Cochrane · systematic review · CD012137
Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity
Bonet, M, Ota, E, Chibueze, CE, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 28.6%Very low 4 · 57.1%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Routine antibiotic prophylaxis compared to no treatment or placebo for preventing infections in women who had normal vaginal births
Population: Women who had normal vaginal births
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of severe maternal infectious morbidity (including septicaemia, septic shock, laparotomy/hysterectomy for infection, maternal intensive care unit admission, or organ failure) Routine antibiotic prophylaxis vs no treatment or placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Endometritis Routine antibiotic prophylaxis vs no treatment or placebo | RR 0.28 [0.09, 0.83] | 2 studies · 1364 participants | Very low Downgraded: imprecision |
Urinary tract infection Routine antibiotic prophylaxis vs no treatment or placebo | RR 0.25 [0.05, 1.19] | 2 studies · 1706 participants | Low |
Wound infection (episiotomy dehiscence) Routine antibiotic prophylaxis vs no treatment or placebo | RR 0.78 [0.31, 1.96] | 2 studies · 1364 participants | Very low Downgraded: imprecision |
Adverse effects of antibiotics (skin rash) Routine antibiotic prophylaxis vs no treatment or placebo | RR 3.03 [0.32, 28.95] | 2 studies · 1706 participants | Very low Downgraded: imprecision |
Length of maternal hospital stay Routine antibiotic prophylaxis vs no treatment or placebo | no estimate extracted | 1 study · 1291 participants | Very low Downgraded: imprecision |
Individual antimicrobial resistance Routine antibiotic prophylaxis vs no treatment or placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |