What do systematic reviews say?

36 questions · 36 findings · 32 reviews · Pain, Palliative and Supportive Care

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No studies found 10 · 27.8%GRADE not reported 2 · 5.6%Very low 22 · 61.1%Low 2 · 5.6%Moderate 0 · 0%High 0 · 0%

High‐concentration (8%) capsaicin patch vs control patch (0.4%)

Death · adults with postherpetic neuralgia

1 finding from 1 review

Topical capsaicin (high concentration) for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 2487 participants
Very low

Gabapentin vs placebo

Death · adults with neuropathic pain

1 finding from 1 review

Gabapentin for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Morphine vs placebo

Death · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 289 participants
Very low

NSAIDs vs placebo

Death · adults with fibromyalgia

1 finding from 1 review

Oral nonsteroidal anti‐inflammatory drugs for fibromyalgia in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Death · people with cancer pain

1 finding from 1 review

Oral nonsteroidal anti‐inflammatory drugs (NSAIDs) for cancer pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 949 participants
Very low

Oxycodone MR vs placebo

Death · adults with neuropathic pain (2 studies in peripheral diabetic neuropathy and 1 study in postherpetic neuralgia)

1 finding from 1 review

Oxycodone for neuropathic pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 680 participants
Very low

Pregabalin vs placebo

Death · adults with fibromyalgia enrolled in EERW studies

1 finding from 1 review

Pregabalin for pain in fibromyalgia in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 687 participants
Very low

Pregabalin vs placebo

Death · adults with fibromyalgia

1 finding from 1 review

Pregabalin for pain in fibromyalgia in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 3460 participants
Very low

Intervention not reported

Death · adults with fibromyalgia

The review found no eligible studies for this question.

1 finding from 1 review

Milnacipran for pain in fibromyalgia in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Death · adults with fibromyalgia

The review found no eligible studies for this question.

1 finding from 1 review

Amitriptyline for fibromyalgia in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Death · adults with neuropathic pain (Trigeminal neuralgia, painful diabetic neuropathy, chronic post stroke pain)

1 finding from 1 review

Carbamazepine for chronic neuropathic pain and fibromyalgia in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Very low

Intervention not reported

Death · Adults with cancer pain

1 finding from 1 review

Codeine, alone and with paracetamol (acetaminophen), for cancer pain 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Death · neuropathic pain (5 studies in painful diabetic neuropathy and polyneuropathy)

1 finding from 1 review

Imipramine for neuropathic pain in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 168 participants
Very low

Intervention not reported

Death · neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke…

1 finding from 1 review

Levetiracetam for neuropathic pain in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Death · adults with peripheral neuropathic pain conditions

1 finding from 1 review

Topical lidocaine for neuropathic pain in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 210 participants
GRADE not reported

Intervention not reported

Death · adults with neuropathic pain (3 studies in painful diabetic neuropathy and postherpetic neuralgia)

1 finding from 1 review

Desipramine for neuropathic pain in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 177 participants
GRADE not reported

Intervention not reported

Death · adults with complex regional pain syndrome type 1 (lower limb)

The review found no eligible studies for this question.

1 finding from 1 review

Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Gabapentin vs placebo

Deaths · adults with fibromyalgia

1 finding from 1 review

Gabapentin for fibromyalgia pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Very low

Methadone vs placebo

Deaths · adults with chronic neuropathic pain

1 finding from 1 review

Methadone for neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Oral hydromorphone vs placebo

Deaths · adults with chronic neuropathic pain

The review found no eligible studies for this question.

1 finding from 1 review

Hydromorphone for neuropathic pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found