Cochrane · systematic review · CD004659
Antiplatelet agents for preventing pre‐eclampsia and its complications
Duley, L, Meher, S, Hunter, KE, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 28.6%High 5 · 71.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: pregnant women considered to be at risk of developing pre‐eclampsia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proteinuric pre‐eclampsia | RR 0.82 [0.77, 0.88] | 60 studies · 36716 participants | High |
Any reported infant death (fetal, neonatal, or before hospital discharge | RR 0.85 [0.76, 0.95] | 52 studies · 35391 participants | High |
Preterm birth (before 37 weeks' gestation) | RR 0.91 [0.87, 0.95] | 47 studies · 35212 participants | High |
Small‐for‐gestational age | RR 0.84 [0.76, 0.92] | 50 studies · 35761 participants | High |
Pregnancy with serious adverse outcome (composite including maternal death, baby death, pre‐eclampsia, small‐for‐gestational age, preterm birth) ‐ only trials with individual participant data | RR 0.9 [0.85, 0.96] | 13 studies · 17382 participants | High |
Postpartum haemorrhage > 500 mL | RR 1.06 [1, 1.12] | 19 studies · 23769 participants | Moderate Downgraded: imprecision, inconsistency |
Placental abruption | RR 1.21 [0.95, 1.54] | 29 studies · 30775 participants | Moderate Downgraded: imprecision, inconsistency |