Cochrane · systematic review · CD008581
Antidepressants for the treatment of people with co‐occurring depression and alcohol dependence
Agabio, R, Trogu, E, Pani, PP · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 4 · 57.1%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antidepressants compared to placebo: all studies for the treatment of people with co‐occurring depression and alcohol consumption
Population: people with co‐occurring depression and alcohol dependence
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Depression severity: final score (interviewer‐rated scales) Antidepressants vs placebo: all studies | no estimate extracted | 14 studies · 1074 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Response to antidepressive treatment Antidepressants vs placebo: all studies | RR 1.4 [1.08, 1.82] | 10 studies · 805 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Consumption of alcohol: abstinent days (%) Antidepressants vs placebo: all studies | no estimate extracted | 9 studies · 821 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Consumption of alcohol: abstinent participants (number) Antidepressants vs placebo: all studies | RR 1.71 [1.22, 2.39] | 7 studies · 424 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Consumption of alcohol: drinks (per drinking days) Antidepressants vs placebo: all studies | no estimate extracted | 7 studies · 451 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Acceptability: dropouts Antidepressants vs placebo: all studies | RR 0.98 [0.79, 1.22] | 17 studies · 1159 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Tolerability of treatment: withdrawal for medical reasons Antidepressants vs placebo: all studies | RR 1.15 [0.65, 2.04] | 10 studies · 947 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |