Cochrane · systematic review · CD007024
Disulfiram for the treatment of cocaine dependence
Traccis, F, Minozzi, S, Trogu, E, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
11
No studies
3
Included studies
NR
No studies 3 · 21.4%Ungraded 0 · 0%Very low 4 · 28.6%Low 7 · 50%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table – disulfiram compared to placebo or no pharmacological treatment for people with cocaine dependence
Population: people with cocaine dependence
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of cocaine use (mean number of days or weeks of cocaine use at the end of treatment) Summary of findings table – disulfiram vs placebo or no pharmacological treatment | no estimate extracted | 9 studies · 818 participants | Low Downgraded: risk of bias, inconsistency |
Amount of cocaine use (mean weight of cocaine used or money spent on cocaine at the end of treatment) Summary of findings table – disulfiram vs placebo or no pharmacological treatment | no estimate extracted | 5 studies · 376 participants | Low Downgraded: risk of bias, imprecision |
Continuous abstinence from cocaine (number of participants who had achieved and maintained abstinence for at least three weeks at the end of treatment) Summary of findings table – disulfiram vs placebo or no pharmacological treatment | RR 1.23 [0.8, 1.91] | 5 studies · 386 participants | Low Downgraded: risk of bias, imprecision |
Point abstinence (number of participants who were abstinent at the end of the treatment) Summary of findings table – disulfiram vs placebo or no pharmacological treatment | RR 1.58 [1.05, 2.36] | 2 studies · 142 participants | Low Downgraded: risk of bias, imprecision |
Dropout for any reason (number of participants who did not complete treatment) Summary of findings table – disulfiram vs placebo or no pharmacological treatment | RR 1.2 [0.92, 1.55] | 10 studies · 841 participants | Low Downgraded: risk of bias, imprecision |
Dropout due to adverse events (number of participants who did not complete treatment due to adverse events) Summary of findings table – disulfiram vs placebo or no pharmacological treatment | RR 12.97 [0.77, 218.37] | 1 study · 67 participants | Very low Downgraded: risk of bias, imprecision |
Any adverse events (number of participants who experienced at least one adverse event) Summary of findings table – disulfiram vs placebo or no pharmacological treatment | RR 3 [0.35, 25.68] | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision |
Summary of findings table – disulfiram compared to naltrexone for people with cocaine dependence
Population: people with cocaine dependence
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of cocaine use (mean number of days or weeks of cocaine use at the end of treatment) Summary of findings table – disulfiram vs naltrexone | no estimate extracted | 2 studies · 123 participants | Low Downgraded: risk of bias, imprecision |
Amount of cocaine use (mean weight of cocaine used or money spent on cocaine at the end of treatment) Summary of findings table – disulfiram vs naltrexone | no estimate extracted | 2 studies · 123 participants | Low Downgraded: risk of bias, imprecision |
Continuous abstinence from cocaine (number of participants who had achieved and maintained abstinence for at least three weeks at the end of treatment) Summary of findings table – disulfiram vs naltrexone | no estimate extracted | NR | No studies |
Point abstinence (number of participants who were abstinent at the end of the treatment) Summary of findings table – disulfiram vs naltrexone | no estimate extracted | NR | No studies |
Dropout for any reason (number of participants who did not complete treatment) Summary of findings table – disulfiram vs naltrexone | RR 0.86 [0.56, 1.32] | 3 studies · 131 participants | Very low Downgraded: risk of bias, imprecision |
Dropout due to adverse events (number of participants who did not complete treatment due to adverse events) Summary of findings table – disulfiram vs naltrexone | RR 0.5 [0.07, 3.55] | 1 study · 8 participants | Very low Downgraded: risk of bias, imprecision |
Any adverse events (number of participants who experienced at least one adverse event) Summary of findings table – disulfiram vs naltrexone | no estimate extracted | NR | No studies |