decisions (2024) · Cochrane | no estimate extracted | 55 studies · 11880 participants | High |
Patient decision aids vs usual care Participation in decision‐making: clinician‐controlled decision‐making ‐ all studies Based on the proportion of participants who indicated a passive role in decision‐making where the decision was primarily made by the clinician. Assessed soon afte... · adults considering treatment or screening decisions Decision aids for people facing health treatment or screening decisions (2024) · Cochrane | RR 0.72 [0.59, 0.88] | 21 studies · 4348 participants | High |
Patient decision aids vs usual care Adverse events: decision regret ‐ all studies Standardized on a scale from 0 (no regret) to 100 (high regret). Assessed weeks to months after the decision is made. · adults considering treatment or screening decisions Decision aids for people facing health treatment or screening decisions (2024) · Cochrane | no estimate extracted | 22 studies · 3707 participants | High |
Surgery vs splint Clinical improvement ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane | RR 2.1 [1.04, 4.24] | 3 studies · 210 participants | Moderate |
Surgery vs corticosteroid injection Function ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane | no estimate extracted | 2 studies · 191 participants | Moderate |
Surgery vs corticosteroid injection Pain (VAS) ‐ Long‐term improvement: > 3 monthsScale: 0 to 100, higher is worse · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane | no estimate extracted | 1 study · 123 participants | Moderate |
Surgery vs corticosteroid injection Health‐related quality of life ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane | no estimate extracted | NR | No studies |
Surgery vs corticosteroid injection Adverse effects · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane | RR 1.49 [0.25, 8.7] | 2 studies · 90 participants | Very low |
Surgery vs corticosteroid injection Need for surgery or secondary surgery during · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane | RR 0.61 [0.25, 1.46] | 1 study · 163 participants | Very low |
Surgery vs splint Symptoms (Boston CTS questionnaire) ‐ Long‐term improvement: > 3 monthsScale: 1 to 5, higher is worse · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane | no estimate extracted | 2 studies · 195 participants | Moderate |
Surgery vs splint Function (Boston CTS questionnaire) ‐ Long‐term improvement: > 3 monthsScale: 1 to 5, higher is worse · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane | no estimate extracted | 2 studies · 195 participants | Moderate |
Surgery vs splint Pain ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane | no estimate extracted | NR | No studies |
Surgery vs splint Health‐related quality of life (EQ‐5D) ‐ Long‐term improvement: > 3 months Scale: 0 to 1, higher is better · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane | no estimate extracted | 1 study · 167 participants | Low |
Surgery vs splint Adverse effects · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane | RR 2.11 [0.37, 12.12] | 2 studies · 210 participants | Very low |
Surgery vs splint Need for surgery or secondary surgery during · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane | RR 0.03 [0, 0.21] | 2 studies · 176 participants | Moderate |
Surgery vs corticosteroid injection Clinical improvement ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane | RR 1.23 [0.73, 2.06] | 3 studies · 187 participants | Very low |
Surgery vs corticosteroid injection Symptoms ‐ Long‐term improvement: > 3 months · people with carpal tunnel syndrome Surgical versus non‐surgical treatment for carpal tunnel syndrome (2024) · Cochrane | no estimate extracted | 2 studies · 118 participants | Very low |
Intravenous immunoglobulin vs placebo Significant improvement in disability within 6 weeks · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane | RR 2.4 [1.72, 3.36] | 5 studies · 269 participants | High |
Intravenous immunoglobulin vs prednisolone Change in mean disability score on Rankin scale · patients with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane | no estimate extracted | 1 study · 24 participants | Moderate |
Intravenous immunoglobulin vs prednisolone Change in mean disability score at 24 weeks or later · patients with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane | no estimate extracted | NR | No studies |
Intravenous immunoglobulin vs prednisolone Serious adverse events · patients with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane | RR 0.45 [0.04, 4.69] | 1 study · 57 participants | Moderate |
Intravenous immunoglobulin vs intravenous methylprednisolone Significant improvement in disability within 6 weeks · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane | RR 1.46 [0.4, 5.38] | 1 study · 45 participants | Moderate |
Intravenous immunoglobulin vs intravenous methylprednisolone Change in mean disability score on Rankin scale · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane | no estimate extracted | 1 study · 43 participants | Moderate |
Intravenous immunoglobulin vs intravenous methylprednisolone Change in mean disability score at 24 weeks or later · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane | no estimate extracted | 1 study · 45 participants | Moderate |
Intravenous immunoglobulin vs intravenous methylprednisolone Serious adverse events · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane | RR 4.4 [0.22, 86.78] | 1 study · 45 participants | Moderate |
Intravenous immunoglobulin vs placebo Change in mean disability score on Rankin scale · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane | no estimate extracted | 3 studies · 90 participants | High |
Intravenous immunoglobulin vs placebo Change in mean disability score at 24 weeks or later · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane | no estimate extracted | 1 study · 117 participants | Moderate |
Intravenous immunoglobulin vs placebo Serious adverse events · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane | RR 0.82 [0.36, 1.87] | 3 studies · 315 participants | Moderate |
Intravenous immunoglobulin vs plasma exchange Significant improvement in disability within 6 weeks · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane | no estimate extracted | NR | No studies |
Intravenous immunoglobulin vs plasma exchange Change in mean disability score on Rankin scale · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane | no estimate extracted | NR | No studies |
Intravenous immunoglobulin vs plasma exchange Change in mean disability score at 24 weeks or later · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane | no estimate extracted | NR | No studies |
Intravenous immunoglobulin vs plasma exchange Serious adverse events · people with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane | no estimate extracted | 1 study · 20 participants | Ungraded |
Intravenous immunoglobulin vs prednisolone Significant improvement in disability within 6 weeks · patients with CIDP Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy (2024) · Cochrane | RR 0.91 [0.5, 1.68] | 1 study · 29 participants | Moderate |
Smoking cessation counselling vs no smoking cessation counselling, grouped by intensity of intervention Quit at longest · individuals who smoke cigarettes and are admitted to a hospital for medical or surgical care Interventions for smoking cessation in hospitalised patients (2024) · Cochrane | RR 1.52 [0.8, 2.89] | 2 studies · 1417 participants | Very low |