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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
5,762 questions in 263 reviews · Dental caries
current versionsNo studies 321 · 5.6%Ungraded 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs Standard care Mother plaque (sub- and supragingival calculus) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane | RR 0.92 [0.62, 1.37] | 1 study · 133 participants | Ungraded |
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence) Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · Region: North America A systematic review and meta-analysis on early-childhood-caries global data. (2024) | MEAN 3.89 [1.62, 6.16] | 7 studies | Ungraded |
Silver diamine fluoride (SDF) vs Placebo or no treatment Primary caries prevention · Children and adults (with or without carious lesions) · 24 to 36 months, Permanent dentition (root) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | MD -0.79 [-1.40, -0.17] | 3 studies · 439 participants | Moderate |
Cdx-2(rs11568820) A allele / genotype vs G allele / reference genotype Dental caries · Children (<18 years) with vs without dental caries · Not meta-analyzed (single study) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | Cdx-2(rs11568820) was reported by only one study (Qin 2019; 303 caries, 245 caries-free) and was therefore not subjected to meta-analysis (Results 'Meta-analysis'; Table 6). | 1 study · 548 participants | Ungraded |
Fluoride toothpaste less than 1000 ppm (lower concentration) vs Fluoride toothpaste 1000 ppm or more (higher concentration) Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years) Topical fluoride as a cause of dental fluorosis in children (2024) · Cochrane | OR 0.79 [0.62, 1.02] | 3 studies · 2037 participants | Very low |
T allele vs C allele Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.01 [0.83, 1.21] | 6 studies · 1986 participants | Ungraded |
Intervention NR Dental caries in children · Children's age subgroup: 2 to 4 years Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic… (2024) | OR 1.20 [1.04, 1.36] | 4 studies | Ungraded |
Silver diamine fluoride (SDF) vs Restoration (restorative treatment) Caries arrest · Children and adults (with or without carious lesions) · 12 months, Primary dentition (coronal) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | OR 0.03 [0.01, 0.10] | 1 study · 98 participants | Very low |
Overweight vs Normal weight (eutrophic) Dental caries experience (dmft), continuous · Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts) Overweight/obesity and dental caries in Brazilian children and adolescents: a systematic review and… (2024) | MD 0.31 [-0.10, 0.73] | 2 studies · 734 participants | Very low |
Silver diamine fluoride (SDF) vs Placebo, control, and/or other interventions Caries arrestment at the individual level · Children and adults without systemic diseases affecting dental health · 3 weeks to 12 months The role of silver diamine fluoride as dental caries preventive and arresting agent: a systematic review and… (2024) | OR 3.86 [0.34, 43.96] | 5 studies · 720 participants | Low |
Maternal smoking during pregnancy vs No maternal smoking during pregnancy Dental caries in children · Children of mothers assessed for smoking status during pregnancy (early childhood dental caries) · Exposure during pregnancy; caries assessed in early childhood, Study region: Asia Maternal smoking during pregnancy and early childhood dental caries in children: a systematic review and… (2024) | OR 1.71 [1.40, 2.10] | 5 studies | Ungraded |
TT+TG genotypes vs GG genotype Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TG vs GG) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.09 [0.76, 1.58] | 3 studies · 796 participants | Ungraded |
T allele vs C allele Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Asian ethnicity Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.98 [0.65, 1.50] | NR | Ungraded |
Intervention NR Change in Lactobacillus spp. in dental plaque · Single study (Ly et al. 2008), xylitol or maltitol, not pooled Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis. (2024) | Narrative (no effect size) No significant change in Lactobacillus spp. after xylitol or maltitol consumption | 1 study | Ungraded |
Silver diamine fluoride (SDF) vs Glass ionomer cement (GIC) plus fluoride varnish Adverse effects · Children and adults (with or without carious lesions) · 6 months Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | Parents were asked if any harm was noticed due to the use of SDF, but the results were not reported in the study report; we could not determine whether there were any associated harms with either treatment (Mendiratta… | 1 study | Ungraded |
ACP light-cure adhesive vs Control Transbond XT adhesive Enamel demineralization score · Patients undergoing fixed orthodontic treatment · 6 months after bonding Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed… (2024) | At T2, the control group had an average score of 4.32 (±2.32), while the ACP group continued to exhibit a lower average score of 3.41 (±1.11) (p-value of 0.000). | 1 study · 26 participants | Ungraded |
Periodontitis vs No periodontitis High salivary P. gingivalis (over 10^4 CFU/ml) · Adults · Overall Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024) | OR 3.38 [1.46, 7.83] | 2 studies | Ungraded |
Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material Primary caries prevention · Children and adults (with or without carious lesions) · Primary and permanent dentition Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported this outcome | 0 studies | No studies |
Second molar at Demirjian stage E at extraction vs Second molar at Demirjian stage F-H at extraction Spontaneous space closure · Children and adolescents after extraction of a maxillary permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Maxilla Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 4.78 [1.56, 14.66] | 3 studies · 252 participants | Low |
Er:YAG laser irradiation vs Untreated / high-speed-handpiece control enamel Enamel resistance to demineralization (microhardness / lesion depth) · Human enamel adjacent to restorations or in pits and fissures (in situ / ex vivo) Clinical and ex-vivo effect of LASERs on prevention of early-enamel caries: systematic review & meta-analyses. (2024) | Narrative only (not meta-analyzed). Colucci: Er:YAG laser feasible for controlling caries progression adjacent to restorations but not able to prevent caries formation (optimum 2 Hz). Correa-Afonso: Er:YAG did not… | 2 studies | Ungraded |
Oral health education/promotion (oral hygiene advice plus diet and feeding practice advice) combined with clinical treatment for mother's dentition (basic restorative and preventive; 1 trial included CHX varnish application) vs Standard care dmft index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6… · Children assessed at 18 months Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane | The mean dmft index score was 0.52 (standard care) versus 0 (advice + treatment group); relative effect not estimable; 50 participants (1 study); very low-certainty evidence. | 1 study · 50 participants | Very low |
Silver diamine fluoride (SDF) vs Silver nitrate plus fluoride varnish Adverse effects · Children and adults (with or without carious lesions) · 18 months, Children Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | Gao 2019 noted that "arrested lesions were stained black" (reported with no associated data). No other adverse effects observed, and no reports from parents of systemic disease. | 1 study · 1070 participants | Very low |
Prenatal vitamin D deficiency (PVDD) vs Normal or sufficient prenatal vitamin D level Dental caries prevalence · Children aged 2 to 8 years · Maternal pregnancy to child age 2 to 8 years, Children of mothers with sufficient prenatal vitamin D Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic… (2024) | Proportion 0.25 | NR | Ungraded |
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence) Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · GNI $10000-$19999 A systematic review and meta-analysis on early-childhood-caries global data. (2024) | MEAN 4.04 [2.39, 5.68] | 9 studies | Ungraded |
Oral cancer patients (cases) vs Healthy controls DMFT index in OC cases vs controls · Adults in case-control studies (oral cancer patients vs healthy controls) · Not specified, DMFT (decayed, missing, filled teeth) Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. (2024) | SMD 0.65 [0.12, 1.18] | 2 studies | Ungraded |
Intervention NR Overall success (composite of clinical and radiographic success) · Mature teeth, partial pulpotomy, irreversible pulpitis Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis… (2024) | Proportion 0.808 [0.723, 0.881] | 5 studies | Ungraded |
Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride) Biofilm morphological changes · Streptococcus mutans (in vitro cultures and biofilms) Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | Cranberry treatment disrupted biofilm integrity with agglutination/cell degradation at higher concentrations (Singhal), reduced polymicrobial biomass 38% at 96 h (Philip 2019), produced defective accumulation and… | 4 studies | Ungraded |
Intervention NR Spontaneous space closure · Maxilla: M2 Demirjian A-D vs G-H Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR >100.00 | 1 study | Ungraded |
T allele vs C allele Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Mixed dentition Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.80 [0.55, 1.15] | NR | Ungraded |
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence) Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · Life expectancy: 71-75 years A systematic review and meta-analysis on early-childhood-caries global data. (2024) | MEAN 5.18 | NR | Ungraded |
Cesarean section delivery vs Vaginal delivery Early childhood caries (ECC) · Children aged <6 years · Study location: Europe RETRACTED: The association between mode of childbirth delivery and early childhood caries: A comprehensive… (2024) | OR 1.48 [0.83, 2.63] | 5 studies | Ungraded |
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence) Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Gini index: no inequality A systematic review and meta-analysis on early-childhood-caries global data. (2024) | Prevalence 62 | NR | Ungraded |
Cleft lip and palate vs No cleft lip and palate Lactobacillus spp. mean levels/counts · Children and adolescents aged 0 to 18 years with nonsyndromic cleft lip and palate Characterization of the oral microbiota and the relationship of the oral microbiota with the dental and… (2024) | MD 1.40 [1.33, 1.47] | 2 studies · 152 participants | Ungraded |
