Cochrane Review Group
Drugs and Alcohol
61 systematic reviews in Drugs and Alcohol ask 731 questions. 7.8% have no studies to answer them, 25.4% rest on very low certainty evidence and 28.7% reach moderate or high certainty.
Reviews
61
Questions
731
current versions
No studies
7.8%
Moderate or high
28.7%
No studies 57 · 7.8%Ungraded 39 · 5.3%Very low 186 · 25.4%Low 239 · 32.7%Moderate 171 · 23.4%High 39 · 5.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Thinnest evidence
All no studies and very low questions| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Summary of findings table – disulfiram vs naltrexone Continuous abstinence from cocaine (number of participants who had achieved and maintained abstinence for at least three weeks at the end of treatment) · people with cocaine dependence Disulfiram for the treatment of cocaine dependence (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table – disulfiram vs naltrexone Point abstinence (number of participants who were abstinent at the end of the treatment) · people with cocaine dependence Disulfiram for the treatment of cocaine dependence (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table – disulfiram vs naltrexone Dropout for any reason (number of participants who did not complete treatment) · people with cocaine dependence Disulfiram for the treatment of cocaine dependence (2024) · Cochrane | RR 0.86 [0.56, 1.32] | 3 studies · 131 participants | Very low |
Summary of findings table – disulfiram vs naltrexone Dropout due to adverse events (number of participants who did not complete treatment due to adverse events) · people with cocaine dependence Disulfiram for the treatment of cocaine dependence (2024) · Cochrane | RR 0.5 [0.07, 3.55] | 1 study · 8 participants | Very low |
Summary of findings table – disulfiram vs naltrexone Any adverse events (number of participants who experienced at least one adverse event) · people with cocaine dependence Disulfiram for the treatment of cocaine dependence (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table – disulfiram vs placebo or no pharmacological treatment Dropout due to adverse events (number of participants who did not complete treatment due to adverse events) · people with cocaine dependence Disulfiram for the treatment of cocaine dependence (2024) · Cochrane | RR 12.97 [0.77, 218.37] | 1 study · 67 participants | Very low |
Summary of findings table – disulfiram vs placebo or no pharmacological treatment Any adverse events (number of participants who experienced at least one adverse event) · people with cocaine dependence Disulfiram for the treatment of cocaine dependence (2024) · Cochrane | RR 3 [0.35, 25.68] | 1 study · 30 participants | Very low |
Summary of findings table ‐ Any psychosocial intervention vs treatment Point abstinence, longest · adults with stimulant use disorder Psychosocial interventions for stimulant use disorder (2024) · Cochrane | RR 1.31 [0.86, 1.99] | 2 studies · 124 participants | Very low |
Summary of findings table ‐ Any psychosocial intervention vs treatment Continuous abstinence, longest · adults with stimulant use disorder Psychosocial interventions for stimulant use disorder (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Any psychosocial intervention vs treatment Number of drinks per day ‐ total · stopping or reducing alcohol consumption during pregnancy Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy (2024) · Cochrane | no estimate extracted | 2 studies · 157 participants | Very low |
Summary of findings table ‐ Any psychosocial intervention vs treatment Adverse events ‐ not measured · stopping or reducing alcohol consumption during pregnancy Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Any psychosocial intervention vs treatment Withdrawal signs and symptoms ‐ not measured · stopping or reducing alcohol consumption during pregnancy Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy (2024) · Cochrane | no estimate extracted | NR | No studies |
Reviews 61
Efficacy of psychostimulant drugs for amphetamine abuse or dependence
CochraneSoF table
3 questions
Oral naltrexone maintenance treatment for opioid dependence
CochraneSoF table
3 questions
Antidepressants for cocaine dependence and problematic cocaine use
CochraneSoF table
3 questions
Psychosocial combined with agonist maintenance treatments versus agonist maintenance treatments alone for treatment of opioid dependence
CochraneSoF table
5 questions
Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification
CochraneSoF table
6 questions
Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal
CochraneSoF table
8 questions
Benzodiazepines for alcohol withdrawal
CochraneSoF table
9 questions
Anticonvulsants for alcohol withdrawal
CochraneSoF table
8 questions
Gamma‐hydroxybutyrate (GHB) for treatment of alcohol withdrawal and prevention of relapses
CochraneSoF table
21 questions
Pharmacological treatment for depression during opioid agonist treatment for opioid dependence
CochraneSoF table
17 questions
Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence
CochraneSoF table
5 questions