Cochrane · systematic review · CD012182
Cannabis‐based medicines for chronic neuropathic pain in adults
Mücke, M, Phillips, T, Radbruch, L, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 4 · 57.1%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Cannabis‐based medicines compared with placebo for chronic neuropathic pain
Population: adults with chronic neuropathic pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participant‐reported pain relief of 50% or greater Cannabis‐based medicines vs placebo | no estimate extracted | 8 studies · 1001 participants | Low Downgraded: imprecision, indirectness |
Patient Global Impression of Change much or very much improved Cannabis‐based medicines vs placebo | no estimate extracted | 6 studies · 1092 participants | Very low Downgraded: inconsistency, indirectness |
Withdrawals due to adverse events Cannabis‐based medicines vs placebo | no estimate extracted | 13 studies · 1848 participants | Moderate Downgraded: indirectness |
Serious adverse events Cannabis‐based medicines vs placebo | no estimate extracted | 13 studies · 1876 participants | Low Downgraded: imprecision, indirectness |
Participant‐reported pain relief of 30% or greater Cannabis‐based medicines vs placebo | no estimate extracted | 10 studies · 1586 participants | Moderate Downgraded: indirectness |
Specific adverse events:nervous system disorder Cannabis‐based medicines vs placebo | no estimate extracted | 9 studies · 1304 participants | Low Downgraded: inconsistency, indirectness |
Specific adverse events:psychiatric disorders Cannabis‐based medicines vs placebo | no estimate extracted | 9 studies · 1314 participants | Low Downgraded: inconsistency, indirectness |