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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

5,762 questions in 263 reviews · Dental caries

current versions
No studies 321 · 5.6%Ungraded 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs Standard care
Mother plaque (sub- and supragingival calculus) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…
Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane
RR 0.92 [0.62, 1.37]1 study · 133 participantsUngraded
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)
Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · Region: North America
A systematic review and meta-analysis on early-childhood-caries global data. (2024)
MEAN 3.89 [1.62, 6.16]7 studiesUngraded
Silver diamine fluoride (SDF) vs Placebo or no treatment
Primary caries prevention · Children and adults (with or without carious lesions) · 24 to 36 months, Permanent dentition (root)
Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane
MD -0.79 [-1.40, -0.17]3 studies · 439 participantsModerate
Cdx-2(rs11568820) A allele / genotype vs G allele / reference genotype
Dental caries · Children (<18 years) with vs without dental caries · Not meta-analyzed (single study)
Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024)
Cdx-2(rs11568820) was reported by only one study (Qin 2019; 303 caries, 245 caries-free) and was therefore not subjected to meta-analysis (Results 'Meta-analysis'; Table 6).1 study · 548 participantsUngraded
Fluoride toothpaste less than 1000 ppm (lower concentration) vs Fluoride toothpaste 1000 ppm or more (higher concentration)
Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)
Topical fluoride as a cause of dental fluorosis in children (2024) · Cochrane
OR 0.79 [0.62, 1.02]3 studies · 2037 participantsVery low
T allele vs C allele
Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C)
Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024)
OR 1.01 [0.83, 1.21]6 studies · 1986 participantsUngraded
Intervention NR
Dental caries in children · Children's age subgroup: 2 to 4 years
Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic… (2024)
OR 1.20 [1.04, 1.36]4 studiesUngraded
Silver diamine fluoride (SDF) vs Restoration (restorative treatment)
Caries arrest · Children and adults (with or without carious lesions) · 12 months, Primary dentition (coronal)
Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane
OR 0.03 [0.01, 0.10]1 study · 98 participantsVery low
Overweight vs Normal weight (eutrophic)
Dental caries experience (dmft), continuous · Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts)
Overweight/obesity and dental caries in Brazilian children and adolescents: a systematic review and… (2024)
MD 0.31 [-0.10, 0.73]2 studies · 734 participantsVery low
Silver diamine fluoride (SDF) vs Placebo, control, and/or other interventions
Caries arrestment at the individual level · Children and adults without systemic diseases affecting dental health · 3 weeks to 12 months
The role of silver diamine fluoride as dental caries preventive and arresting agent: a systematic review and… (2024)
OR 3.86 [0.34, 43.96]5 studies · 720 participantsLow
Maternal smoking during pregnancy vs No maternal smoking during pregnancy
Dental caries in children · Children of mothers assessed for smoking status during pregnancy (early childhood dental caries) · Exposure during pregnancy; caries assessed in early childhood, Study region: Asia
Maternal smoking during pregnancy and early childhood dental caries in children: a systematic review and… (2024)
OR 1.71 [1.40, 2.10]5 studiesUngraded
TT+TG genotypes vs GG genotype
Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TG vs GG)
Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024)
OR 1.09 [0.76, 1.58]3 studies · 796 participantsUngraded
T allele vs C allele
Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Asian ethnicity
Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024)
OR 0.98 [0.65, 1.50]NRUngraded
Intervention NR
Change in Lactobacillus spp. in dental plaque · Single study (Ly et al. 2008), xylitol or maltitol, not pooled
Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis. (2024)
Narrative (no effect size) No significant change in Lactobacillus spp. after xylitol or maltitol consumption1 studyUngraded
Silver diamine fluoride (SDF) vs Glass ionomer cement (GIC) plus fluoride varnish
Adverse effects · Children and adults (with or without carious lesions) · 6 months
Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane
Parents were asked if any harm was noticed due to the use of SDF, but the results were not reported in the study report; we could not determine whether there were any associated harms with either treatment (Mendiratta…1 studyUngraded
ACP light-cure adhesive vs Control Transbond XT adhesive
Enamel demineralization score · Patients undergoing fixed orthodontic treatment · 6 months after bonding
Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed… (2024)
At T2, the control group had an average score of 4.32 (±2.32), while the ACP group continued to exhibit a lower average score of 3.41 (±1.11) (p-value of 0.000).1 study · 26 participantsUngraded
Periodontitis vs No periodontitis
High salivary P. gingivalis (over 10^4 CFU/ml) · Adults · Overall
Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024)
OR 3.38 [1.46, 7.83]2 studiesUngraded
Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material
Primary caries prevention · Children and adults (with or without carious lesions) · Primary and permanent dentition
Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane
No studies reported this outcome0 studiesNo studies
Second molar at Demirjian stage E at extraction vs Second molar at Demirjian stage F-H at extraction
Spontaneous space closure · Children and adolescents after extraction of a maxillary permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Maxilla
Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024)
OR 4.78 [1.56, 14.66]3 studies · 252 participantsLow
Er:YAG laser irradiation vs Untreated / high-speed-handpiece control enamel
Enamel resistance to demineralization (microhardness / lesion depth) · Human enamel adjacent to restorations or in pits and fissures (in situ / ex vivo)
Clinical and ex-vivo effect of LASERs on prevention of early-enamel caries: systematic review & meta-analyses. (2024)
Narrative only (not meta-analyzed). Colucci: Er:YAG laser feasible for controlling caries progression adjacent to restorations but not able to prevent caries formation (optimum 2 Hz). Correa-Afonso: Er:YAG did not…2 studiesUngraded
Oral health education/promotion (oral hygiene advice plus diet and feeding practice advice) combined with clinical treatment for mother's dentition (basic restorative and preventive; 1 trial included CHX varnish application) vs Standard care
dmft index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6… · Children assessed at 18 months
Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane
The mean dmft index score was 0.52 (standard care) versus 0 (advice + treatment group); relative effect not estimable; 50 participants (1 study); very low-certainty evidence.1 study · 50 participantsVery low
Silver diamine fluoride (SDF) vs Silver nitrate plus fluoride varnish
Adverse effects · Children and adults (with or without carious lesions) · 18 months, Children
Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane
Gao 2019 noted that "arrested lesions were stained black" (reported with no associated data). No other adverse effects observed, and no reports from parents of systemic disease.1 study · 1070 participantsVery low
Prenatal vitamin D deficiency (PVDD) vs Normal or sufficient prenatal vitamin D level
Dental caries prevalence · Children aged 2 to 8 years · Maternal pregnancy to child age 2 to 8 years, Children of mothers with sufficient prenatal vitamin D
Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic… (2024)
Proportion 0.25NRUngraded
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)
Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · GNI $10000-$19999
A systematic review and meta-analysis on early-childhood-caries global data. (2024)
MEAN 4.04 [2.39, 5.68]9 studiesUngraded
Oral cancer patients (cases) vs Healthy controls
DMFT index in OC cases vs controls · Adults in case-control studies (oral cancer patients vs healthy controls) · Not specified, DMFT (decayed, missing, filled teeth)
Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. (2024)
SMD 0.65 [0.12, 1.18]2 studiesUngraded
Intervention NR
Overall success (composite of clinical and radiographic success) · Mature teeth, partial pulpotomy, irreversible pulpitis
Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis… (2024)
Proportion 0.808 [0.723, 0.881]5 studiesUngraded
Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride)
Biofilm morphological changes · Streptococcus mutans (in vitro cultures and biofilms)
Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024)
Cranberry treatment disrupted biofilm integrity with agglutination/cell degradation at higher concentrations (Singhal), reduced polymicrobial biomass 38% at 96 h (Philip 2019), produced defective accumulation and…4 studiesUngraded
Intervention NR
Spontaneous space closure · Maxilla: M2 Demirjian A-D vs G-H
Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024)
OR >100.001 studyUngraded
T allele vs C allele
Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Mixed dentition
Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024)
OR 0.80 [0.55, 1.15]NRUngraded
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)
Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · Life expectancy: 71-75 years
A systematic review and meta-analysis on early-childhood-caries global data. (2024)
MEAN 5.18NRUngraded
Cesarean section delivery vs Vaginal delivery
Early childhood caries (ECC) · Children aged <6 years · Study location: Europe
RETRACTED: The association between mode of childbirth delivery and early childhood caries: A comprehensive… (2024)
OR 1.48 [0.83, 2.63]5 studiesUngraded
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)
Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Gini index: no inequality
A systematic review and meta-analysis on early-childhood-caries global data. (2024)
Prevalence 62NRUngraded
Cleft lip and palate vs No cleft lip and palate
Lactobacillus spp. mean levels/counts · Children and adolescents aged 0 to 18 years with nonsyndromic cleft lip and palate
Characterization of the oral microbiota and the relationship of the oral microbiota with the dental and… (2024)
