Cochrane · systematic review · CD012187
Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults
Cooper, TE, Hambleton, IR, Ballas, SK, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
8
No studies
13
Included studies
NR
No studies 13 · 61.9%Ungraded 0 · 0%Very low 8 · 38.1%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Non‐steroidal anti‐inflammatory drugs (NSAID) compared with placebo for painful sickle cell vaso‐occlusive crises
Population: adults with sickle cell disease in a vaso‐occlusive crises
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participant‐reported pain relief of 50% or greater Non‐steroidal anti‐inflammatory drugs (NSAID) vs placebo | no estimate extracted | NR | No studies |
Participant‐reported pain relief of 30% or greater Non‐steroidal anti‐inflammatory drugs (NSAID) vs placebo | no estimate extracted | NR | No studies |
PGIC very much improved ( Non‐steroidal anti‐inflammatory drugs (NSAID) vs placebo | RR 7.64 [0.44, 131.75] | 1 study · 21 participants | Very low |
PGIC much or very much improved ( Non‐steroidal anti‐inflammatory drugs (NSAID) vs placebo | RR 1.65 [0.65, 4.19] | 1 study · 21 participants | Very low |
Any adverse event ( Non‐steroidal anti‐inflammatory drugs (NSAID) vs placebo | no estimate extracted | 2 studies · 72 participants | Very low |
Serious adverse events ( Non‐steroidal anti‐inflammatory drugs (NSAID) vs placebo | no estimate extracted | 3 studies · 93 participants | Very low |
Withdrawals due to adverse events ( Non‐steroidal anti‐inflammatory drugs (NSAID) vs placebo | no estimate extracted | 3 studies · 93 participants | Very low |
Opioids compared with placebo for painful sickle cell vaso‐occlusive crises
Population: adults with sickle cell disease in a vaso‐occlusive crisis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participant‐reported pain relief of 50% or greater Opioids vs placebo | no estimate extracted | NR | No studies |
Participant‐reported pain relief of 30% or greater Opioids vs placebo | no estimate extracted | NR | No studies |
PGIC very much improved Opioids vs placebo | no estimate extracted | NR | No studies |
PGIC much or very much improved Opioids vs placebo | no estimate extracted | NR | No studies |
Any adverse event Opioids vs placebo | no estimate extracted | NR | No studies |
Serious adverse event Opioids vs placebo | no estimate extracted | NR | No studies |
Withdrawals due to adverse events Opioids vs placebo | no estimate extracted | NR | No studies |
Opioids compared with active comparator for painful sickle cell vaso‐occlusive crises
Population: adults with sickle cell disease in a vaso‐occlusive crisis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participant‐reported pain relief of 50% or greater Opioids vs active comparator | no estimate extracted | NR | No studies |
Participant‐reported pain relief of 30% or greater Opioids vs active comparator | no estimate extracted | NR | No studies |
PGIC very much improved ( Opioids vs active comparator | no estimate extracted | 1 study · 18 participants | Very low |
PGIC much or very much improved Opioids vs active comparator | no estimate extracted | NR | No studies |
Any adverse event ( Opioids vs active comparator | no estimate extracted | 2 studies · 124 participants | Very low |
Serious adverse event ( Opioids vs active comparator | no estimate extracted | 2 studies · 124 participants | Very low |
Withdrawals due to adverse events Opioids vs active comparator | no estimate extracted | NR | No studies |