Cochrane Review Group

Drugs and Alcohol

61 systematic reviews in Drugs and Alcohol ask 731 questions. 7.8% have no studies to answer them, 25.4% rest on very low certainty evidence and 28.7% reach moderate or high certainty.

Reviews

Questions

731

current versions

No studies

7.8%

Moderate or high

28.7%

No studies 57 · 7.8%Ungraded 39 · 5.3%Very low 186 · 25.4%Low 239 · 32.7%Moderate 171 · 23.4%High 39 · 5.3%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Drugs and Alcohol

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Summary of findings table – disulfiram vs naltrexone Continuous abstinence from cocaine (number of participants who had achieved and maintained abstinence for at least three weeks at the end of treatment) · people with cocaine dependence Disulfiram for the treatment of cocaine dependence (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table – disulfiram vs naltrexone Point abstinence (number of participants who were abstinent at the end of the treatment) · people with cocaine dependence Disulfiram for the treatment of cocaine dependence (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table – disulfiram vs naltrexone Dropout for any reason (number of participants who did not complete treatment) · people with cocaine dependence Disulfiram for the treatment of cocaine dependence (2024) · Cochrane	RR 0.86 [0.56, 1.32]	3 studies · 131 participants	Very low
Summary of findings table – disulfiram vs naltrexone Dropout due to adverse events (number of participants who did not complete treatment due to adverse events) · people with cocaine dependence Disulfiram for the treatment of cocaine dependence (2024) · Cochrane	RR 0.5 [0.07, 3.55]	1 study · 8 participants	Very low
Summary of findings table – disulfiram vs naltrexone Any adverse events (number of participants who experienced at least one adverse event) · people with cocaine dependence Disulfiram for the treatment of cocaine dependence (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table – disulfiram vs placebo or no pharmacological treatment Dropout due to adverse events (number of participants who did not complete treatment due to adverse events) · people with cocaine dependence Disulfiram for the treatment of cocaine dependence (2024) · Cochrane	RR 12.97 [0.77, 218.37]	1 study · 67 participants	Very low
Summary of findings table – disulfiram vs placebo or no pharmacological treatment Any adverse events (number of participants who experienced at least one adverse event) · people with cocaine dependence Disulfiram for the treatment of cocaine dependence (2024) · Cochrane	RR 3 [0.35, 25.68]	1 study · 30 participants	Very low
Summary of findings table ‐ Any psychosocial intervention vs treatment Point abstinence, longest · adults with stimulant use disorder Psychosocial interventions for stimulant use disorder (2024) · Cochrane	RR 1.31 [0.86, 1.99]	2 studies · 124 participants	Very low
Summary of findings table ‐ Any psychosocial intervention vs treatment Continuous abstinence, longest · adults with stimulant use disorder Psychosocial interventions for stimulant use disorder (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Any psychosocial intervention vs treatment Number of drinks per day ‐ total · stopping or reducing alcohol consumption during pregnancy Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy (2024) · Cochrane	no estimate extracted	2 studies · 157 participants	Very low
Summary of findings table ‐ Any psychosocial intervention vs treatment Adverse events ‐ not measured · stopping or reducing alcohol consumption during pregnancy Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Any psychosocial intervention vs treatment Withdrawal signs and symptoms ‐ not measured · stopping or reducing alcohol consumption during pregnancy Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy (2024) · Cochrane	no estimate extracted	NR	No studies

Reviews 61

Disulfiram for the treatment of cocaine dependence

Traccis, F, Minozzi, S, et al. · Cochrane Database of Systematic Reviews · 2024

Drugs and Alcohol

Thinnest evidence

Reviews 61

Disulfiram for the treatment of cocaine dependence

Psychosocial interventions for stimulant use disorder

Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy

Motivational interviewing for substance use reduction

Baclofen for alcohol use disorder

Psychosocial and pharmacologic interventions to reduce harmful alcohol use in low‐ and middle‐income countries

Opioid agonist treatment for people who are dependent on pharmaceutical opioids

Music therapy for people with substance use disorders

Mindfulness‐based interventions for substance use disorders

Effectiveness of psychosocial interventions for reducing parental substance misuse

Maintenance agonist treatments for opiate‐dependent pregnant women

Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders

Alcoholics Anonymous and other 12‐step programs for alcohol use disorder

Baclofen for alcohol withdrawal

Pharmacotherapies for cannabis dependence

Psychological interventions for co‐occurring depression and substance use disorders

Interventions for drug‐using offenders with co‐occurring mental health problems

Interventions for female drug‐using offenders

Family‐based prevention programmes for alcohol use in young people

Effectiveness of brief alcohol interventions in primary care populations

Pharmacological therapies for management of opium withdrawal

Antidepressants for the treatment of people with co‐occurring depression and alcohol dependence

Psychosocial interventions to reduce alcohol consumption in concurrent problem alcohol and illicit drug users

Cognitive‐behavioural treatment for amphetamine‐type stimulants (ATS)‐use disorders

Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users