Cochrane · systematic review · CD002250

Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity

Thinkhamrop, J, Hofmeyr, GJ, Adetoro, O, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library

Pregnancy and Childbirth2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 1 · 16.7%Very low 1 · 16.7%Low 2 · 33.3%Moderate 1 · 16.7%High 1 · 16.7%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Prophylactic antibiotics versus placebo for preventing infectious morbidity and mortality

Population: women in the second or third trimester of pregnancy before labour and delivery

6 questions

Outcome	Effect	Evidence	Status / GRADE
Preterm prelabour rupture of membranes Prophylactic antibiotics vs placebo	RR 0.31 [0.06, 1.49]	1 study · 229 participants	Low Downgraded: imprecision
Prelabour rupture of membranes Prophylactic antibiotics vs placebo	RR 0.34 [0.15, 0.78]	1 study · 229 participants	Low Downgraded: imprecision
Preterm delivery Prophylactic antibiotics vs placebo	RR 0.88 [0.72, 1.09]	6 studies · 3663 participants	High
Chorioamnionitis Prophylactic antibiotics vs placebo	RR 0.62 [0.1, 3.62]	1 study · 229 participants	Very low Downgraded: imprecision
Puerperal sepsis/postpartum endometritis Prophylactic antibiotics vs placebo	RR 0.53 [0.35, 0.82]	3 studies · 627 participants	Moderate Downgraded: imprecision
Intrapartum fever needing treatment with antibiotics Prophylactic antibiotics vs placebo	no estimate extracted	0 studies · 0 participants	Ungraded