Search review questions

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Adjusted for age/sex

Dental caries prevalence · General Pakistani population (all ages and both sexes; predominantly children and adolescents) · Dentition: mixed

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Multivariable-adjusted

Molar-incisor hypomineralization prevalence · School children aged 8-12 years in Dubai public schools · Overall

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · Caries detection level

Mean dmft · Preschool children in Abu Dhabi nurseries · Emirati children

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious… · 6-60 months, Deep lesions, permanent dentition

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

Overall survival, induction platinum + 5-fluorouracil prior to surgery vs surgery alone · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Sensitivity for detection of enamel caries · Asymptomatic children or adults presenting for clinical examination (in vivo studies), or extracted teeth of children… · Up to 3 months between index test and reference standard (in vivo studies), Occlusal surface

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · Caries detection level

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious… · 24-36 months, Deep lesions, primary dentition

Sensitivity for detection of enamel/early caries · Children or adults presenting asymptomatically or suspected of having enamel caries (clinical/in vivo studies);… · Up to 3 months between index test and reference standard (in vivo; in vitro no limit if stored appropriately)

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Sensitivity analysis: low risk of bias for index test

Optical/esthetic improvement (visual-tactile assessment) · Patients with post-orthodontic white spot lesions (WSL) · 4 weeks to 6 months, Visual analog scale (Senestraro et al. 2013)

Water samples with fluoride concentration below the acceptable range · Region: South Brazil

Overall survival, chemotherapy regimen A vs regimen B · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Outcome NR · Children/adolescents/adults or extracted teeth; target condition = non-cavitated enamel caries on SMOOTH tooth surfaces. · Up to 3 months between index test and reference standard (in vivo studies)

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious… · 30-60 months, Cavitated (not deep) lesions, primary dentition

Mean DMFT (decayed, missing, filled permanent teeth) · Individuals with permanent dentition in East Africa · Tanzania

Probing depth (PD) · Adults (general and hospital populations assessed in case-control studies) · Asia (Elimelech 2015, Leung 2011, Mayer 2013)

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Reference standard: excavation (non-CBCT)

Specificity · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or… · Up to 3 months between index test and reference standard (in vivo studies), Permanent dentition

Full-mouth plaque score (FMPS) · Adolescents/teenagers undergoing orthodontic treatment · 12 months, Adolescents

Mean dmft · Preschoolers (AlKhayat, Dubai)

Dental caries prevalence · Kenya

Restoration failure rate · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6… · Follow-up >= 3 years, Parallel-group and split-mouth trials combined

Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Ethnicity: Caucasian

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

Gingival index (GI) · Adolescents/teenagers undergoing orthodontic treatment · 18 months, Adolescents

Diagnostic accuracy for proximal caries detection (caries detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo) · Caries detection level

Dental caries prevalence · Pakistani population of any sex or age · 2009 to 2020, Fixed-effects model

Prevalence of periodontitis · Adults (general and hospital populations assessed in case-control studies)

Diagnostic accuracy for proximal caries detection (1/3 dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · 1/3 dentin detection level

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

Secondary caries · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6… · Follow-up >= 3 years, Parallel-group and split-mouth trials combined

Incidence of new white spot lesions by visual-tactile assessment · Patients receiving comprehensive fixed orthodontic treatment · 12 to 24 months, Overall

Care index · Emirati preschool children in Ras Al Khaimah nurseries · Overall

Daily tooth brushing · School-aged children in Sharjah · Females

S. mutans presence (CFU > 10^5) · Adults undergoing orthodontic treatment · 3 months, Adults

Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Dentition: Permanent tooth caries

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · Caries detection level

Outcome NR · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Dentine-caries (D3) prevalence high >=35% or unreported (non-CBCT)

Dental caries prevalence · General population in Ethiopia (all ages, age range 6-100 years) · Addis Ababa

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Analogue and digital combined (non-CBCT); 97 datasets

Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Overall

Dental caries prevalence · General Pakistani population (all ages and both sexes; predominantly children and adolescents) · City: Islamabad and Rawalpindi (combined)

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious… · 24 months, Cavitated but not deep lesions, primary dentition