Cochrane · systematic review · CD005063
Benzodiazepines for alcohol withdrawal
Amato, L, Minozzi, S, Vecchi, S, et al. · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 22.2%Moderate 5 · 55.6%High 2 · 22.2%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Benzodiazepine versus Placebo for alcohol withdrawal
Population: patients with alcohol withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Alcohol withdrawal seizures objective Benzodiazepine vs Placebo | RR 0.16 [0.04, 0.69] | 3 studies · 324 participants | Moderate Downgraded: risk of bias |
Adverse events Benzodiazepine vs Placebo | RR 3.28 [0.31, 34.52] | 2 studies · 71 participants | Low |
Dropouts Benzodiazepine vs Placebo | RR 0.68 [0.38, 1.24] | 3 studies · 312 participants | Moderate Downgraded: risk of bias |
Benzodiazepine versus Other Drug for
Population: patients with
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Alcohol withdrawal seizures ‐ Benzodiazepine vs. Other Drug Benzodiazepine vs Other Drug for | RR 0.52 [0.21, 1.31] | 12 studies · 1228 participants | Moderate Downgraded: risk of bias |
Alcohol withdrawal seizures ‐ Benzodiazepine vs. Anticonvulsant Benzodiazepine vs Other Drug for | RR 1.7 [0.39, 7.37] | 7 studies · 523 participants | Moderate |
Adverse events ‐ Benzodiazepine vs. Other Drug Benzodiazepine vs Other Drug for | RR 1.31 [0.99, 1.72] | 18 studies · 919 participants | Low |
Adverse events ‐ Benzodiazepine vs. Anticonvulsant Benzodiazepine vs Other Drug for | RR 1.5 [0.83, 2.7] | 9 studies · 471 participants | High |
Dropouts ‐ Benzodiazepine vs. Other Drug Benzodiazepine vs Other Drug for | RR 0.93 [0.7, 1.24] | 22 studies · 1848 participants | Moderate Downgraded: risk of bias |
Dropouts ‐ Benzodiazepine vs. Anticonvulsant Benzodiazepine vs Other Drug for | RR 1.11 [0.75, 1.63] | 11 studies · 839 participants | High |