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What do systematic reviews say?

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Evidence found and GRADE certainty

80 questions · 80 findings · 48 reviews · Pregnancy and Childbirth

No studies found 4 · 5%GRADE not reported 5 · 6.3%Very low 11 · 13.8%Low 32 · 40%Moderate 14 · 17.5%High 14 · 17.5%

Intramuscular (IM) progesterone vs no treatment or placebo

Preterm birth less than 34 weeks' gestation · Women with a multiple pregnancy

Intramuscular (IM) progesterone may leads to higher preterm birth less than 34 weeks compared with no treatment or placebo (low certainty).

1 finding from 1 review

Intramuscular (IM) progesterone vs no treatment or placebo

Preterm birth less than 28 weeks · Women with a multiple pregnancy

Intramuscular (IM) progesterone showed no clear difference in preterm birth less than 28 weeks compared with no treatment or placebo (moderate certainty).

1 finding from 1 review

Acupuncture vs placebo

Preterm birth · Pregnant women with hyperemesis gravidarum

Acupuncture showed no clear difference in preterm birth less than 37 weeks compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Any preterm birth (birth < 37 weeks) · women with a previous stillbirth of > 20 weeks' gestation who are pregnant or considering a subsequent pregnancy

It is very uncertain whether the intervention changes any preterm birth (birth < 37 weeks) (very low certainty).

1 finding from 1 review

Intervention not reported

Any preterm birth (birth < 37 weeks) · women with a previous stillbirth of ≥ 20 weeks' gestation who are pregnant or considering a subsequent pregnancy

The intervention showed no clear difference in any preterm birth (birth < 37 weeks) (low certainty).

1 finding from 1 review

Intervention not reported

Preterm birth (< 37 weeks' gestation) · All pregnant women receiving either vitamin C supplementation or control either in areas where there is inadequate dietary intake or where…

The intervention showed no clear difference in preterm birth (< 37 weeks' gestation) (high certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo or no intervention

Gestational age (preterm birth < 37 weeks) · healthy pregnant women receiving calcium supplementation vs placebo or no treatment

Calcium supplementation showed no clear difference in preterm birth (a) Birth prior to 37 weeks compared with placebo or no treatment (maternal outcomes) (moderate certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo or no intervention

Preterm birth less than 34 weeks' gestation · healthy pregnant women receiving calcium supplementation vs placebo or no treatment

Calcium supplementation showed no clear difference in preterm birth (b) Birth prior to 34 weeks compared with placebo or no treatment (maternal outcomes) (moderate certainty).

1 finding from 1 review

Intervention not reported

Preterm birth (before 37 weeks' gestation) · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower preterm birth (before 37 weeks' gestation) (high certainty).

1 finding from 1 review

Intervention not reported

Preterm birth less than 34 weeks' gestation · women undergoing home monitoring for preventing preterm birth versus women receiving standard care

The intervention leads to lower preterm birth less than 34 weeks' gestation (high certainty).

1 finding from 1 review

Intervention not reported

Preterm birth less than 37 weeks' gestation · women undergoing home monitoring for preventing preterm birth versus women receiving standard care

It is very uncertain whether the intervention changes preterm birth less than 37 weeks' gestation (very low certainty).

1 finding from 1 review

Vitamin D + calcium + other vitamins and minerals vs calcium + other vitamins and minerals (but no vitamin D)

Preterm birth · pregnant women and their infants..

Vitamin D + calcium + other vitamins and minerals showed no clear difference in preterm birth (less than 37 weeks' gestation) compared with calcium + other vitamins and minerals (but no vitamin D) (low certainty).

1 finding from 1 review