Cochrane Review Group

Eyes and Vision

171 systematic reviews in Eyes and Vision ask 2,112 questions. 27.8% have no studies to answer them, 21.1% rest on very low certainty evidence and 20.2% reach moderate or high certainty.

Reviews

171

Questions

2,112

current versions

No studies

27.8%

Moderate or high

20.2%

No studies 587 · 27.8%Ungraded 95 · 4.5%Very low 446 · 21.1%Low 557 · 26.4%Moderate 361 · 17.1%High 66 · 3.1%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Eyes and Vision

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
LipiFlow vs basic warm compresses Mean change from baseline in symptom scores at 1 to 4 weeks (lower is favored) · people with dry eye LipiFlow for the treatment of dry eye disease (2024) · Cochrane	no estimate extracted	NR	Very low
LipiFlow vs thermostatic devices Proportion of participants with intervention‐related, vision‐threatening adverse events at 1 to 4 weeks · people with dry eye LipiFlow for the treatment of dry eye disease (2024) · Cochrane	no estimate extracted	4 studies · 445 participants	Very low
LipiFlow vs basic warm compresses Mean change from baseline in meibomian gland expression scores at 1 to 4 weeks (higher is favored) · people with dry eye LipiFlow for the treatment of dry eye disease (2024) · Cochrane	SMD 1.31	2 studies · 76 participants	Very low
LipiFlow vs basic warm compresses Mean change from baseline in meibum quality scores at 1 to 4 weeks (higher is favored) · people with dry eye LipiFlow for the treatment of dry eye disease (2024) · Cochrane	no estimate extracted	1 study · 46 participants	Very low
LipiFlow vs thermostatic devices Mean change from baseline in symptom scores at 1 to 4 weeks (lower is favored) · people with dry eye LipiFlow for the treatment of dry eye disease (2024) · Cochrane	no estimate extracted	NR	Very low
Face‐down positioning vs other positioning Proportion of eyes with retinal displacement at 6 months or later (RR < 1 favored) · people with primary macula‐involving rhegmatogenous retinal detachments Face‐down positioning or posturing after pars plana vitrectomy for macula‐involving rhegmatogenous retinal… (2024) · Cochrane	RR 0.73 [0.54, 0.99]	1 study · 239 participants	Very low
Face‐down positioning vs other positioning Mean change in logMAR or Snellen visual acuity from baseline to 3 months or later (lower is favored) · people with primary macula‐involving rhegmatogenous retinal detachments Face‐down positioning or posturing after pars plana vitrectomy for macula‐involving rhegmatogenous retinal… (2024) · Cochrane	no estimate extracted	1 study · 56 participants	Very low
Face‐down positioning vs other positioning Mean objective distortion score at 3 months or later (lower is favored) · people with primary macula‐involving rhegmatogenous retinal detachments Face‐down positioning or posturing after pars plana vitrectomy for macula‐involving rhegmatogenous retinal… (2024) · Cochrane	MD 1.8	1 study · 219 participants	Very low
Face‐down positioning vs other positioning Quality of life assessments at 3 months or later (higher is favored) · people with primary macula‐involving rhegmatogenous retinal detachments Face‐down positioning or posturing after pars plana vitrectomy for macula‐involving rhegmatogenous retinal… (2024) · Cochrane	no estimate extracted	1 study · 217 participants	Very low
Face‐down positioning vs other positioning Frequency of intervention‐related ocular adverse events ( · people with primary macula‐involving rhegmatogenous retinal detachments Face‐down positioning or posturing after pars plana vitrectomy for macula‐involving rhegmatogenous retinal… (2024) · Cochrane	no estimate extracted	1 study · 262 participants	Very low
Face‐down positioning vs other positioning Frequency of intervention‐related non‐ocular adverse events ( · people with primary macula‐involving rhegmatogenous retinal detachments Face‐down positioning or posturing after pars plana vitrectomy for macula‐involving rhegmatogenous retinal… (2024) · Cochrane	no estimate extracted	NR	No studies
Lutein with or without zeaxanthin vs placebo Adverse effects · people with AMD Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration (2023) · Cochrane	OR 1.06	NR	Very low

Reviews 171

Antimetabolites as an adjunct to dacryocystorhinostomy for nasolacrimal duct obstruction

Phelps, PO, Abariga, SA, et al. · Cochrane Database of Systematic Reviews · 2020

Eyes and Vision

Thinnest evidence

Reviews 171

Antimetabolites as an adjunct to dacryocystorhinostomy for nasolacrimal duct obstruction

Wavefront excimer laser refractive surgery for adults with refractive errors

Ab interno trabecular bypass surgery with Schlemm´s canal microstent (Hydrus) for open angle glaucoma

Laser‐assisted in‐situ keratomileusis (LASIK) with a mechanical microkeratome compared to LASIK with a femtosecond laser for LASIK in adults with myopia or myopic astigmatism

Non‐contact tests for identifying people at risk of primary angle closure glaucoma

Corneal collagen cross‐linking for bacterial infectious keratitis

Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to age‐related macular degeneration

Tea tree oil for Demodex blepharitis

Intense pulsed light (IPL) therapy for the treatment of meibomian gland dysfunction

Antibiotics for trachoma

Anti‐vascular endothelial growth factor for neovascular age‐related macular degeneration

Conventional occlusion versus pharmacologic penalization for amblyopia

Routine preoperative medical testing for cataract surgery

Pars plana vitrectomy versus scleral buckling for repairing simple rhegmatogenous retinal detachments

Topical cyclosporine A therapy for dry eye syndrome

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease

Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma

Cyclodestructive procedures for refractory glaucoma

Types of materials for frontalis sling surgery for congenital ptosis

Ab interno trabecular bypass surgery with iStent for open‐angle glaucoma

Toric intraocular lens versus limbal relaxing incisions for corneal astigmatism after phacoemulsification

Interventions for recurrent corneal erosions

Reading aids for adults with low vision

Adjustable versus non‐adjustable sutures for strabismus

Vision screening for correctable visual acuity deficits in school‐age children and adolescents