Non-Cochrane · intervention · PM35104291
Silver diamine fluoride and oral health-related quality of life: A review and network meta-analysis.
Ruff Ryan Richard, Whittemore Rachel, Grochecki Martyna, et al. · PloS one · 2022 · PubMed · doi:10.1371/journal.pone.0261627
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
13
current version
GRADE rated
0
No studies
0
Included studies
10
linked below
No studies 0 · 0%Ungraded 13 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Subjects of any age with dental caries | Children (ages ~2-13 years in the pooled trials; 0-16 years across all included studies) with dental caries |
| Intervention | Silver diamine fluoride, as a single or combinative treatment for dental caries | SDF or SDF + fluoride varnish (SDF+FV) |
| Comparison | Any comparative intervention (e.g., atraumatic restorative treatments, glass ionomer sealants, amalgam restorations, fluoride varnish, or combinations); studies without a control/comparator were excluded from quantitative synthesis | Placebo, atraumatic restorative treatment (ART), or ART + fluoride varnish (ART+FV) |
| Outcomes | Quantitatively measured oral health-related quality of life using a validated instrument | OHRQoL measured by ECOHIS (A/B/C-ECOHIS) or COHIP-SF (4 ECOHIS and 1 COHIP among the 5 NMA studies) |
| Study designs | Randomized controlled trials, cohort studies, or case-control studies | 5 randomized controlled trials in meta-analysis (of 10 full-text studies: 5 RCTs, 3 cohort, 2 cross-sectional) |
| Timing | Not specified (no date or language restriction on studies) | Post-treatment OHRQoL (follow-up varied by trial) |
Search date: 30 July 2021. Databases: MEDLINE/PubMed, Web of Science, and Scopus (no grey-literature search)
Questions and results
Silver diamine fluoride (SDF, including SDF + fluoride varnish) vs Other standard-of-care caries treatments pooled (placebo, ART, or ART + fluoride varnish)
Population: Children with dental caries (ages ~2-13 years in the pooled trials)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Oral health-related quality of life (OHRQoL; ECOHIS/COHIP) Post-treatment (follow-up varied by trial) SDF had no significant effect on oral health-related quality of life versus pooled standard-of-care caries treatments (SMD -0.06, 95% CI -0.20 to 0.08; ungraded). Source: Fig 2 (fixed-effects meta-analysis); Results 3.2; Abstract · same question in other reviews | SMD -0.06 [-0.20, 0.08] | 5 studies · 820 participants | Ungraded |
Silver diamine fluoride (SDF) vs Placebo
Population: Children with dental caries (ages ~2-13 years in the pooled trials)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Oral health-related quality of life (OHRQoL; C-ECOHIS) Post-treatment SDF did not significantly differ from placebo for oral health-related quality of life in children (MD 0.03, 95% CI -0.16 to 0.22; ungraded). Source: Fig 3 (Subnetwork 1); Results 3.2; Abstract · same question in other reviews | MD 0.03 [-0.16, 0.22] | 2 studies · 440 participants | Ungraded |
Oral health-related quality of life Indirect estimate Population: Children with dental caries The indirect estimate found no statistically significant difference in oral health-related quality of life between atraumatic restorative treatment and placebo. Source: Fig 3 · same question in other reviews | MD -0.01 [-0.40, 0.38] | NR | Ungraded |
Oral health-related quality of life Network estimate Population: Children with dental caries The network estimate found no statistically significant difference in oral health-related quality of life between atraumatic restorative treatment and placebo. Source: Fig 3 · same question in other reviews | MD -0.01 [-0.40, 0.38] | NR | Ungraded |
Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART)
Population: Children with dental caries (ages ~2-13 years in the pooled trials)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Oral health-related quality of life (OHRQoL; B-ECOHIS) Post-treatment SDF did not significantly differ from atraumatic restorative treatment for oral health-related quality of life (MD 0.02, 95% CI -0.32 to 0.36; ungraded). Source: Fig 3 (Subnetwork 1); Results 3.2; Abstract · same question in other reviews | MD 0.02 [-0.32, 0.36] | 2 studies · 134 participants | Ungraded |
Oral health-related quality of life Network estimate Population: Children with dental caries The network estimate found no statistically significant difference in oral health-related quality of life between atraumatic restorative treatment and silver diamine fluoride. Source: Fig 3 · same question in other reviews | MD 0.02 [-0.32, 0.36] | 2 studies · 134 participants | Ungraded |
Oral health-related quality of life Direct estimate Population: Children with dental caries The direct estimate found no statistically significant difference in oral health-related quality of life between atraumatic restorative treatment and silver diamine fluoride. Source: Fig 3 · same question in other reviews | MD 0.02 [-0.32, 0.36] | 2 studies · 134 participants | Ungraded |
Placebo vs Silver diamine fluoride
Population: Children with dental caries
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Oral health-related quality of life Direct estimate The direct estimate found no statistically significant difference in oral health-related quality of life between placebo and silver diamine fluoride. Source: Fig 3 · same question in other reviews | MD 0.03 [-0.16, 0.22] | 2 studies · 440 participants | Ungraded |
