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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
108 questions in 53 reviews · cluster CL0291
current versionsNo studies 59 · 54.6%Ungraded 36 · 33.3%Very low 7 · 6.5%Low 1 · 0.9%Moderate 0 · 0%High 5 · 4.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy) Participant satisfaction or quality of life · People with temporomandibular disorders (TMD) · Short term (1 month), Mixed TMD Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane | MD -7.56 [-14.50, -0.63] | 2 studies · 75 participants | Ungraded |
Occlusal splint vs Acupuncture Participant satisfaction or quality of life · People with temporomandibular disorders (TMD) · Short term (1 month), Mixed TMD Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane | MD 0.80 [-7.36, 8.96] | 1 study · 30 participants | Ungraded |
Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment Quality of life · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) Interventions for managing oral submucous fibrosis (2024) · Cochrane | The trials did not measure quality of life. | 0 studies | No studies |
Occlusal splint vs Another occlusal splint with a different mechanism of action Participant satisfaction or quality of life · People with temporomandibular disorders (TMD) · Short term (3 months), Mixed TMD Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane | MD -2.29 [-3.13, -1.45] | 1 study · 40 participants | Ungraded |
Occlusal splint vs Behavioural therapy (counselling, CBT, relaxation, self-care management) Participant satisfaction or quality of life · People with temporomandibular disorders (TMD) · Short term (1 month), Mixed TMD Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane | MD -1.42 [-15.78, 12.94] | 2 studies · 73 participants | Ungraded |
Light vibrational forces (LVF) vs Conventional orthodontic appliance treatment (placebo or no adjunct) Oral health-related quality of life (OHRQoL) · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic… (2023) · Cochrane | Katchooi 2018 (unclear risk of bias): light vibrational forces had no statistically significant (P>0.05) effect on OHRQoL when used with orthodontic aligners. | 1 study · 27 participants | Ungraded |
Placebo vs Silver diamine fluoride Oral health-related quality of life · Children with dental caries · Direct estimate Silver diamine fluoride and oral health-related quality of life: A review and network meta-analysis. (2022) | MD 0.03 [-0.16, 0.22] | 2 studies · 440 participants | Ungraded |
Placebo vs Silver diamine fluoride Oral health-related quality of life · Children with dental caries · Network estimate Silver diamine fluoride and oral health-related quality of life: A review and network meta-analysis. (2022) | MD 0.03 [-0.16, 0.22] | 2 studies · 440 participants | Ungraded |
Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs No active intervention/usual care Quality of life indicators · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age · 3-4 months Treatment of periodontitis for glycaemic control in people with diabetes mellitus (2022) · Cochrane | Three studies measured QoL. Vergnes 2018: overall GOHAI adjusted MD 7.0 (95% CI 2.4 to 11.6), 79 participants (better oral health-related QoL); no clear change in general SF-36 QoL. D'Aiuto 2018 ADDQoL better in… | 3 studies | Ungraded |
Hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy vs Conventional therapy Quality of life · People with established (manifest) MRONJ · 6 months Interventions for managing medication‐related osteonecrosis of the jaw (2022) · Cochrane | QoL measured with the Duke Health Profile; only within-group comparisons were provided; no score values, so a between-group analysis was not possible. | 1 study | Ungraded |
Chemotherapy (any regimen; added to, or compared with, locoregional treatment) vs Locoregional treatment and/or an alternative chemotherapy regimen Quality of life · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy (2021) · Cochrane | Quality of life was a planned (protocol) outcome but no included trial provided usable quality-of-life data; the protocol was modified to report only survival/response outcomes. | 0 studies | No studies |
Any orthodontic (non-surgical) treatment to correct posterior crossbite or expand the top teeth vs No treatment or another orthodontic treatment Quality of life · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or… Orthodontic treatment for posterior crossbites (2021) · Cochrane | no estimate extracted | 0 studies | No studies |
Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction Patient-reported outcome measures (PROMs), including quality of life and pain · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC) Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for… (2021) · Cochrane | no estimate extracted | 0 studies | No studies |
Doxycycline + SRP vs Metronidazole + SRP Patient-reported quality of life changes · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clindamycin + SRP vs Metronidazole + SRP Patient-reported quality of life changes · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clindamycin + SRP vs SRP Patient-reported quality of life changes · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Tetracycline + SRP vs SRP Patient-reported quality of life changes · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Doxycycline + SRP vs SRP Patient-reported quality of life changes · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clinical examination with 24-month recall vs Clinical examination with 6-month recall Oral-health-related quality of life (OHIP-14) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders) · 4 years Recall intervals for oral health in primary care patients (2020) · Cochrane | MD -0.24 [-1.55, 1.07] | 1 study · 305 participants | High |
