Findings

What do systematic reviews say?

27 questions · 27 findings · 16 reviews · Pain, Palliative and Supportive Care

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No studies found 11 · 40.7%GRADE not reported 0 · 0%Very low 10 · 37%Low 2 · 7.4%Moderate 3 · 11.1%High 1 · 3.7%

Pregabalin 600 mg vs placebo

Patient Global Impression of Change much or very much improved · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Pregabalin 300 mg vs placebo

Patient Global Impression of Change much or very much improved · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1050 participants
Moderate

Pregabalin 300 mg vs placebo

PGIC very much improved · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 501 participants
Low

Pregabalin 600 mg vs placebo

Patient Global Impression of Change much or very much improved · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 537 participants
Moderate

Pregabalin 300 mg vs placebo

Patient Global Impression of Change much or very much improved · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 568 participants
Low

Pregabalin vs placebo

Patient Global Impression of Change much or very much improved · children and adolescents with chronic non‐cancer pain

1 finding from 1 review

Antiepileptic drugs for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 107 participants
Very low

Pregabalin vs placebo at end of treatment

Patient Global Impression of Change much or very much improved · patients with fibromyalgia

Pregabalin leads to higher patient Global Impression of Change of 'much' or 'very much' improved compared with placebo at end of treatment (high certainty).

1 finding from 1 review

Anticonvulsants for fibromyalgia 2013 · Cochrane Headline outcomes only
RR 1.38 [1.23, 1.55]
5 studies · 3183 participants
High

Citalopram vs placebo

Patient Global Impression of Change much or very much improved · children (4 to 18 years) with functional abdominal pain disorders

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressants for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Amitriptyline vs gabapentin

Patient Global Impression of Change much or very much improved · children and adolescents with chronic non‐cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressants for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Amitriptyline vs placebo

Patient Global Impression of Change much or very much improved · children and adolescents with chronic non‐cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressants for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Cannabis‐based medicines vs placebo

Patient Global Impression of Change much or very much improved · adults with chronic neuropathic pain

1 finding from 1 review

Cannabis‐based medicines for chronic neuropathic pain in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1092 participants
Very low

Gabapentin vs placebo

Patient Global Impression of Change much or very much improved · adults with postherpetic neuralgia

1 finding from 1 review

Gabapentin for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 2013 participants
Moderate

Gabapentin vs amitriptyline

Patient Global Impression of Change much or very much improved · children and adolescents with chronic non‐cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Antiepileptic drugs for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Rofecoxib vs naproxen

Patient Global Impression of Change much or very much improved · children and adolescents with chronic non‐cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Meloxicam vs naproxen

Patient Global Impression of Change much or very much improved · children and adolescents with chronic non‐cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Celecoxib vs naproxen

Patient Global Impression of Change much or very much improved · children and adolescents with chronic non‐cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Patient Global Impression of Change much or very much improved · adults with fibromyalgia

The review found no eligible studies for this question.

1 finding from 1 review

Antipsychotics for fibromyalgia in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Patient Global Impression of Change much or very much improved · adults with neuropathic pain (Trigeminal neuralgia, painful diabetic neuropathy, chronic post stroke pain)

1 finding from 1 review

Carbamazepine for chronic neuropathic pain and fibromyalgia in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Patient Global Impression of Change much or very much improved · Adults with cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Codeine, alone and with paracetamol (acetaminophen), for cancer pain 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Patient Global Impression of Change much or very much improved · neuropathic pain (5 studies in painful diabetic neuropathy and polyneuropathy)

1 finding from 1 review

Imipramine for neuropathic pain in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low