Cochrane · systematic review · CD002209
Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence
Mattick, RP, Breen, C, Kimber, J, et al. · Cochrane Database of Systematic Reviews · 2009 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 40%High 3 · 60%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: patients with opioid dependence
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Retention in treatment ‐ Old studies (pre 2000) objective | RR 3.05 [1.75, 5.35] | 3 studies · 505 participants | High |
Retention in treatment ‐ New studies | RR 4.44 [3.26, 6.04] | 4 studies · 750 participants | High |
Morphine positive urine or hair analysis objective | RR 0.66 [0.56, 0.78] | 6 studies · 1129 participants | High |
Criminal activity objective | RR 0.39 [0.12, 1.25] | 3 studies · 363 participants | Moderate |
Mortality objective | RR 0.48 [0.1, 2.39] | 4 studies · 576 participants | Moderate |