Cochrane · systematic review · CD008873
Vitamin D supplementation for women during pregnancy
Palacios, C, Kostiuk, LK, Peña‐Rosas, JP · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
18
current version
GRADE rated
16
No studies
1
Included studies
NR
No studies 1 · 5.6%Ungraded 1 · 5.6%Very low 6 · 33.3%Low 6 · 33.3%Moderate 4 · 22.2%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 3 versionsVitamin D supplementation compared to placebo or no intervention for pregnancy and neonatal health outcomes
Population: pregnant women and their infants.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pre‐eclampsia Vitamin D supplementation vs placebo or no intervention | RR 0.48 [0.3, 0.79] | 4 studies · 499 participants | Moderate Downgraded: risk of bias |
Gestational diabetes Vitamin D supplementation vs placebo or no intervention | RR 0.51 [0.27, 0.97] | 4 studies · 446 participants | Moderate Downgraded: risk of bias, imprecision |
Maternal adverse events: severe postpartum haemorrhage Vitamin D supplementation vs placebo or no intervention | RR 0.68 [0.51, 0.91] | 1 study · 1134 participants | Low Downgraded: risk of bias, imprecision |
Maternal adverse event: nephritic syndrome Vitamin D supplementation vs placebo or no intervention | RR 0.17 [0.01, 4.06] | 1 study · 135 participants | Very low Downgraded: risk of bias, imprecision |
Maternal adverse event: hypercalcaemia Vitamin D supplementation vs placebo or no intervention | no estimate extracted | 1 study · 1134 participants | Low Downgraded: risk of bias, imprecision |
Preterm birth (less than 37 weeks' gestation) Vitamin D supplementation vs placebo or no intervention | RR 0.66 [0.34, 1.3] | 7 studies · 1640 participants | Low Downgraded: risk of bias, imprecision |
Low birthweight (less than 2500 g) Vitamin D supplementation vs placebo or no intervention | RR 0.55 [0.35, 0.87] | 5 studies · 697 participants | Moderate Downgraded: risk of bias, imprecision |
Vitamin D + calcium supplementation compared to placebo or no intervention for pregnancy and neonatal health outcomes
Population: pregnant women and their infants..
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pre‐eclampsia Vitamin D + calcium supplementation vs placebo or no intervention | RR 0.5 [0.32, 0.78] | 4 studies · 1174 participants | Moderate Downgraded: risk of bias, imprecision |
Gestational diabetes Vitamin D + calcium supplementation vs placebo or no intervention | RR 0.33 [0.01, 7.84] | 1 study · 54 participants | Very low Downgraded: risk of bias, imprecision |
Maternal adverse events Vitamin D + calcium supplementation vs placebo or no intervention | no estimate extracted | NR | No studies |
Preterm birth (less than 37 weeks' gestation) Vitamin D + calcium supplementation vs placebo or no intervention | RR 1.52 [1.01, 2.28] | 5 studies · 942 participants | Low Downgraded: risk of bias, imprecision |
Low birthweight (less than 2500 g) Vitamin D + calcium supplementation vs placebo or no intervention | RR 0.68 [0.1, 4.55] | 2 studies · 110 participants | Very low Downgraded: risk of bias, imprecision |
Vitamin D + calcium + other vitamins and minerals compared to calcium + other vitamins and minerals (but no vitamin D) for pregnancy and neonatal health outcomes
Population: pregnant women and their infants..
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pre‐eclampsia Vitamin D + calcium + other vitamins and minerals vs calcium + other vitamins and minerals (but no vitamin D) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Gestational diabetes Vitamin D + calcium + other vitamins and minerals vs calcium + other vitamins and minerals (but no vitamin D) | RR 0.42 [0.1, 1.73] | 1 study · 1298 participants | Very low Downgraded: risk of bias, imprecision |
Maternal adverse event: hypercalcaemia Vitamin D + calcium + other vitamins and minerals vs calcium + other vitamins and minerals (but no vitamin D) | no estimate extracted | 1 study · 1298 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Maternal adverse event: hypercalciuria Vitamin D + calcium + other vitamins and minerals vs calcium + other vitamins and minerals (but no vitamin D) | no estimate extracted | 1 study · 1298 participants | Very low Downgraded: risk of bias, imprecision |
Preterm birth (less than 37 weeks' gestation) Vitamin D + calcium + other vitamins and minerals vs calcium + other vitamins and minerals (but no vitamin D) | RR 1.04 [0.68, 1.59] | 1 study · 1298 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Low birthweight (less than 2500 g) Vitamin D + calcium + other vitamins and minerals vs calcium + other vitamins and minerals (but no vitamin D) | RR 1.12 [0.82, 1.51] | 1 study · 1298 participants | Low Downgraded: risk of bias, imprecision, indirectness |