All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
In prospective cohorts, the multivariable-adjusted HR for all-cause mortality in edentulous adults (0 teeth) vs adults with 1-32 teeth was 1.30 (95% CI 1.21 to 1.40; 7 studies, I2=20%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
4 findings from 1 review
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Restoration failure · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6 to 12 years)
Direct composite resin restoration may leads to higher restoration failure rate compared with amalgam restoration (low certainty).
3 findings from 1 review
Quality of life · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
The review found no eligible studies for this question.
1 finding from 1 review
Optical/esthetic improvement (visual-tactile assessment) · Patients with post-orthodontic white spot lesions (WSL)
Resin infiltration produced significantly greater optical improvement of white spot lesions than untreated (naturally remineralizing) controls (SMD 1.24, 95% CI 0.59 to 1.88; moderate certainty).
4 findings from 1 review
SMD 1.24 [0.59, 1.88]
3 studies · 949 participants
Moderate
SMD 2.34 [1.68, 3.01]
1 study · 66 participants
GRADE not reported
SMD 0.63 [0.26, 1.01]
1 study · 115 participants
GRADE not reported
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Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces
In in vivo, laser fluorescence (DIAGNOdent 2095) pooled diagnostic odds ratio was 18.33 (95% CI 7.57 to 44.37) for occlusal caries at the caries detection level; ungraded.
4 findings from 1 review
DOR 18.33 [7.57, 44.37]
1 study
GRADE not reported
Sensitivity 0.88 [0.81, 0.93]
1 study
GRADE not reported
Specificity 0.71 [0.55, 0.83]
1 study
GRADE not reported
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AUC 0.88
1 study
GRADE not reported
Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)
Under in vitro conditions, sensor-based digital bitewing radiography had a pooled diagnostic odds ratio of 12.84 (95% CI 6.56, 25.13) for proximal caries detection at the dentin detection level; ungraded.
4 findings from 1 review
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Dental erosion prevalence · Five-year-old preschool children in Sharjah
One study found a high prevalence of dental erosion (58.8%) among 5-year-olds in Sharjah, associated with non-Emirati nationality, caries experience and sugary/carbonated beverage consumption (narrative synthesis; not GRADE-rated).
1 finding from 1 review
Among 5-year-olds in Sharjah (n=403), Gopinath reported dental erosion in 58.8% and dissolution of enamel in 55.0% (exposed dentin 3.7%). Predictors of erosion included Arab non-Emirati nationality (OR 0.27, 95% CI…
1 study · 403 participants
GRADE not reported
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, visual examination pooled sensitivity was 0.46 (95% CI 0.20 to 0.73) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
Sensitivity 0.46 [0.20, 0.73]
8 studies
GRADE not reported
Specificity 0.87 [0.72, 0.95]
8 studies
GRADE not reported
DOR 5.93 [3.11, 11.31]
8 studies
GRADE not reported
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AUC 0.79
8 studies
GRADE not reported
Intervention not reported
Dental caries prevalence · General population (children and adults) in East Africa
The pooled prevalence of dental caries in East Africa (2000-2020) was 45.7% (95% CI 38.0 to 53.4); certainty not graded.
1 finding from 1 review
Care index · Preschool children attending Al Ain pediatric dentistry department
The care index was 6.4%.
1 finding from 1 review
Complications (e.g. discomfort, pain and swelling) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…
1 finding from 1 review
1 trial (Scheyer 2016) reported moderate glazing, redness and oedema, while 2 trials (Santana 2019; Serrano Mendez 2017) reported there were no adverse events
3 studies · 87 participants
Low
Harms (discomfort, pain intensity, analgesia use) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
1 finding from 1 review
No clear difference in discomfort/pain intensity or analgesia consumption between vibrational appliance and control (Miles 2012, Miles 2016, Woodhouse 2015; 100 mm VAS). Narrative; no pooled estimate.
2 studies
GRADE not reported
Restoration survival · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)
Rubber dam isolation and moisture control (alone or with saliva… may leads to higher survival rate of restorations (6 months) compared with cotton rolls (with or without saliva aspiration) (low certainty).
4 findings from 1 review
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Sensitivity · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or extracted teeth of…
1 finding from 1 review
Electrical conductance for the detection of dental caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies)
CarieScan Pro (3 studies, 244 tooth surfaces): sensitivity ranged from 0.55 to 0.91. No evidence of a difference in accuracy by device type (Chi2=0.05, df=1, P=0.82).
3 studies
GRADE not reported
Success rate at 1 year · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…
It is very uncertain whether super ethoxybenzoic acid (Super-EBA) changes success rate at 1 year compared with intermediate restorative material (IRM) (very low certainty).
1 finding from 1 review
RR 0.90 [0.80, 1.01]
1 study
Very low
Water samples with fluoride concentration below the acceptable range · Brazilian cities in the Southeast region with artificially fluoridated public water supplies
In the Southeast region, 24.6% of samples were below the acceptable range.
1 finding from 1 review
Prevalence 24.6
Studies not reported
GRADE not reported
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
In prospective cohorts, adults with 17-24 teeth had a higher cumulative incidence of ACVD-related events than adults with 25-32 teeth (RR 1.73, 95% CI 1.22 to 2.45; 4 cohort studies, I2=87%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
1 finding from 1 review
All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
In prospective cohorts, the crude HR for all-cause mortality in adults with 0-19 teeth vs adults with 20-32 teeth was 2.47 (95% CI 2.40 to 2.54; 2 studies, I2=0%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
4 findings from 1 review
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Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)
Under in vitro conditions, phosphor-plate digital bitewing radiography had a summary ROC AUC of 0.82 for proximal caries detection at the caries detection level; ungraded.
4 findings from 1 review
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Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo)
Under in vivo conditions, conventional E-speed bitewing radiography had a pooled specificity of 0.91 (95% CI 0.80, 0.96) for proximal caries detection at the dentin detection level; ungraded.
4 findings from 1 review
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