Amoxicillin + metronidazole + SRP vs SRP Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clinical examination with risk-based recall vs Clinical examination with 24-month recall Oral-health-related quality of life (OHIP-14) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders) · 4 years Recall intervals for oral health in primary care patients (2020) · Cochrane | MD -0.37 [-1.69, 0.95] | 1 study · 298 participants | High |
Amoxicillin + clavulanate + SRP vs SRP Patient-reported quality of life changes · Adults with chronic periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clinical examination with 24-month recall vs Clinical examination with 12-month recall Oral-health-related quality of life · Regular-attending primary-care dental patients aged 3, 16 or 18 years at entry (aged up to 20; low caries risk) · 2 years Recall intervals for oral health in primary care patients (2020) · Cochrane | Summary of findings 1 lists 'Oral-health-related quality of life: Not reported' for the 24-month versus 12-month comparison (Wang 1992 did not measure it). | 0 studies | No studies |
Clindamycin + SRP vs Doxycycline + SRP Patient-reported quality of life changes · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Azithromycin + SRP vs SRP Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clinical examination with risk-based recall vs Clinical examination with 6-month recall Oral-health-related quality of life (OHIP-14) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders) · 4 years Recall intervals for oral health in primary care patients (2020) · Cochrane | MD -0.35 [-1.02, 0.32] | 1 study · 1551 participants | High |
Metronidazole + SRP vs SRP Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Surgical removal (extraction) of asymptomatic disease-free impacted wisdom teeth vs Retention (conservative management) of asymptomatic disease-free impacted wisdom teeth Health-related quality of life · Adolescents or adults with asymptomatic disease-free impacted wisdom teeth Surgical removal versus retention for the management of asymptomatic disease‐free impacted wisdom teeth (2020) · Cochrane | Health-related quality of life: Our primary outcome was not assessed in the included studies. | 0 studies | No studies |
Mechanical tongue cleaning (tongue scraper) vs No tongue cleaning Quality of life · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced… Interventions for managing halitosis (2019) · Cochrane | Quality of life was a prespecified secondary outcome. None of the 44 included studies in the review (across all comparisons) reported quality-of-life data (review-wide evidence gap). | 0 studies | No studies |
Personalised one-to-one OHA vs Routine one-to-one OHA Patient-reported changes in knowledge, attitudes and quality of life · Children or adults (fit and healthy, or with a well-defined medical condition) One‐to‐one oral hygiene advice provided in a dental setting for oral health (2018) · Cochrane | Jonsson 2009 (OHQoL-UK oral health-related quality of life) and Ramsay 2018 (dental quality of life, oral hygiene self-efficacy); measured, not synthesised or GRADE-rated. | 2 studies | Ungraded |
Routine scale and polish every 6 months vs Routine scale and polish every 12 months Oral health-related quality of life (OHIP-14) · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental… · 36 months Routine scale and polish for periodontal health in adults (2018) · Cochrane | MD -0.40 [-1.34, 0.54] | 1 study · 786 participants | High |
Orthodontic treatment without extraction of permanent teeth vs Orthodontic treatment involving extraction of permanent teeth Quality of life · Children (80% aged <= 16 years) with a Class II division 2 malocclusion (deep bite and retroclined upper front teeth) Orthodontic treatment for deep bite and retroclined upper front teeth in children (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
Routine scale and polish provided by a dentist vs Routine scale and polish provided by a dental care professional (dental therapist or hygienist) Oral health-related quality of life · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental… Routine scale and polish for periodontal health in adults (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
Wax (fluid wax), two stage-two step selective pressure final impression vs Polysulfide rubber (elastomer) Participant-reported oral health-related quality of life (OHIP-EDENT) · Completely edentulous people Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane | Not measured | 0 studies | No studies |
Biofunctional Prosthetic System (BPS): closed-mouth two stage-two step final impression with addition silicone elastomer vs Conventional complete denture technique (CCD): open-mouth two stage-two step conventional technique using elastomer Participant-reported oral health-related quality of life (OHIP-EDENT) · Completely edentulous people · 3 months Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane | OHIP-EDENT median scores: BPS 34.5; CCD 35.8. No clear difference between groups | 1 study · 10 participants | Very low |
