Cochrane · systematic review · CD010585
Combination pharmacotherapy for the treatment of fibromyalgia in adults
Thorpe, J, Shum, B, Moore, RA, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Any combination of two or more drugs compared with placebo or other comparators, or both, for fibromyalgia
Population: adults with fibromyalgia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Patient‐reported pain relief of 30% or greater Any combination of two or more drugs vs placebo or other comparators, or both, | no estimate extracted | NR | Very low |
Patient‐reported pain relief of 50% or greater Any combination of two or more drugs vs placebo or other comparators, or both, | no estimate extracted | NR | Very low |
Patient‐reported global impression of clinical change much or very much improved (moderate improvement) Any combination of two or more drugs vs placebo or other comparators, or both, | no estimate extracted | NR | Very low |
Any pain‐related outcome indicating some improvement Any combination of two or more drugs vs placebo or other comparators, or both, | no estimate extracted | NR | Very low |
Participants experiencing any adverse event Any combination of two or more drugs vs placebo or other comparators, or both, | no estimate extracted | NR | Very low |
Participants experiencing any serious adverse event Any combination of two or more drugs vs placebo or other comparators, or both, | no estimate extracted | NR | Very low |
Withdrawals due to adverse events Any combination of two or more drugs vs placebo or other comparators, or both, | no estimate extracted | NR | Very low |