Cochrane · systematic review · CD007522
Pharmacological therapies for management of opium withdrawal
Rahimi‐Movaghar, A, Gholami, J, Amato, L, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
11
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 63.6%Low 4 · 36.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Pharmacological detoxification treatment compared to other pharmacological detoxification treatment for management of opium withdrawal
Population: management of opium withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Completion of treatment: baclofen versus clonidine Pharmacological detoxification treatment vs other pharmacological detoxification treatment | RR 1.06 [0.63, 1.8] | 66 participants | Very low Downgraded: risk of bias, imprecision |
Completion of treatment: clonidine versus clonidine plus amantadine, inpatient setting Pharmacological detoxification treatment vs other pharmacological detoxification treatment | RR 1.03 [0.86, 1.24] | 69 participants | Very low Downgraded: risk of bias, imprecision |
Completion of treatment: clonidine versus buprenorphine, inpatient setting Pharmacological detoxification treatment vs other pharmacological detoxification treatment | RR 1.04 [0.9, 1.2] | 35 participants | Very low Downgraded: risk of bias, imprecision |
Completion of treatment: clonidine versus methadone Pharmacological detoxification treatment vs other pharmacological detoxification treatment | RR 2.01 [1.69, 2.38] | 361 participants | Low Downgraded: risk of bias |
Completion of treatment: methadone versus tramadol Pharmacological detoxification treatment vs other pharmacological detoxification treatment | RR 0.95 [0.65, 1.37] | 72 participants | Very low Downgraded: risk of bias, imprecision |
Completion of treatment: methadone versus methadone plus gabapentin Pharmacological detoxification treatment vs other pharmacological detoxification treatment | RR 1.17 [0.96, 1.43] | 1 study · 40 participants | Low Downgraded: imprecision |
Completion of treatment: tincture of opium versus methadone Pharmacological detoxification treatment vs other pharmacological detoxification treatment | RR 1 [0.95, 1.05] | 1 study · 74 participants | Low Downgraded: imprecision |
Pharmacological detoxification treatment compared to other pharmacological detoxification treatment for management of opium withdrawal
Population: management of opium withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Withdrawal symptoms at day 3: clonidine versus clonidine plus amantadine, inpatient setting Pharmacological detoxification treatment vs other pharmacological detoxification treatment | no estimate extracted | 60 participants | Very low Downgraded: risk of bias, imprecision |
Withdrawal symptoms at day 3: clonidine versus buprenorphine,inpatient setting Pharmacological detoxification treatment vs other pharmacological detoxification treatment | no estimate extracted | 34 participants | Very low Downgraded: risk of bias, imprecision |
Withdrawal symptoms at day 3: methadone versus tramadol Pharmacological detoxification treatment vs other pharmacological detoxification treatment | no estimate extracted | 72 participants | Very low Downgraded: risk of bias, imprecision |
Withdrawal symptoms at day 3: methadone versus methadone plus gabapentin Pharmacological detoxification treatment vs other pharmacological detoxification treatment | no estimate extracted | 1 study · 40 participants | Low Downgraded: imprecision |