Cochrane · systematic review · CD001807
Antibiotics for prelabour rupture of membranes at or near term
Wojcieszek, AM, Stock, OM, Flenady, V · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 20%Very low 3 · 30%Low 5 · 50%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Any antibiotic compared with placebo or no antibiotic (subgrouped by timing of induction of labour) for prelabour rupture of membranes at or near term
Population: pregnant women with prelabour rupture of membranes at or near term
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Probable early‐onset neonatal sepsis ‐ Early induction of labour Any antibiotic vs placebo or no antibiotic (subgrouped by timing of induction of labour) | RR 1.47 [0.8, 2.7] | 1 study · 1640 participants | Low Downgraded: imprecision |
Probable early‐onset neonatal sepsis ‐ Late induction of labour Any antibiotic vs placebo or no antibiotic (subgrouped by timing of induction of labour) | RR 0.14 [0.02, 1.13] | 2 studies · 838 participants | Very low Downgraded: risk of bias, imprecision |
Definite early‐onset neonatal sepsis ‐ Early induction of labour Any antibiotic vs placebo or no antibiotic (subgrouped by timing of induction of labour) | RR 1.29 [0.48, 3.44] | 1 study · 1640 participants | Low Downgraded: imprecision |
Definite early‐onset neonatal sepsis ‐ Late induction of labour Any antibiotic vs placebo or no antibiotic (subgrouped by timing of induction of labour) | RR 0.16 [0.02, 1.34] | 2 studies · 838 participants | Very low Downgraded: risk of bias, imprecision |
Maternal infectious morbidity (chorioamnionitis and/or endometritis) ‐ Early induction of labour Any antibiotic vs placebo or no antibiotic (subgrouped by timing of induction of labour) | RR 1.15 [0.64, 2.08] | 1 study · 1640 participants | Low Downgraded: imprecision |
Maternal infectious morbidity (chorioamnionitis and/or endometritis) ‐ Late induction of labour Any antibiotic vs placebo or no antibiotic (subgrouped by timing of induction of labour) | RR 0.34 [0.08, 1.47] | 2 studies · 838 participants | Very low Downgraded: risk of bias, imprecision |
Any antibiotic compared with placebo or no antibiotic for prelabour rupture of membranes at or near term
Population: pregnant women with prelabour rupture of membranes at or near term
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Stillbirth Any antibiotic vs placebo or no antibiotic | RR 3 [0.61, 14.82] | 3 studies · 1906 participants | Low Downgraded: imprecision |
Perinatal mortality Any antibiotic vs placebo or no antibiotic | RR 1.98 [0.6, 6.55] | 4 studies · 2639 participants | Low Downgraded: imprecision |
Neonatal mortality Any antibiotic vs placebo or no antibiotic | no estimate extracted | 3 studies · 1906 participants | Ungraded |
Serious maternal outcome Any antibiotic vs placebo or no antibiotic | no estimate extracted | 3 studies · 1906 participants | Ungraded |