Oral health-related quality of life (OHRQoL) Post-treatment · Indirect network estimate (no direct trials) Population: Children with dental caries (ages ~2-13 years in the pooled trials) ART and placebo did not differ for oral health-related quality of life, based on an indirect network estimate with no direct trials (MD -0.01, 95% CI -0.40 to 0.38; ungraded). Source: Fig 3 (Subnetwork 1); Results 3.2 · same question in other reviews | MD -0.01 [-0.40, 0.38] | 0 studies | Ungraded |
Oral health-related quality of life Network estimate The network estimate found no statistically significant difference in oral health-related quality of life between placebo and silver diamine fluoride. Source: Fig 3 · same question in other reviews | MD 0.03 [-0.16, 0.22] | 2 studies · 440 participants | Ungraded |
Atraumatic restorative treatment plus fluoride varnish vs Silver diamine fluoride plus fluoride varnish
Population: Children with dental caries
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Oral health-related quality of life Direct estimate The direct estimate found no statistically significant difference in oral health-related quality of life between atraumatic restorative treatment plus fluoride varnish and silver diamine fluoride plus fluoride varnish. Source: Fig 4 · same question in other reviews | MD 0.16 [-0.10, 0.42] | 1 study · 246 participants | Ungraded |
Oral health-related quality of life (OHRQoL; COHIP-SF) Post-treatment Population: Children with dental caries (ages ~2-13 years in the pooled trials) SDF plus fluoride varnish did not significantly differ from ART plus fluoride varnish for oral health-related quality of life (MD 0.16, 95% CI -0.1 to 0.42; ungraded). Source: Fig 4 (Subnetwork 2); Results 3.2; Abstract · same question in other reviews | MD 0.16 [-0.1, 0.42] | 1 study · 246 participants | Ungraded |
Oral health-related quality of life Network estimate The network estimate found no statistically significant difference in oral health-related quality of life between atraumatic restorative treatment plus fluoride varnish and silver diamine fluoride plus fluoride varnish. Source: Fig 4 · same question in other reviews | MD 0.16 [-0.10, 0.42] | 1 study · 246 participants | Ungraded |
AMSTAR 2 appraisal
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | No | No | yes |
| 3Choice of study designs explained | No | Yes | no |
| 4Comprehensive literature searchcritical | Partial Yes | Partial Yes | yes |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | No | No | yes |
| 7List of excluded studies with reasonscritical | No | No | yes |
| 8Included studies described in detail | Yes | Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: Yes · NRSI: Yes | RCT: Yes · NRSI: Yes | yes |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | NRSI: N/A · RCT: Yes | NRSI: N/A · RCT: Yes | yes |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | No | No | yes |
| 14Heterogeneity explained | Yes | N/A | no |
| 15Publication bias investigatedcritical | No | No | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |
Included primary studies 10
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Vollu et al, 2019 Efficacy of 30% silver diamine fluoride compared to atraumatic restorative treatment on dentine caries arrestment in primary molars of… PMID:31279925 | 4 other reviews | Oral health-related quality of life | not extracted yet | not extracted yet |
| Cernigliaro et al, 2019 Caregiver satisfaction with interim silver diamine fluoride applications for their children with caries prior to operating room treatment… PMID:31418870 | this review only | not stated | not extracted yet | not extracted yet |
| Duangthip et al, 2019 Oral health-related quality of life of preschool children receiving silver diamine fluoride therapy: A prospective 6-month study. PMID:30578830 | this review only | not stated | not extracted yet | not extracted yet |
| Hiremath et al, 2020 Acceptability of silver diamine fluoride as interim measure towards untreated dental caries and its impact on ohrqol among children with… PMID:33107447 | this review only | not stated | not extracted yet | not extracted yet |
| Jiang et al, 2019 Effects of restoring SDF-treated and untreated dentine caries lesions on parental satisfaction and oral health related quality of life of… PMID:31325466 | this review only | Oral health-related quality of life | not extracted yet | not extracted yet |
| Jiang et al, 2020 Association between dental conditions, sliver diamine fluoride application, parental satisfaction, and oral health-related quality of life… PMID:32895767 | this review only | Oral health-related quality of life | not extracted yet | not extracted yet |
| Renugalakshmi et al, 2021 Impact of Silver Diamine Fluoride Therapy on Oral Health-related Quality of Life of Uncooperative Preschool Children: A Prospective Study. PMID:33511823 | this review only | not stated | not extracted yet | not extracted yet |
| Rodrigues et al, 2020 Oral Health-Related Quality of Life in Preschool Children After Silver Diamine Fluoride Versus Atraumatic Restorative Treatments. PMID:33087222 | this review only | Oral health-related quality of life | not extracted yet | not extracted yet |
| Ruff et al, 2021 Silver diamine fluoride, atraumatic restorations, and oral health-related quality of life - Results from the <i>CariedAway</i> cluster… DOI:10.1101/2021.04.19.21255478 | this review only | Oral health-related quality of life | not extracted yet | not extracted yet |
| Sihra et al, 2020 The Effectiveness of Silver Diamine Fluoride and Fluoride Varnish in Arresting Caries in Young Children and Associated Oral Health-Related… PMID:32543369 | this review only | not stated | not extracted yet | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match).