Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

17 questions · 17 findings · 15 reviews · Pain, Palliative and Supportive Care

No studies found 1 · 5.9%GRADE not reported 0 · 0%Very low 9 · 52.9%Low 3 · 17.6%Moderate 2 · 11.8%High 2 · 11.8%

Pregabalin vs placebo at end of treatment

Withdrawals due to adverse events · patients with fibromyalgia

Pregabalin leads to higher withdrawal due to adverse events compared with placebo at end of treatment (high certainty).

1 finding from 1 review

Oxycodone MR vs placebo

Withdrawals due to adverse events · adults with neuropathic pain (2 studies in peripheral diabetic neuropathy and 1 study in postherpetic neuralgia)
1 finding from 1 review

Mirtazapine vs placebo

Withdrawals due to adverse events · adults with fibromyalgia

Mirtazapine showed no clear difference in tolerability: withdrawals due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Topical clonidine (TC) vs placebo

Withdrawals due to adverse events · adults with painful diabetic neuropathy

Topical clonidine (TC) showed no clear difference in withdrawals due to adverse events during longest compared with placebo (low certainty).

1 finding from 1 review