Same question across reviews · CL0291
intervention :: Unclassified intervention -> Quality of life
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
53
Questions
108
current versions
GRADE rated
13
Review overlap (CCA)
NR
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy) Participant satisfaction or quality of life · People with temporomandibular disorders (TMD) · Short term (1 month), Mixed TMD Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane | MD -7.56 [-14.50, -0.63] | 2 studies · 75 participants | Ungraded |
Occlusal splint vs Acupuncture Participant satisfaction or quality of life · People with temporomandibular disorders (TMD) · Short term (1 month), Mixed TMD Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane | MD 0.80 [-7.36, 8.96] | 1 study · 30 participants | Ungraded |
Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment Quality of life · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) Interventions for managing oral submucous fibrosis (2024) · Cochrane | The trials did not measure quality of life. | 0 studies | No studies |
Occlusal splint vs Another occlusal splint with a different mechanism of action Participant satisfaction or quality of life · People with temporomandibular disorders (TMD) · Short term (3 months), Mixed TMD Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane | MD -2.29 [-3.13, -1.45] | 1 study · 40 participants | Ungraded |
Occlusal splint vs Behavioural therapy (counselling, CBT, relaxation, self-care management) Participant satisfaction or quality of life · People with temporomandibular disorders (TMD) · Short term (1 month), Mixed TMD Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane | MD -1.42 [-15.78, 12.94] | 2 studies · 73 participants | Ungraded |
Light vibrational forces (LVF) vs Conventional orthodontic appliance treatment (placebo or no adjunct) Oral health-related quality of life (OHRQoL) · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic… (2023) · Cochrane | Katchooi 2018 (unclear risk of bias): light vibrational forces had no statistically significant (P>0.05) effect on OHRQoL when used with orthodontic aligners. | 1 study · 27 participants | Ungraded |
Placebo vs Silver diamine fluoride Oral health-related quality of life · Children with dental caries · Direct estimate Silver diamine fluoride and oral health-related quality of life: A review and network meta-analysis. (2022) | MD 0.03 [-0.16, 0.22] | 2 studies · 440 participants | Ungraded |
Placebo vs Silver diamine fluoride Oral health-related quality of life · Children with dental caries · Network estimate Silver diamine fluoride and oral health-related quality of life: A review and network meta-analysis. (2022) | MD 0.03 [-0.16, 0.22] | 2 studies · 440 participants | Ungraded |
Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs No active intervention/usual care Quality of life indicators · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age · 3-4 months Treatment of periodontitis for glycaemic control in people with diabetes mellitus (2022) · Cochrane | Three studies measured QoL. Vergnes 2018: overall GOHAI adjusted MD 7.0 (95% CI 2.4 to 11.6), 79 participants (better oral health-related QoL); no clear change in general SF-36 QoL. D'Aiuto 2018 ADDQoL better in… | 3 studies | Ungraded |
Hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy vs Conventional therapy Quality of life · People with established (manifest) MRONJ · 6 months Interventions for managing medication‐related osteonecrosis of the jaw (2022) · Cochrane | QoL measured with the Duke Health Profile; only within-group comparisons were provided; no score values, so a between-group analysis was not possible. | 1 study | Ungraded |
Chemotherapy (any regimen; added to, or compared with, locoregional treatment) vs Locoregional treatment and/or an alternative chemotherapy regimen Quality of life · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy (2021) · Cochrane | Quality of life was a planned (protocol) outcome but no included trial provided usable quality-of-life data; the protocol was modified to report only survival/response outcomes. | 0 studies | No studies |
Any orthodontic (non-surgical) treatment to correct posterior crossbite or expand the top teeth vs No treatment or another orthodontic treatment Quality of life · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or… Orthodontic treatment for posterior crossbites (2021) · Cochrane | no estimate extracted | 0 studies | No studies |
Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction Patient-reported outcome measures (PROMs), including quality of life and pain · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC) Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for… (2021) · Cochrane | no estimate extracted | 0 studies | No studies |
Doxycycline + SRP vs Metronidazole + SRP Patient-reported quality of life changes · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clindamycin + SRP vs Metronidazole + SRP Patient-reported quality of life changes · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clindamycin + SRP vs SRP Patient-reported quality of life changes · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Tetracycline + SRP vs SRP Patient-reported quality of life changes · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Doxycycline + SRP vs SRP Patient-reported quality of life changes · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clinical examination with 24-month recall vs Clinical examination with 6-month recall Oral-health-related quality of life (OHIP-14) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders) · 4 years Recall intervals for oral health in primary care patients (2020) · Cochrane | MD -0.24 [-1.55, 1.07] | 1 study · 305 participants | High |
