Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

460 questions · 464 findings · 50 reviews · Pregnancy and Childbirth

No studies found 103 · 22.2%GRADE not reported 61 · 13.1%Very low 120 · 25.9%Low 112 · 24.1%Moderate 59 · 12.7%High 9 · 1.9%

Planned early birth vs expectant management

Maternal infectious morbidity (chorioamnionitis and/or endometritis) · women with prelabour rupture of membranes at term (37 weeks' gestation or later)

Planned early birth may leads to lower maternal infectious morbidity (chorioamnionitis and/or endometritis) compared with expectant management (low certainty).

1 finding from 1 review

Misoprostol vs surgery

Women's views/acceptability of method · incomplete miscarriage

Misoprostol showed no clear difference in women's views/acceptability of method compared with surgery (moderate certainty).

1 finding from 1 review

Amnioinfusion vs no amnioinfusion

Postpartum endometritis · pregnant women with confirmed or suspected chorioamnionitis

Amnioinfusion showed no clear difference in postpartum endometritis compared with no amnioinfusion (low certainty).

1 finding from 1 review

Prophylactic antibiotics vs placebo

Puerperal sepsis/postpartum endometritis · women in the second or third trimester of pregnancy before labour and delivery

Prophylactic antibiotics probably leads to lower puerperal sepsis/postpartum endometritis compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo or no antibiotic

Maternal infectious morbidity (chorioamnionitis and/or endometritis) ‐ Early induction of labour · pregnant women with prelabour rupture of membranes at or near term

Any antibiotic showed no clear difference in maternal infectious morbidity (chorioamnionitis and/or endometritis)… compared with placebo or no antibiotic (subgrouped by timing of induction of labour) (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no antibiotic

Maternal infectious morbidity (chorioamnionitis and/or endometritis) ‐ Late induction of labour · pregnant women with prelabour rupture of membranes at or near term

It is very uncertain whether any antibiotic changes maternal infectious morbidity (chorioamnionitis and/or endometritis)… compared with placebo or no antibiotic (subgrouped by timing of induction of labour) (very low certainty).

1 finding from 1 review

Chlorhexidine vaginal wash vs placebo

Postpartum endometritis Clinical findings · Pregnant women with a gestational age greater than 28 weeks, considered to be in labour receiving chlorhexidine vaginal douching during…

Chlorhexidine vaginal wash showed no clear difference in postpartum endometritis Clinical findings compared with placebo (moderate certainty).

1 finding from 1 review