Search review questions

Dental caries (prevalence) · Adults · Severe periodontitis

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Region: Middle East

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), Asian ethnicity

Aesthetics · Children and adults (with or without carious lesions)

Secondary prevention of caries · Children and adults (with or without carious lesions) · 18 months, Primary dentition

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (C vs A)

Decayed, missing, filled surfaces (DMFS) · Periodontal disease severity (CDC-AAP); single study (Robert 2019); adjusted

Streptococcus viridans count (CFU/mL) · Children and/or adolescents (<18 years) without background systemic disease · 6 months, Single study (Mishra 2014); not pooled

Periodontal disease - novel loci (meta-analysis) · Adults from Japanese and European cohorts (present study + GLIDE + UK Biobank + BioBank Japan); periodontal disease… · Lifelong (germline genotype), Meta-analysis: present study + GLIDE + UKB + BBJ

Early childhood caries (ECC) · Children aged <6 years · Overall (all 24 studies; random-effects)

Secondary prevention of caries · Children and adults (with or without carious lesions) · Permanent dentition (coronal)

Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Region: America/Canada/Brazil/Chile

Use of alternative/indigenous mouth-cleaning implements · Adult residents of slums and non-slum urban settings of LMICs · Cross-sectional, Rural/slum vs urban

Enamel mineral loss · Human tooth enamel specimens, sound/intact (in vitro) · After cariogenic acid challenge / pH cycling

Streptococcus mutans mean levels/counts · Children and adolescents aged 0 to 18 years with nonsyndromic cleft lip and palate

Overall success (composite of clinical and radiographic success) · Partial pulpotomy, irreversible pulpitis

Early childhood caries (ECC) · Children aged <6 years · Confounder adjustment: Yes

Adverse effects · Children and adults (with or without carious lesions)

Primary-teeth caries experience (dmf/dmft, mean score) · Institutionalized orphan children (roughly 3 to 18 years) · Overall (pooled)

Dental caries prevalence (any dmft), dichotomous · Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts)

Rotation of the mandibular first premolar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible

Mean DFR (decayed, filled root teeth) · Adults · Overall

Spontaneous space closure · Children and adolescents with maxillary permanent first molar extraction · Follow-up to complete eruption of the permanent second molar, Maxilla

White spot lesion formation (QLF: fluorescence loss, lesion area) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35) · Before and after treatment (T0 to T1)

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (AA+GG vs GA)

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Region: North America

Incidence of new ICLs (proportion of subjects developing new lesions) · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new… · During fixed orthodontic treatment (development of new lesions), Overall (random-effects model)

Caries presence in primary teeth · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… · Children assessed at 3 yrs

dmft index score · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)

Child microbiological presence (mutans streptococci colonisation) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…

Dental caries in children · Children of mothers assessed for smoking status during pregnancy (early childhood dental caries) · Exposure during pregnancy; caries assessed in early childhood, Study region: Australia

Comparable diagnostic accuracy (photographic vs visual examination) · Overall narrative conclusion across included studies

Dental caries (prevalence) · Adults · Age 65 to over 75 years

Prevalence of ICLs (proportion of tooth surfaces affected) · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances · During or after fixed orthodontic treatment (cross-sectional/at debonding), Overall (random-effects model)

Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Study quality (NOS): low

Prevalence of ICLs (proportion of subjects affected) · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances · During or after fixed orthodontic treatment (cross-sectional/at debonding), Overall (random-effects model)

Caries arrest · Children and adults (with or without carious lesions) · 30 months, Primary dentition

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Mixed dentition

SiC30 index score · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… · Children assessed at 6 yrs

Caries arrest · Children and adults (with or without carious lesions) · 24 months, Primary dentition

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months, Full pulpotomy

Dental caries / early childhood caries (ECC) · Children (approx. 4-18 years) · Age: <7 years

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Permanent dentition

Periodontal/gingival clinical status (gingival index, biofilm index, probing depth, bleeding on probing, attachment loss) · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)

Crown caries · Adults · Crown caries

Dental caries in children · Infants and children (aged about 2 to 8 years) whose mothers' vitamin D status was assessed during pregnancy · Prenatal exposure; dental caries in children aged 2 to 8 years, Publication-bias adjustment: Trim & Fill corrected pooled estimate

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)

White spot lesion development (QLF: mineral loss, lesion area/depth, new lesions) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35) · 2 and 4 months

Dental caries (meta of mixed phenotypes: present-study self-report + GLIDE clinical DMFS + UKB self-report/dentures) · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK… · Lifelong (germline genotype), Meta-analysis: present study + GLIDE + UKB