evidencegaps
Cochrane · systematic review · CD004070

Vaginal chlorhexidine during labour for preventing maternal and neonatal infections (excluding Group B Streptococcal and HIV)

Lumbiganon, P, Thinkhamrop, J, Thinkhamrop, B, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library

Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 50%Moderate 2 · 50%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Chlorhexidine vaginal wash versus placebo for preventing maternal and neonatal infections (excluding Group B Streptococcal and HIV)

Population: Pregnant women with a gestational age greater than 28 weeks, considered to be in labour receiving chlorhexidine vaginal douching during labour versus placebo to prevent maternal and neonatal infections (excluding Group B Streptococcal and HIV).
4 questions
OutcomeEffectEvidenceStatus / GRADE
Chorioamnionitis Clinical findings
Chlorhexidine vaginal wash vs placebo
RR 1.1 [0.86, 1.42]3 studies · 3012 participantsModerate
Downgraded: imprecision
Postpartum endometritis Clinical findings
Chlorhexidine vaginal wash vs placebo
RR 0.83 [0.61, 1.13]3 studies · 3012 participantsModerate
Downgraded: imprecision
Neonatal sepsis Clinical findings
Chlorhexidine vaginal wash vs placebo
RR 0.75 [0.17, 3.35]3 studies · 2987 participantsLow
Downgraded: imprecision
Blood culture confirming neonatal sepsis Clinical findings and confirmation by laboratory
Chlorhexidine vaginal wash vs placebo
RR 0.75 [0.17, 3.35]2 studies · 2077 participantsLow
Downgraded: imprecision