Cochrane · systematic review · CD002250
Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity
Thinkhamrop, J, Hofmeyr, GJ, Adetoro, O, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 16.7%Very low 1 · 16.7%Low 2 · 33.3%Moderate 1 · 16.7%High 1 · 16.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyProphylactic antibiotics versus placebo for preventing infectious morbidity and mortality
Population: women in the second or third trimester of pregnancy before labour and delivery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Preterm prelabour rupture of membranes Prophylactic antibiotics vs placebo | RR 0.31 [0.06, 1.49] | 1 study · 229 participants | Low Downgraded: imprecision |
Prelabour rupture of membranes Prophylactic antibiotics vs placebo | RR 0.34 [0.15, 0.78] | 1 study · 229 participants | Low Downgraded: imprecision |
Preterm delivery Prophylactic antibiotics vs placebo | RR 0.88 [0.72, 1.09] | 6 studies · 3663 participants | High |
Chorioamnionitis Prophylactic antibiotics vs placebo | RR 0.62 [0.1, 3.62] | 1 study · 229 participants | Very low Downgraded: imprecision |
Puerperal sepsis/postpartum endometritis Prophylactic antibiotics vs placebo | RR 0.53 [0.35, 0.82] | 3 studies · 627 participants | Moderate Downgraded: imprecision |
Intrapartum fever needing treatment with antibiotics Prophylactic antibiotics vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Prophylactic antibiotics versus placebo for preventing infectious morbidity and mortality
Population: women in the second or third trimester of pregnancy before labour and delivery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Preterm prelabour rupture of membranes Prophylactic antibiotics vs placebo | RR 0.31 [0.06, 1.49] | 1 study · 229 participants | Low Downgraded: imprecision |
Prelabour rupture of membranes Prophylactic antibiotics vs placebo | RR 0.34 [0.15, 0.78] | 1 study · 229 participants | Low Downgraded: imprecision |
Preterm delivery Prophylactic antibiotics vs placebo | RR 0.85 [0.64, 1.14] | 5 studies · 1480 participants | Low Downgraded: imprecision |
Chorioamnionitis Prophylactic antibiotics vs placebo | RR 0.62 [0.1, 3.62] | 1 study · 229 participants | Very low Downgraded: imprecision |
Puerperal sepsis/postpartum endometritis Prophylactic antibiotics vs placebo | RR 0.53 [0.35, 0.82] | 3 studies · 627 participants | Moderate Downgraded: imprecision |
Intrapartum fever needing treatment with antibiotics Prophylactic antibiotics vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |