Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

214 questions · 217 findings · 40 reviews · Pain, Palliative and Supportive Care · Headline outcomes only

No studies found 35 · 16.1%GRADE not reported 2 · 0.9%Very low 49 · 22.6%Low 43 · 19.8%Moderate 48 · 22.1%High 40 · 18.4%

Mirtazapine vs placebo

Participant‐reported pain relief of 30% or greater · adults with fibromyalgia

Mirtazapine may leads to higher participant‐reported pain relief of 30% or greater (moderate… compared with placebo (low certainty).

1 finding from 1 review

Morphine vs placebo

Any pain‐related outcome (moderate pain improvement) · adults with neuropathic pain

It is very uncertain whether morphine changes any pain‐related outcome (moderate pain improvement) compared with placebo (very low certainty).

1 finding from 1 review

NSAIDs vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with fibromyalgia

It is very uncertain whether NSAID changes moderate pain relief: at least 30% reduction in pain, or PGIC much… compared with placebo (very low certainty).

1 finding from 1 review

Methadone vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with chronic neuropathic pain
1 finding from 1 review

Oxycodone MR vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with neuropathic pain (2 studies in peripheral diabetic neuropathy and 1 study in postherpetic neuralgia)
1 finding from 1 review

Oral hydromorphone vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with chronic neuropathic pain

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Moderate benefit: at least 30% reduction in pain, or PGIC much or very much improved · Adults with chronic neuropathic pain
1 finding from 1 review

Pregabalin vs placebo

Maintenance of initial therapeutic response of at least 30% pain intensity reduction over baseline and continued treatment at 13 or 26 weeks (equivalent to 'moderate benefit') · adults with fibromyalgia enrolled in EERW studies
1 finding from 1 review