Overweight vs Normal weight (eutrophic) Dental caries experience (DMFT), continuous · Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts) Overweight/obesity and dental caries in Brazilian children and adolescents: a systematic review and… (2024) | MD -0.06 [-1.03, 0.91] | 2 studies · 446 participants | Very low |
TT+TC genotypes vs CC genotype Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Real-time quantitative PCR genotyping Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.87 [0.47, 1.61] | NR | Ungraded |
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence) Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Region: Africa A systematic review and meta-analysis on early-childhood-caries global data. (2024) | Prevalence 42 [32, 53] | 3 studies | Ungraded |
Intervention NR Overall success (composite of clinical and radiographic success) · Full pulpotomy, irreversible pulpitis Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis… (2024) | Proportion 0.837 [0.741, 0.916] | 12 studies | Ungraded |
Started toothbrushing with fluoride toothpaste at or before 24 months (earlier start) vs Started after 24 months (later start) Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years) Topical fluoride as a cause of dental fluorosis in children (2024) · Cochrane | RR 0.83 [0.61, 1.13] | 1 study · 3939 participants | Very low |
Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs Standard care dmft index score · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane | dmft was listed in the SoF table but not assessed (not reported for this comparison). | 0 studies | No studies |
Oral cancer patients (cases) vs Healthy controls Mean number of missing teeth in OC cases vs controls · Adults in case-control studies (oral cancer patients vs healthy controls) · Not specified, Missing teeth (mean count) Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. (2024) | SMD 0.59 [-0.04, 1.22] | 3 studies | Ungraded |
Intervention NR Decayed, missing, filled surfaces (DMFS) · Percentage of sites with CAL >=3 mm (tertiles); single study (Robert 2019); adjusted Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024) | OR 1.03 [1.00, 1.05] | 1 study | Ungraded |
Intervention NR Serum vitamin D (25(OH)D): ECC vs caries-free · Cross-sectional studies (Fig 3) The Association Between Vitamin D and Early Childhood Caries: A Systematic Review and Meta-Analysis. (2024) | Mean difference -6.10 [-8.02, -4.19] | 3 studies | Ungraded |
Presence of oral Candida albicans vs Absence of oral Candida albicans Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Region: Asia RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A… (2024) | OR 3.62 [2.53, 5.20] | 12 studies · 2347 participants | Ungraded |
Probiotics (any strain, dose, or presentation), minimum intake duration 0.2 months vs No treatment or placebo (control) Lactobacillus count (CFU/mL) · Children and/or adolescents (<18 years) without background systemic disease · follow-up: mean 5.2 months, Overall (all presentations pooled) Efficacy of Probiotic Consumption on Oral Outcomes in Children and/or Adolescents: A Meta-Analysis. (2024) | MD -0.78 [-1.65, 0.09] | 6 studies · 1143 participants | Very low |
Maternal smoking during pregnancy vs No maternal smoking during pregnancy Dental caries · Children · Study region: Australia Maternal smoking during pregnancy and early childhood dental caries in children: a systematic review and… (2024) | OR 1.68 [1.35, 2.10] | 1 study | Ungraded |
Serum 25(OH)D 50–75 nmol/l vs Serum 25(OH)D ≥ 75 nmol/l Early childhood caries (ECC) · Preschool children ≤6 years The Association Between Vitamin D and Early Childhood Caries: A Systematic Review and Meta-Analysis. (2024) | OR 1.42 [1.26, 1.60] | 6 studies · 5746 participants | Ungraded |
CO2 laser combined with fluoride vs Fluoride alone Enamel demineralization / mineral loss · Human enamel specimens under cariogenic challenge (in situ / ex vivo) Clinical and ex-vivo effect of LASERs on prevention of early-enamel caries: systematic review & meta-analyses. (2024) | Narrative only (secondary question: laser-fluoride synergy). Takate: combined low-power CO2 laser plus 1.23% APF gave greater inhibition of mineral loss than either alone (APF after laser gave maximum inhibition).… | 2 studies | Ungraded |
M2 Demirjian stages F-G vs M2 Demirjian stages E-D Spontaneous space closure · Children and adolescents with maxillary permanent first molar extraction · Follow-up to complete eruption of the permanent second molar, Maxilla Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR >100.00 [0.01, >100.00] | 3 studies | Ungraded |
Highest BMI category (overweight/obese) vs Lowest BMI category (normal weight/underweight) Dental caries / early childhood caries (ECC) · Children (approx. 4-18 years) · Sample size: >900 Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… (2024) | OR 1.59 [1.25, 2.02] | 8 studies | Ungraded |
Remineralizing orthodontic adhesives vs Control orthodontic adhesives Ion release · Human teeth with early enamel lesions surrounding orthodontic brackets · 14 days to 6 months Remineralization and anti-demineralization effect of orthodontic adhesives on enamel surrounding orthodontic… (2024) | no estimate extracted | 8 studies | Ungraded |