MD 1.40 [1.33, 1.47]2 studies · 152 participantsUngraded
Overweight vs Normal weight (eutrophic)
Dental caries experience (DMFT), continuous · Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts)
Overweight/obesity and dental caries in Brazilian children and adolescents: a systematic review and… (2024)
MD -0.06 [-1.03, 0.91]2 studies · 446 participantsVery low
TT+TC genotypes vs CC genotype
Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Real-time quantitative PCR genotyping
Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024)
OR 0.87 [0.47, 1.61]NRUngraded
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)
Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Region: Africa
A systematic review and meta-analysis on early-childhood-caries global data. (2024)
Prevalence 42 [32, 53]3 studiesUngraded
Intervention NR
Overall success (composite of clinical and radiographic success) · Full pulpotomy, irreversible pulpitis
Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis… (2024)
Proportion 0.837 [0.741, 0.916]12 studiesUngraded
Started toothbrushing with fluoride toothpaste at or before 24 months (earlier start) vs Started after 24 months (later start)
Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)
Topical fluoride as a cause of dental fluorosis in children (2024) · Cochrane
RR 0.83 [0.61, 1.13]1 study · 3939 participantsVery low
Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs Standard care
dmft index score · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…
Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane
dmft was listed in the SoF table but not assessed (not reported for this comparison).0 studiesNo studies
Oral cancer patients (cases) vs Healthy controls
Mean number of missing teeth in OC cases vs controls · Adults in case-control studies (oral cancer patients vs healthy controls) · Not specified, Missing teeth (mean count)
Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. (2024)
SMD 0.59 [-0.04, 1.22]3 studiesUngraded
Intervention NR
Decayed, missing, filled surfaces (DMFS) · Percentage of sites with CAL >=3 mm (tertiles); single study (Robert 2019); adjusted
Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024)
OR 1.03 [1.00, 1.05]1 studyUngraded
Intervention NR
Serum vitamin D (25(OH)D): ECC vs caries-free · Cross-sectional studies (Fig 3)
The Association Between Vitamin D and Early Childhood Caries: A Systematic Review and Meta-Analysis. (2024)
Mean difference -6.10 [-8.02, -4.19]3 studiesUngraded
Presence of oral Candida albicans vs Absence of oral Candida albicans
Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Region: Asia
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A… (2024)
OR 3.62 [2.53, 5.20]12 studies · 2347 participantsUngraded
Probiotics (any strain, dose, or presentation), minimum intake duration 0.2 months vs No treatment or placebo (control)
Lactobacillus count (CFU/mL) · Children and/or adolescents (<18 years) without background systemic disease · follow-up: mean 5.2 months, Overall (all presentations pooled)
Efficacy of Probiotic Consumption on Oral Outcomes in Children and/or Adolescents: A Meta-Analysis. (2024)
MD -0.78 [-1.65, 0.09]6 studies · 1143 participantsVery low
Maternal smoking during pregnancy vs No maternal smoking during pregnancy
Dental caries · Children · Study region: Australia
Maternal smoking during pregnancy and early childhood dental caries in children: a systematic review and… (2024)
OR 1.68 [1.35, 2.10]1 studyUngraded
Serum 25(OH)D 50–75 nmol/l vs Serum 25(OH)D ≥ 75 nmol/l
Early childhood caries (ECC) · Preschool children ≤6 years
The Association Between Vitamin D and Early Childhood Caries: A Systematic Review and Meta-Analysis. (2024)
OR 1.42 [1.26, 1.60]6 studies · 5746 participantsUngraded
CO2 laser combined with fluoride vs Fluoride alone
Enamel demineralization / mineral loss · Human enamel specimens under cariogenic challenge (in situ / ex vivo)
Clinical and ex-vivo effect of LASERs on prevention of early-enamel caries: systematic review & meta-analyses. (2024)
Narrative only (secondary question: laser-fluoride synergy). Takate: combined low-power CO2 laser plus 1.23% APF gave greater inhibition of mineral loss than either alone (APF after laser gave maximum inhibition).…2 studiesUngraded
M2 Demirjian stages F-G vs M2 Demirjian stages E-D
Spontaneous space closure · Children and adolescents with maxillary permanent first molar extraction · Follow-up to complete eruption of the permanent second molar, Maxilla
Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024)
OR >100.00 [0.01, >100.00]3 studiesUngraded
Highest BMI category (overweight/obese) vs Lowest BMI category (normal weight/underweight)
Dental caries / early childhood caries (ECC) · Children (approx. 4-18 years) · Sample size: >900
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… (2024)
OR 1.59 [1.25, 2.02]8 studiesUngraded
Remineralizing orthodontic adhesives vs Control orthodontic adhesives
Ion release · Human teeth with early enamel lesions surrounding orthodontic brackets · 14 days to 6 months
Remineralization and anti-demineralization effect of orthodontic adhesives on enamel surrounding orthodontic… (2024)
no estimate extracted8 studiesUngraded