Cochrane · systematic review · CD002253
Medical treatment for early fetal death (less than 24 weeks)
Lemmers, M, Verschoor, MAC, Kim, BV, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
13
No studies
1
Included studies
NR
No studies 1 · 7.1%Ungraded 0 · 0%Very low 2 · 14.3%Low 11 · 78.6%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Vaginal misoprostol compared to placebo for early fetal death (less than 24 weeks)
Population: early fetal death (less than 24 weeks)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete miscarriage Vaginal misoprostol vs placebo | RR 4.23 [3.01, 5.94] | 5 studies · 305 participants | Low Downgraded: indirectness |
Pelvic infection Vaginal misoprostol vs placebo | no estimate extracted | NR | No studies |
Nausea Vaginal misoprostol vs placebo | RR 1.38 [0.43, 4.4] | 2 studies · 88 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Diarrhoea Vaginal misoprostol vs placebo | RR 2.21 [0.35, 14.06] | 2 studies · 88 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Blood loss: haemoglobin difference > 10 g/L Vaginal misoprostol vs placebo | RR 1.25 [0.38, 4.12] | 1 study · 50 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Pain (opiate use) Vaginal misoprostol vs placebo | RR 5 [0.25, 101.11] | 1 study · 84 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Woman’s satisfaction/acceptability of method Vaginal misoprostol vs placebo | RR 1.17 [0.83, 1.64] | 1 study · 32 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Vaginal misoprostol compared to surgical evacuation of uterus for early fetal death (less than 24 weeks)
Population: early fetal death (less than 24 weeks)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete miscarriage Vaginal misoprostol vs surgical evacuation of uterus | RR 0.4 [0.32, 0.5] | 6 studies · 943 participants | Low Downgraded: risk of bias, imprecision |
Pelvic infection Vaginal misoprostol vs surgical evacuation of uterus | RR 0.73 [0.39, 1.37] | 1 study · 618 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Nausea Vaginal misoprostol vs surgical evacuation of uterus | RR 21.85 [1.31, 364.37] | 1 study · 154 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Diarrhoea Vaginal misoprostol vs surgical evacuation of uterus | RR 40.85 [2.52, 662.57] | 1 study · 154 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Blood loss: post‐treatment haematocrit (%) Vaginal misoprostol vs surgical evacuation of uterus | no estimate extracted | 1 study · 50 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Pain relief Vaginal misoprostol vs surgical evacuation of uterus | RR 1.42 | 1 study · 154 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Woman’s satisfaction/acceptability of method Vaginal misoprostol vs surgical evacuation of uterus | RR 0.67 [0.4, 1.11] | 1 study · 45 participants | Low Downgraded: risk of bias, imprecision, inconsistency |