Cochrane · systematic review · CD005064
Anticonvulsants for alcohol withdrawal
Minozzi, S, Amato, L, Vecchi, S, et al. · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 12.5%Moderate 7 · 87.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Anticonvulsant versus Placebo for alcohol withdrawal
Population: patients with alcohol withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Alcohol Withdrawal Seizures post treatment ‐ Any Anticonvulsant vs. Placebo Anticonvulsant vs Placebo | RR 0.61 [0.31, 1.2] | 9 studies · 883 participants | Moderate Downgraded: risk of bias |
Alcohol Withdrawal Seizures post treatment ‐ Phenytoin vs. Placebo Anticonvulsant vs Placebo | RR 0.78 [0.35, 1.77] | 4 studies · 381 participants | Moderate |
Adverse events Anticonvulsant vs Placebo | RR 1.56 [0.74, 3.31] | 7 studies · 663 participants | Moderate |
Dropout ‐ Any Anticonvulsant vs. Placebo Anticonvulsant vs Placebo | RR 0.82 [0.5, 1.34] | 7 studies · 344 participants | Moderate Downgraded: risk of bias |
Dropout ‐ Chlormethiazole vs. Placebo Anticonvulsant vs Placebo | RR 1.05 [0.22, 5.11] | 3 studies · 140 participants | Moderate |
Anticonvulsant versus Other Drugs for alcohol withdrawal
Population: patients with alcohol withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Alcohol withdrawal seizures ‐ Any Anticonvulsant vs any Other Anticonvulsant vs Other Drugs | RR 0.58 [0.22, 1.58] | 12 studies · 880 participants | Low Downgraded: risk of bias |
Adverse events ‐ Any Anticonvulsant vs any Other Anticonvulsant vs Other Drugs | RR 0.71 [0.45, 1.12] | 14 studies · 726 participants | Moderate Downgraded: risk of bias |
Dropout ‐ Any Anticonvulsant vs any Other Anticonvulsant vs Other Drugs | RR 0.92 [0.67, 1.26] | 20 studies · 1359 participants | Moderate Downgraded: risk of bias |