Cochrane · systematic review · CD012254
Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders
Carney, T, Van Hout, MC, Norman, I, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 8 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Dihydrocodeine compared to buprenorphine for detoxification in illicit‐opiate‐dependent individuals
Population: individuals dependent on illicit opiates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Abstinence Assessed by urinalysis post‐detoxification Dihydrocodeine vs buprenorphine | RR 0.42 [0.11, 1.57] | 2 studies · 150 participants | Low Downgraded: risk of bias, imprecision |
Abstinence Self‐report and urinalysis 3 months post‐detoxification Dihydrocodeine vs buprenorphine | RR 0.59 [0.26, 1.31] | 2 studies · 150 participants | Low Downgraded: risk of bias, imprecision |
Abstinence Self‐report and urinalysis 6 months post‐detoxification Dihydrocodeine vs buprenorphine | RR 0.59 [0.25, 1.39] | 2 studies · 150 participants | Low Downgraded: risk of bias, imprecision |
Serious adverse events or adverse events Dihydrocodeine vs buprenorphine | no estimate extracted | 2 studies · 150 participants | Low Downgraded: risk of bias, imprecision |
Treatment retention Early dropout Dihydrocodeine vs buprenorphine | RR 1.29 [0.99, 1.68] | 2 studies · 150 participants | Low Downgraded: risk of bias, imprecision |
Dihydrocodeine compared to methadone for substitution therapy in illicit‐opiate‐dependent individuals
Population: individuals dependent on illicit opiates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Abstinence Dihydrocodeine vs methadone | no estimate extracted | 1 study · 204 participants | Low Downgraded: risk of bias, imprecision |
Serious adverse events or adverse events Death due to methadone use Dihydrocodeine vs methadone | no estimate extracted | 1 study · 204 participants | Low Downgraded: risk of bias, imprecision |
Treatment retention Dihydrocodeine vs methadone | RR 1.04 [0.94, 1.16] | 1 study · 204 participants | Low Downgraded: risk of bias, imprecision |