Cochrane · systematic review · CD004072
Vitamin C supplementation in pregnancy
Rumbold, A, Ota, E, Nagata, C, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 16.7%Moderate 2 · 33.3%High 3 · 50%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Vitamin C supplementation alone or in combination with other supplements (all trials)
Population: All pregnant women receiving either vitamin C supplementation or control either in areas where there is inadequate dietary intake or where there is presumed adequate intake.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Stillbirth | RR 1.15 [0.89, 1.49] | 11 studies · 20038 participants | Moderate Downgraded: imprecision |
Intrauterine growth restriction | RR 0.98 [0.91, 1.06] | 12 studies · 20361 participants | High |
Preterm birth (< 37 weeks' gestation) | RR 0.99 [0.9, 1.1] | 16 studies · 22250 participants | High |
Preterm prelabour rupture of membranes | RR 0.98 [0.7, 1.36] | 10 studies · 16825 participants | Low Downgraded: imprecision, inconsistency |
Clinical pre‐eclampsia | RR 0.92 [0.8, 1.05] | 16 studies · 21956 participants | Moderate Downgraded: publication bias |
Placental abruption | RR 0.64 [0.44, 0.92] | 8 studies · 15755 participants | High |