Cochrane · systematic review · CD002950
Antidepressants for cocaine dependence and problematic cocaine use
Pani, PP, Trogu, E, Vecchi, S, et al. · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 66.7%High 1 · 33.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antidepressants compared to placebo according to any definition for cocaine abuse and dependence
Population: patients with cocaine abuse and dependence
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dropout ‐ Dropouts: excluding studies with high risk of bias objective Antidepressants vs placebo according to any definition | RR 1.01 [0.91, 1.12] | 27 studies · 2417 participants | Moderate Downgraded: risk of bias |
Abstinence, for at least three consecutive weeks objective Antidepressants vs placebo according to any definition | RR 1.22 [0.99, 1.51] | 8 studies · 942 participants | High |
Adverse events ‐ Withdrawn due to adverse events Antidepressants vs placebo according to any definition | RR 1.39 [0.91, 2.12] | 13 studies · 1396 participants | Moderate Downgraded: risk of bias, imprecision |