Amoxicillin + metronidazole + SRP vs SRP Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clinical examination with risk-based recall vs Clinical examination with 24-month recall Oral-health-related quality of life (OHIP-14) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders) · 4 years Recall intervals for oral health in primary care patients (2020) · Cochrane | MD -0.37 [-1.69, 0.95] | 1 study · 298 participants | High |
Amoxicillin + clavulanate + SRP vs SRP Patient-reported quality of life changes · Adults with chronic periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clinical examination with 24-month recall vs Clinical examination with 12-month recall Oral-health-related quality of life · Regular-attending primary-care dental patients aged 3, 16 or 18 years at entry (aged up to 20; low caries risk) · 2 years Recall intervals for oral health in primary care patients (2020) · Cochrane | Summary of findings 1 lists 'Oral-health-related quality of life: Not reported' for the 24-month versus 12-month comparison (Wang 1992 did not measure it). | 0 studies | No studies |
Clindamycin + SRP vs Doxycycline + SRP Patient-reported quality of life changes · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Azithromycin + SRP vs SRP Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clinical examination with risk-based recall vs Clinical examination with 6-month recall Oral-health-related quality of life (OHIP-14) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders) · 4 years Recall intervals for oral health in primary care patients (2020) · Cochrane | MD -0.35 [-1.02, 0.32] | 1 study · 1551 participants | High |
Metronidazole + SRP vs SRP Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Surgical removal (extraction) of asymptomatic disease-free impacted wisdom teeth vs Retention (conservative management) of asymptomatic disease-free impacted wisdom teeth Health-related quality of life · Adolescents or adults with asymptomatic disease-free impacted wisdom teeth Surgical removal versus retention for the management of asymptomatic disease‐free impacted wisdom teeth (2020) · Cochrane | Health-related quality of life: Our primary outcome was not assessed in the included studies. | 0 studies | No studies |
Mechanical tongue cleaning (tongue scraper) vs No tongue cleaning Quality of life · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced… Interventions for managing halitosis (2019) · Cochrane | Quality of life was a prespecified secondary outcome. None of the 44 included studies in the review (across all comparisons) reported quality-of-life data (review-wide evidence gap). | 0 studies | No studies |
Personalised one-to-one OHA vs Routine one-to-one OHA Patient-reported changes in knowledge, attitudes and quality of life · Children or adults (fit and healthy, or with a well-defined medical condition) One‐to‐one oral hygiene advice provided in a dental setting for oral health (2018) · Cochrane | Jonsson 2009 (OHQoL-UK oral health-related quality of life) and Ramsay 2018 (dental quality of life, oral hygiene self-efficacy); measured, not synthesised or GRADE-rated. | 2 studies | Ungraded |
Routine scale and polish every 6 months vs Routine scale and polish every 12 months Oral health-related quality of life (OHIP-14) · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental… · 36 months Routine scale and polish for periodontal health in adults (2018) · Cochrane | MD -0.40 [-1.34, 0.54] | 1 study · 786 participants | High |
Orthodontic treatment without extraction of permanent teeth vs Orthodontic treatment involving extraction of permanent teeth Quality of life · Children (80% aged <= 16 years) with a Class II division 2 malocclusion (deep bite and retroclined upper front teeth) Orthodontic treatment for deep bite and retroclined upper front teeth in children (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
Routine scale and polish provided by a dentist vs Routine scale and polish provided by a dental care professional (dental therapist or hygienist) Oral health-related quality of life · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental… Routine scale and polish for periodontal health in adults (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
Wax (fluid wax), two stage-two step selective pressure final impression vs Polysulfide rubber (elastomer) Participant-reported oral health-related quality of life (OHIP-EDENT) · Completely edentulous people Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane | Not measured | 0 studies | No studies |
Biofunctional Prosthetic System (BPS): closed-mouth two stage-two step final impression with addition silicone elastomer vs Conventional complete denture technique (CCD): open-mouth two stage-two step conventional technique using elastomer Participant-reported oral health-related quality of life (OHIP-EDENT) · Completely edentulous people · 3 months Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane | OHIP-EDENT median scores: BPS 34.5; CCD 35.8. No clear difference between groups | 1 study · 10 participants | Very low |
