Search review questions

Untreated dental caries (d component), continuous · Brazilian children/adolescents (BMI classified by WHO 2007 Z-score)

Child oral health behaviours · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Life expectancy: highest (>80 years)

Adverse events for mother or child · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…

Rotation of the mandibular second permanent molar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · GNI $5000-$9999

Caries presence in primary teeth · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6… · Children assessed at 2-3 yrs

Overall success (composite of clinical and radiographic success) · Mature permanent teeth with irreversible pulpitis and carious pulp exposure (treated with full pulpotomy) · >=12 months

Aesthetics · Children and adults (with or without carious lesions)

Early childhood caries (ECC) · Children aged <6 years · Sample size: ≥300

dmft index score · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… · Children assessed at 6 yrs

Streptococcus mutans count (CFU/mL) · Children and/or adolescents (<18 years) without background systemic disease · follow-up: mean 4.4 months, Overall (all presentations pooled)

Bacterial growth inhibition (MIC/MBC) · Streptococcus mutans (in vitro cultures and biofilms)

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Primary dentition

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible

Dental caries (meta of mixed phenotypes: present-study self-report + GLIDE clinical DMFS + UKB self-report/dentures) · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK… · Lifelong (germline genotype), Meta-analysis: present study + GLIDE + UKB

Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Study design: cross-sectional

Spontaneous space closure · Children and adolescents (<18 years) after extraction of a permanent first molar before eruption of the permanent… · Until eruption of the permanent second molar (median follow-up 4.0 years), Overall

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Real-time quantitative PCR genotyping

Dental pain or sensitivity · Children and adults (with or without carious lesions)

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)

Serum 25-hydroxyvitamin D level · Preschool children ≤6 years

Dental caries prevalence (DMF/dmf score > 0) · Institutionalized orphan children (roughly 3 to 18 years) · Overall (pooled)

Caries arrest · Children and adults (with or without carious lesions) · Permanent dentition

Gingival bleeding index · Children and/or adolescents (<18 years) without background systemic disease · 1.5 months, Single study (Borrell 2021); not pooled

Salivary TNF-α level (pg/mL) · Children and young adults (3-25 years)

Early childhood caries (ECC) · Preschool children ≤6 years, North America · North America

Dental caries (ECC) · Preschool children under 6 years of age · First dental examination before age 6 years, Cohort studies; sensitivity analysis excluding studies 35, 42, and 48

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months

Bacterial adhesion or initial colonization · Streptococcus mutans cultures and biofilms

Dental caries experience (DMFT), continuous · Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts)

Bacterial adhesion (inhibition) · Streptococcus mutans (in vitro cultures and biofilms)

High salivary S. mutans (over 10^4 CFU/ml) · Adults · Overall

dmft index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6… · Children assessed at 5 yrs

Overall success (composite of clinical and radiographic success) · Mature teeth, full pulpotomy, irreversible pulpitis

Oral health practices · Adults in LMIC urban and slum settings

Early childhood caries (ECC) · Children aged <6 years · Study design: Cohort

High-level S. mutans (over 10^4 CFU/ml) · Periodontitis patients · Post-treatment, Overall

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), Permanent dentition

Dental pain or sensitivity · Children and adults (with or without carious lesions)

Primary caries prevention · Children and adults (with or without carious lesions) · 24 months, Permanent dentition (coronal)

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), Real-time quantitative PCR genotyping

Child microbiological presence (mutans streptococci acquisition) · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6…

Early childhood caries (ECC) · Preschool children ≤6 years, Asia and Europe · Asia and Europe

Dental caries prevalence (any DMFT), dichotomous · Brazilian children/adolescents (BMI classified by WHO 2007 percentile)

Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Study quality (NOS): moderate

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC)

Moderate gingival inflammation / gingival health · Persons with disabilities (children and adults with autism, Down syndrome, cerebral palsy, hearing impairment, or… · Cross-sectional

Dental caries in children · Children (approx. 4-18 years) · Linear dose-response (GLST, per 1 kg/m2 BMI increment)