14% / HP strips vs Placebo Oral health-related quality of life · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline… Home‐based chemically‐induced whitening (bleaching) of teeth in adults (2018) · Cochrane | No significant impact of tooth whitening on OHRQoL (Bruhn 2012; Wong 2004) | 2 studies | Ungraded |
Autologous platelet concentrates (APC) + guided tissue regeneration (GTR) vs GTR (guided tissue regeneration) alone Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane | No quantitative analysis regarding patients' quality of life was possible (no data). | 0 studies | No studies |
Ball (stud) attachment system vs Bar attachment system Patient satisfaction / quality of life (validated measure) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures) Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane | Only Walton 2002 assessed patient satisfaction but reported narrative results and failed to provide any usable numbers. Quality of life as assessed by a validated measure was not recorded in any of the trials. | 1 study | Ungraded |
Altered-cast impression technique (ACIP), polyether vs One-piece cast technique (OPC), polyether Participant-reported oral health-related quality of life · Partially edentulous people requiring a tooth- and tissue-supported (distal-extension) removable partial denture Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane | Not measured | 0 studies | No studies |
Autologous platelet concentrates (APC) + enamel matrix derivative (EMD) vs EMD (enamel matrix derivative) alone Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane | No quantitative analysis regarding patients' quality of life was possible (no data). | 0 studies | No studies |
Single-stage alginate impression (simplified method) vs Two stage-two step zinc-oxide eugenol (ZoE) traditional method Participant-reported oral health-related quality of life (OHIP-EDENT) · Completely edentulous people · 6 months Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane | MD 0.5 [-2.67, 3.67] | 1 study · 39 participants | Very low |
Alginate (two stage-two step final/wash impression) vs Silicone elastomer (two stage-two step) Participant-reported oral health-related quality of life (OHIP-EDENT; lower score = better) · Completely edentulous people · 2 weeks Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane | MD 7.20 [2.71, 11.69] | 1 study · 144 participants | Low |
Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft) Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane | No quantitative analysis regarding patients' quality of life was possible (no data). | 0 studies | No studies |
Orthodontic treatment without extraction of permanent teeth (removable, fixed, or functional braces, or headgear) vs No treatment (or delayed treatment) Quality of life · Children (80% aged <= 16 years) with a Class II division 2 malocclusion (deep bite and retroclined upper front teeth) Orthodontic treatment for deep bite and retroclined upper front teeth in children (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
Ball (stud) attachment system vs Telescopic attachment system Patient satisfaction / quality of life (validated measure) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures) Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane | Cepa 2017 assessed patient satisfaction but did not use validated measures and we could not use the data. Quality of life as assessed by a validated measure was not recorded. | 1 study | Ungraded |
Single-stage alginate impression (simplified method) vs Two stage-two step elastomer (silicone, polysulfide, or polyether) conventional method Participant-reported oral health-related quality of life (OHIP-EDENT) · Completely edentulous people · 1 month Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane | MD 0.05 [-2.37, 2.47] | 2 studies · 98 participants | Very low |
Enhanced one-to-one OHA vs One-to-one OHA (standard) Patient-reported changes in knowledge, attitudes and quality of life · Children or adults (fit and healthy, or with a well-defined medical condition) One‐to‐one oral hygiene advice provided in a dental setting for oral health (2018) · Cochrane | Hoogstraten 1983 (dental knowledge, attitude, behaviour, fear), Munster Halvari 2012 (multiple psychological measures: autonomy, motivation, perceived competence), Tedesco 1992 (theory of reasoned action variables);… | 3 studies | Ungraded |
Ball (stud) attachment system vs Magnetic attachment system Patient satisfaction / quality of life (validated measure) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures) Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane | Two trials (Cune 2010; Naert 1999) reported patient satisfaction. However, we could not use any data from these studies. Quality of life as assessed by a validated measure was not recorded in any of the trials. | 2 studies | Ungraded |
Autologous platelet concentrates (APC) + open flap debridement (OFD) vs OFD (open flap debridement) alone Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane | No quantitative analysis regarding patients' quality of life was possible (no data). | 0 studies | No studies |
Planned, regular routine scale and polish (6-monthly; 12-monthly parallel) vs No scheduled scale and polish treatment Oral health-related quality of life (OHIP-14) · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental… · 36 months, 6-monthly (12-monthly parallel) Routine scale and polish for periodontal health in adults (2018) · Cochrane | MD -0.30 [-1.24, 0.64] | 1 study · 795 participants | High |