Cochrane · systematic review · CD006266
Gamma‐hydroxybutyrate (GHB) for treatment of alcohol withdrawal and prevention of relapses
Leone, MA, Vigna‐Taglianti, F, Avanzi, G, et al. · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
21
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 10 · 47.6%Low 10 · 47.6%Moderate 1 · 4.8%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
GHB 50mg vs placebo be used for alcohol withdrawal
Population: patients with alcohol withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
withdrawal score ‐ 7 hours GHB 50mg vs placebo be used | no estimate extracted | 1 study · 23 participants | Very low Downgraded: imprecision |
side‐effects ‐ tolerated side‐effects GHB 50mg vs placebo be used | RR 16.25 [1.04, 254.98] | 1 study · 23 participants | Low Downgraded: imprecision |
GHB 50mg vs diazepam be used for alcohol withdrawal
Population: patients with alcohol withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
CIWA‐Ar score ‐ day 5 GHB 50mg vs diazepam be used | no estimate extracted | 1 study · 48 participants | Very low Downgraded: risk of bias |
GHB 50mg vs clomethiazole be used for alcohol withdrawal
Population: patients with alcohol withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
points withdrawal scale ‐ 7 hours GHB 50mg vs clomethiazole be used | no estimate extracted | 1 study · 21 participants | Very low Downgraded: risk of bias |
CIWA‐Ar score ‐ day 8 GHB 50mg vs clomethiazole be used | no estimate extracted | 1 study · 59 participants | Low Downgraded: risk of bias, imprecision |
side‐effects ‐ side‐effects causing abandon GHB 50mg vs clomethiazole be used | RR 0.33 [0.01, 7.9] | 1 study · 66 participants | Low Downgraded: risk of bias, imprecision |
GHB 100mg vs clomethiazole be used for alcohol withdrawal
Population: patients with alcohol withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
CIWA‐Ar score ‐ day 8 GHB 100mg vs clomethiazole be used | no estimate extracted | 1 study · 55 participants | Low Downgraded: imprecision |
side‐effects ‐ side‐effects causing abandon GHB 100mg vs clomethiazole be used | RR 1.03 [0.07, 15.79] | 1 study · 65 participants | Low Downgraded: imprecision |
GHB 50mg vs GHB 100 mg be used for alcohol withdrawal
Population: patients with alcohol withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
CIWA‐Ar score ‐ day 8 GHB 50mg vs GHB 100 mg be used | no estimate extracted | 1 study · 60 participants | Low Downgraded: imprecision |
side‐effects ‐ side‐effects causing abandon GHB 50mg vs GHB 100 mg be used | RR 0.32 [0.01, 7.66] | 1 study · 65 participants | Low Downgraded: imprecision |
GHB 50mg vs placebo be used in alcohol dependent patients
Population: alcohol dependent patients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
abstinence ‐ 6 months GHB 50mg vs placebo be used | RR 1.33 [0.58, 3.07] | 1 study · 17 participants | Low Downgraded: imprecision |
relapse to heavy drinking ‐ 6 months GHB 50mg vs placebo be used | RR 0.44 [0.05, 4.02] | 1 study · 17 participants | Low Downgraded: imprecision |
craving score ‐ 3 months GHB 50mg vs placebo be used | no estimate extracted | 1 study · 71 participants | Low Downgraded: imprecision |
GHB 50mg vs NTX be used in alcohol dependent patients
Population: alcohol dependent patients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
abstinence ‐ 12 months GHB 50mg vs NTX be used | RR 1.34 [0.83, 2.16] | 1 study · 55 participants | Very low Downgraded: risk of bias |
relapses to heavy drinking ‐ 12 months GHB 50mg vs NTX be used | RR 0.55 [0.18, 1.67] | 1 study · 55 participants | Very low Downgraded: risk of bias |
Alcohol Craving Scale ‐ 12 months GHB 50mg vs NTX be used | no estimate extracted | 1 study · 40 participants | Very low Downgraded: risk of bias |
side‐effects ‐ side‐effects causing abandon GHB 50mg vs NTX be used | RR 0.62 [0.18, 2.1] | 3 studies · 127 participants | Moderate Downgraded: risk of bias |
GHB 50mg vs disulfiram be used in alcohol dependent patients
Population: alcohol dependent patients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
abstinence ‐ 12 months GHB 50mg vs disulfiram be used | RR 1.66 [0.99, 2.8] | 1 study · 59 participants | Very low |
relapses to heavy drinking ‐ 12 months GHB 50mg vs disulfiram be used | RR 1.48 [0.36, 6.03] | 1 study · 59 participants | Very low |
Alcohol Craving Scale ‐ 12 months GHB 50mg vs disulfiram be used | no estimate extracted | 1 study · 41 participants | Very low |
side‐effects ‐ side‐effects causing abandon GHB 50mg vs disulfiram be used | RR 0.55 [0.11, 2.79] | 1 study · 59 participants | Very low |