Cochrane · systematic review · CD013350
Psychosocial and pharmacologic interventions to reduce harmful alcohol use in low‐ and middle‐income countries
Greene, MC, Kane, J, Alto, M, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
11
No studies
2
Included studies
NR
No studies 2 · 13.3%Ungraded 2 · 13.3%Very low 6 · 40%Low 4 · 26.7%Moderate 1 · 6.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Pharmacologic intervention compared to placebo for individuals with alcohol use disorder
Population: individuals with alcohol use disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Harmful alcohol use Pharmacologic intervention vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Retention Pharmacologic intervention vs placebo | RR 1.13 [0.89, 1.44] | 3 studies · 247 participants | Low |
Pharmacologic intervention along with psychosocial intervention compared to psychosocial intervention alone for individuals with alcohol use disorder
Population: individuals with alcohol use disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Harmful alcohol use (continuous) Pharmacologic intervention along with psychosocial intervention vs psychosocial intervention alone | no estimate extracted | 4 studies · 475 participants | Low Downgraded: risk of bias |
Harmful alcohol use (dichotomous) Pharmacologic intervention along with psychosocial intervention vs psychosocial intervention alone | RR 0.62 [0.16, 2.47] | 1 study · 102 participants | Very low Downgraded: risk of bias |
Retention Pharmacologic intervention along with psychosocial intervention vs psychosocial intervention alone | RR 1.15 [0.95, 1.4] | 3 studies · 363 participants | Moderate Downgraded: risk of bias, imprecision |
Pharmacologic intervention compared to another pharmacologic intervention for individuals with alcohol use disorder
Population: individuals with alcohol use disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Harmful alcohol use ‐ not measured Pharmacologic intervention vs another pharmacologic intervention | no estimate extracted | NR | No studies |
Retention Pharmacologic intervention vs another pharmacologic intervention | RR 0.95 [0.76, 1.19] | 2 studies · 190 participants | Low |
Pharmacologic intervention compared to another pharmacologic intervention in addition to psychosocial intervention for individuals with alcohol use disorder
Population: individuals with alcohol use disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Harmful alcohol use ‐ not measured Pharmacologic intervention vs another pharmacologic intervention | no estimate extracted | NR | No studies |
Retention Pharmacologic intervention vs another pharmacologic intervention | RR 1.02 [0.96, 1.08] | 2 studies · 200 participants | Low |
Different comparators Pharmacologic intervention vs another pharmacologic intervention | no estimate extracted | 1 participants | Ungraded |
Brief interventions compared to brief advice, information, or assessment only for individuals with hazardous or harmful alcohol use
Population: individuals with hazardous or harmful alcohol use
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Harmful alcohol use (continuous) Brief interventions vs brief advice, information, or assessment only | no estimate extracted | 17 studies · 3913 participants | Very low Downgraded: risk of bias |
Harmful alcohol use (dichotomous) Brief interventions vs brief advice, information, or assessment only | no estimate extracted | 4 studies · 1349 participants | Very low Downgraded: risk of bias |
Retention Brief interventions vs brief advice, information, or assessment only | no estimate extracted | 12 studies · 5380 participants | Very low Downgraded: risk of bias |
Other psychosocial intervention compared to usual care, brief intervention, or wait list for individuals with hazardous or harmful alcohol use
Population: individuals with hazardous or harmful alcohol use
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Harmful alcohol use Other psychosocial intervention vs usual care, brief intervention, or wait list | no estimate extracted | 12 studies · 2106 participants | Very low Downgraded: risk of bias |
Retention Other psychosocial intervention vs usual care, brief intervention, or wait list | no estimate extracted | 9 studies · 1664 participants | Very low Downgraded: risk of bias |