Cochrane · systematic review · CD010051
Topical cyclosporine A therapy for dry eye syndrome
de Paiva, CS, Pflugfelder, SC, Ng, SM, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 7 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Topical cyclosporine A 0.05% + artificial tears versus vehicle + artificial tears or artificial tears alone for dry eye syndrome
Population: People with dry eye syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Subjective symptoms of dry eye at 6 months Topical cyclosporine A 0.05% + artificial tears vs vehicle + artificial tears or artificial tears alone | no estimate extracted | 1 study · 56 participants | Low Downgraded: risk of bias, imprecision |
Ocular surface dye staining at 6 months Topical cyclosporine A 0.05% + artificial tears vs vehicle + artificial tears or artificial tears alone | no estimate extracted | 2 studies · 291 participants | Low Downgraded: risk of bias, inconsistency |
Aqueous tear production measured by Schirmer test scores (mm/5 minutes) at 6 months Topical cyclosporine A 0.05% + artificial tears vs vehicle + artificial tears or artificial tears alone | no estimate extracted | 4 studies · 406 participants | Low Downgraded: risk of bias, inconsistency |
Tear film stability measured by tear break‐up time (seconds) at 6 months Topical cyclosporine A 0.05% + artificial tears vs vehicle + artificial tears or artificial tears alone | no estimate extracted | 5 studies · 676 participants | Low Downgraded: risk of bias, inconsistency |
Frequency of artificial tear usage at 6 months Topical cyclosporine A 0.05% + artificial tears vs vehicle + artificial tears or artificial tears alone | no estimate extracted | 3 studies · 910 participants | Low Downgraded: risk of bias, inconsistency |
Conjunctival goblet cell density (cells per unit) at 6 months Topical cyclosporine A 0.05% + artificial tears vs vehicle + artificial tears or artificial tears alone | no estimate extracted | 2 studies · 100 participants | Low Downgraded: risk of bias, imprecision |
Treatment related adverse events, Topical cyclosporine A 0.05% + artificial tears vs vehicle + artificial tears or artificial tears alone | no estimate extracted | 3 studies · 743 participants | Low Downgraded: risk of bias, imprecision |