14% / HP strips vs Placebo Oral health-related quality of life · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline… Home‐based chemically‐induced whitening (bleaching) of teeth in adults (2018) · Cochrane | No significant impact of tooth whitening on OHRQoL (Bruhn 2012; Wong 2004) | 2 studies | Ungraded |
Autologous platelet concentrates (APC) + guided tissue regeneration (GTR) vs GTR (guided tissue regeneration) alone Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane | No quantitative analysis regarding patients' quality of life was possible (no data). | 0 studies | No studies |
Ball (stud) attachment system vs Bar attachment system Patient satisfaction / quality of life (validated measure) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures) Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane | Only Walton 2002 assessed patient satisfaction but reported narrative results and failed to provide any usable numbers. Quality of life as assessed by a validated measure was not recorded in any of the trials. | 1 study | Ungraded |
Altered-cast impression technique (ACIP), polyether vs One-piece cast technique (OPC), polyether Participant-reported oral health-related quality of life · Partially edentulous people requiring a tooth- and tissue-supported (distal-extension) removable partial denture Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane | Not measured | 0 studies | No studies |
Autologous platelet concentrates (APC) + enamel matrix derivative (EMD) vs EMD (enamel matrix derivative) alone Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane | No quantitative analysis regarding patients' quality of life was possible (no data). | 0 studies | No studies |
Single-stage alginate impression (simplified method) vs Two stage-two step zinc-oxide eugenol (ZoE) traditional method Participant-reported oral health-related quality of life (OHIP-EDENT) · Completely edentulous people · 6 months Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane | MD 0.5 [-2.67, 3.67] | 1 study · 39 participants | Very low |
Alginate (two stage-two step final/wash impression) vs Silicone elastomer (two stage-two step) Participant-reported oral health-related quality of life (OHIP-EDENT; lower score = better) · Completely edentulous people · 2 weeks Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane | MD 7.20 [2.71, 11.69] | 1 study · 144 participants | Low |
Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft) Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane | No quantitative analysis regarding patients' quality of life was possible (no data). | 0 studies | No studies |
Orthodontic treatment without extraction of permanent teeth (removable, fixed, or functional braces, or headgear) vs No treatment (or delayed treatment) Quality of life · Children (80% aged <= 16 years) with a Class II division 2 malocclusion (deep bite and retroclined upper front teeth) Orthodontic treatment for deep bite and retroclined upper front teeth in children (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
Ball (stud) attachment system vs Telescopic attachment system Patient satisfaction / quality of life (validated measure) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures) Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane | Cepa 2017 assessed patient satisfaction but did not use validated measures and we could not use the data. Quality of life as assessed by a validated measure was not recorded. | 1 study | Ungraded |
Single-stage alginate impression (simplified method) vs Two stage-two step elastomer (silicone, polysulfide, or polyether) conventional method Participant-reported oral health-related quality of life (OHIP-EDENT) · Completely edentulous people · 1 month Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane | MD 0.05 [-2.37, 2.47] | 2 studies · 98 participants | Very low |
Enhanced one-to-one OHA vs One-to-one OHA (standard) Patient-reported changes in knowledge, attitudes and quality of life · Children or adults (fit and healthy, or with a well-defined medical condition) One‐to‐one oral hygiene advice provided in a dental setting for oral health (2018) · Cochrane | Hoogstraten 1983 (dental knowledge, attitude, behaviour, fear), Munster Halvari 2012 (multiple psychological measures: autonomy, motivation, perceived competence), Tedesco 1992 (theory of reasoned action variables);… | 3 studies | Ungraded |
Ball (stud) attachment system vs Magnetic attachment system Patient satisfaction / quality of life (validated measure) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures) Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane | Two trials (Cune 2010; Naert 1999) reported patient satisfaction. However, we could not use any data from these studies. Quality of life as assessed by a validated measure was not recorded in any of the trials. | 2 studies | Ungraded |
Autologous platelet concentrates (APC) + open flap debridement (OFD) vs OFD (open flap debridement) alone Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane | No quantitative analysis regarding patients' quality of life was possible (no data). | 0 studies | No studies |
Planned, regular routine scale and polish (6-monthly; 12-monthly parallel) vs No scheduled scale and polish treatment Oral health-related quality of life (OHIP-14) · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental… · 36 months, 6-monthly (12-monthly parallel) Routine scale and polish for periodontal health in adults (2018) · Cochrane | MD -0.30 [-1.24, 0.64] | 1 study · 795 participants | High |