Cochrane · systematic review · CD002022
Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal
Gowing, L, Ali, R, White, JM · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 12.5%Very low 0 · 0%Low 2 · 25%Moderate 5 · 62.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: patients with opioid withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number completing detoxification | RR 1.42 [1.09, 1.84] | 2 studies · 100 participants | Low Downgraded: risk of bias, imprecision |
Number commencing naltrexone maintenance treatment ‐ Clonidine comparison | RR 4.28 [2.91, 6.3] | 3 studies · 240 participants | Moderate Downgraded: risk of bias, imprecision |
Number commencing naltrexone maintenance treatment ‐ Buprenorphine comparison | RR 1.29 [1.04, 1.6] | 1 study · 72 participants | Moderate Downgraded: risk of bias, imprecision |
Retained in naltrexone maintenance treatment or abstinent at 12 weeks ‐ Tapered methadone comparison | RR 2 [0.9, 4.45] | 1 study · 30 participants | Low Downgraded: risk of bias, imprecision |
Retained in naltrexone maintenance treatment or abstinent at 12 weeks ‐ Clonidine comparison | RR 2.77 [1.37, 5.61] | 3 studies · 240 participants | Moderate Downgraded: risk of bias, imprecision |
Retained in naltrexone maintenance treatment or abstinent at 12 weeks ‐ Buprenorphine comparison | RR 0.82 [0.34, 1.97] | 1 study · 72 participants | Moderate Downgraded: risk of bias, imprecision |
Comparison
Population: patients with opioid withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participants experiencing adverse effects | RR 3.21 [1.13, 9.12] | 2 studies · 572 participants | Moderate |
Less than 300 events | no estimate extracted | 1 participants | Ungraded |