Findings

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Evidence found and GRADE certainty

3,556 questions · 10,375 findings · 429 reviews · Oral Health

No studies found 1,344 · 13%GRADE not reported 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

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Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Dental development and maturation · Children and adolescents (<18 years) living with HIV (CLWH)

A single small study suggested delayed dental development in CLWH on ART, but the evidence was insufficient to draw conclusions (very low certainty).

1 finding from 1 review

Maternal education attainment vs Children without dental caries

Dental caries (association with secondary/higher maternal education) · Children (deciduous and/or permanent dentition) in low- and middle-income countries

Secondary/higher maternal education showed no significant association with dental caries (OR 0.96, 95% CI 0.64 to 1.44; 7 studies; not GRADE-rated).

1 finding from 1 review

Not applicable (single-group prevalence) vs Not applicable

Caries experience (mean DMFT) · Children aged 12 years (plus or minus one year) in Africa

The pooled mean DMFT score was 1.0900 (95% CI 0.9143 to 1.2657); GRADE was not reported.

2 findings from 1 review

Baby-led weaning (BLW) vs Traditional complementary feeding (TCF)

Infant weight-length gain (achievement of adequate weight) · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries

Baby-led weaning/BLISS did not significantly influence infant weight-length (adequate weight) gain versus other complementary feeding models (pooled OR 1.36, 95% CI 0.18 to 10.51; ungraded).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Oral hygiene · Children and adolescents (<18 years) living with HIV (CLWH)

Oral hygiene status did not differ significantly between CLWH with and without ART (very low certainty).

1 finding from 1 review

Common genetic variants genome-wide (GWAS; ~3.9 million SNPs with MAF > 5%) vs ECC-unaffected children (per-allele case-control association)

Early childhood caries (ECC) - association at lead SNP rs76823412 (8:134690570; nearest gene(s) ST3GAL1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)

The common variant rs8091366 near CHST9, KCTD1 showed suggestive (not genome-wide significant) association with ECC (Z = 4.476, p = 7.60e-6); genetic association, ungraded.

2 findings from 1 review

Silver diamine fluoride (SDF) vs placebo

Oral health-related quality of life · Children with dental caries

SDF did not significantly differ from placebo for oral health-related quality of life in children (MD 0.03, 95% CI -0.16 to 0.22; ungraded).

1 finding from 1 review

Food and nonalcoholic beverage marketing (exposure) vs No, less, or less powerful food marketing

Dental caries · Children and adolescents (general population, aged under 20 years)

Evidence on food marketing and dental caries is very uncertain (very low certainty); 1 of 2 studies found an association.

1 finding from 1 review

Traditional screening with motivation (oral health education and offer of free treatment) vs Traditional screening

Dental attendance · School children, primary and secondary schools in India

It is very uncertain whether traditional screening with motivation (oral health education and… changes dental attendance compared with traditional screening alone (very low certainty).

1 finding from 1 review

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) vs placebo or no treatment

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) probably leads to lower presence of dry socket compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

HVGIC Fuji IX Gold Label vs HVGIC Vitro Molar and Maxxion R

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; failure rates were tabulated.

1 finding from 1 review

Oral health education only (verbal, written, or audio-visual education) delivered by non-dental health workers vs control (no intervention/usual care/isotonic exercise)

Caries experience at the surface level (dmfs/defs) · Children (mean age newborn to ~5.2 years) and their parents/carers

Oral-health-education-only interventions did not show a statistically significant effect on surface-level caries (dmfs SMD -0.20, 95% CI -0.43 to 0.03; 2 studies; not GRADE-rated).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Angular cheilitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No eligible studies compared angular cheilitis between different ART regimens.

1 finding from 1 review

Atraumatic restorative treatment with GIC vs Conventional restoration

Restoration failure · Children (3-13 years) with dentine caries in primary teeth, no pulpal involvement

ART with GIC was reported to increase the odds of restoration failure versus conventional restoration (OR 1.60; ungraded).

1 finding from 1 review

Machine-learning algorithms for dental caries detection vs Different machine-learning algorithms for caries prediction

detection of proximal caries · Dental images of human beings

The review reported 85.6% accuracy for proximal caries in Casalegno et al. (Ungraded).

2 findings from 1 review

Caries in first and second primary molars vs Reference (other primary tooth locations / caries-free)

Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)

Caries in the first and second primary molars is the strongest tooth-specific predictor of caries in permanent teeth (RR 3.4; single study; not GRADE-rated).

1 finding from 1 review