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Evidence found and GRADE certainty

3,556 questions · 10,375 findings · 429 reviews · Oral Health

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No studies found 1,344 · 13%GRADE not reported 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

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ARP with demineralised bone matrix, single particle size vs ARP with demineralised bone matrix, multiple particle size

Complications (e.g. discomfort, pain and swelling) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…
1 finding from 1 review

Induction chemotherapy plus locoregional treatment (radiotherapy and/or surgery) vs Locoregional treatment (radiotherapy and/or surgery) alone

Locoregional control · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Induction chemotherapy plus locoregional treatment (radiotherapy… led to lower locoregional control, induction cisplatin + 5-fluorouracil +… compared with locoregional treatment (radiotherapy and/or surgery) alone; GRADE not reported.

1 finding from 1 review

Schwarz appliance vs No active treatment (control)

Size of the lower jaw (arch length, change) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Schwarz appliance showed no clear difference in size of the lower jaw (mandibular arch length, change) at 9 months compared with no active treatment (control); GRADE not reported.

1 finding from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

Probing pocket depth · Adults (general and hospital populations assessed in case-control studies)

Probing depth is significantly increased in systemic sclerosis patients (SMD 3.10) with very high heterogeneity; certainty ungraded.

3 findings from 1 review

Radiographic imaging methods (any: analogue radiographs, digital radiographs, or CBCT) vs Reference standard (histology, excavation, or enhanced visual examination)

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
17 findings from 1 review
Show 14 more findings

Conventional bitewing radiography (E-speed film) vs Histological validation of dental tissues (gold standard)

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)

Under in vitro conditions, conventional E-speed bitewing radiography had a pooled diagnostic odds ratio of 31.40 (95% CI 14.31, 68.93) for proximal caries detection at the dentin detection level; ungraded.

4 findings from 1 review
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Visual or visual-tactile classification systems (any system: ICDAS, ERK, Nyvad, Downer, Lussi, UniViSS, or unspecified) vs Reference standard (histology, excavation, radiographs/microCT, or tooth separation)

Sensitivity for detection of enamel caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
10 findings from 1 review
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ARP with alloplast plus barrier membrane vs ARP with alloplast without membrane

Changes in vertical height of alveolar ridge (mm) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

It is very uncertain whether ARP with alloplast plus barrier membrane changes changes in vertical height of alveolar ridge (mm) compared with ARP with alloplast without membrane (very low certainty).

1 finding from 1 review

Non-selective carious tissue removal and conventional restoration (CR) vs Selective carious tissue removal (selective excavation, SE)

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…

It is very uncertain whether non-selective carious tissue removal and conventional restoration (CR) changes failure of therapy compared with selective carious tissue removal (selective excavation, SE) (very low certainty).

3 findings from 1 review

Digital bitewing radiography, phosphor plate (PSP) vs Direct visual examination after tooth separation or bioptical cavity preparation

Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo)

Under in vivo conditions, phosphor-plate digital bitewing radiography had a pooled specificity of 0.60 (95% CI 0.20, 0.90) for proximal caries detection at the dentin detection level; ungraded.

4 findings from 1 review
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Visual caries detection (ICDAS visual/visual-tactile inspection) vs Reference standard (histology, excavation, radiographs/microCT, or tooth separation)

Specificity for detection of enamel caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

Private day care vs Public day care

Dental caries prevalence · Preschool children in Sharjah day cares

Caries prevalence was 77% in private day cares versus 22% in public day cares.

2 findings from 1 review

ARP with alloplast plus barrier membrane vs ARP with alloplast without membrane

Aesthetic outcomes of future prosthodontic rehabilitation · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

The review found no eligible studies for this question.

1 finding from 1 review

Laser fluorescence (DIAGNOdent 2190/pen) vs Direct visual examination after tooth separation or bioptical cavity preparation

Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo)

Under in vivo conditions, laser fluorescence (DIAGNOdent 2190) had a pooled specificity of 0.60 (95% CI 0.15, 0.93) for proximal caries detection at the dentin detection level; ungraded.

4 findings from 1 review
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Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

Incidence of eruption of the PDC into the mouth · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

Double primary (canine and first molar) tooth extraction led to higher incidence of eruption of the PDC into the mouth compared with single primary (canine) tooth extraction; GRADE not reported.

4 findings from 1 review
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Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Diastolic blood pressure (mmHg), change from baseline · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Periodontal treatment (subgingival SRP with or without other… showed no clear difference in change in diastolic blood pressure (DBP, mmHg) compared with no treatment (no periodontal treatment) (low certainty).

4 findings from 1 review
Show 1 more finding
  • Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes
    Long term (follow-up 6 months) · People diagnosed with periodontitis and other cardiovascular diseases except hypertension
    MD -2.55 [-6.9, 1.8]
    2 studies · 103 participants
    Low