Cochrane · systematic review · CD012203
Care prior to and during subsequent pregnancies following stillbirth for improving outcomes
Wojcieszek, AM, Shepherd, E, Middleton, P, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
11
No studies
3
Included studies
NR
No studies 3 · 21.4%Ungraded 0 · 0%Very low 6 · 42.9%Low 5 · 35.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: women with a previous stillbirth of ≥ 20 weeks' gestation who are pregnant or considering a subsequent pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Stillbirth | RR 2.58 [0.4, 16.62] | 3 studies · 122 participants | Low Downgraded: imprecision |
Neonatal death | no estimate extracted | 3 studies · 122 participants | Low Downgraded: imprecision |
Adverse perinatal outcome (composite outcome including stillbirth, neonatal death, and major neonatal morbidity) | RR 0.81 [0.2, 3.32] | 2 studies · 77 participants | Low Downgraded: imprecision, inconsistency |
Adverse maternal psychological effects (anxiety, depression or complicated grief) | RR 1 [0.07, 14.9] | 1 study · 40 participants | Very low Downgraded: imprecision, inconsistency |
Perinatal mortality | RR 2.58 [0.4, 16.62] | 3 studies · 122 participants | Low Downgraded: imprecision |
Any preterm birth (birth < 37 weeks) | RR 1.01 [0.58, 1.74] | 3 studies · 114 participants | Low Downgraded: imprecision, inconsistency |
Maternal‐infant attachment ‐ not measured | no estimate extracted | NR | No studies |
Comparison
Population: women with a previous stillbirth of > 20 weeks' gestation who are pregnant or considering a subsequent pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Stillbirth | RR 0.85 [0.06, 12.01] | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Neonatal death | RR 0.29 [0.01, 6.38] | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse perinatal outcome (composite outcome including stillbirth, neonatal death, and major neonatal morbidity) | RR 0.28 [0.03, 2.34] | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse maternal psychological effects (anxiety, depression or complicated grief) ‐ not measured | no estimate extracted | NR | No studies |
Perinatal mortality | RR 0.42 [0.04, 4.06] | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Any preterm birth (birth < 37 weeks) | RR 0.42 [0.04, 4.06] | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Maternal‐infant attachment ‐ not measured | no estimate extracted | NR | No studies |