Cochrane · systematic review · CD012743
Ab interno trabecular bypass surgery with iStent for open‐angle glaucoma
Le, JT, Bicket, AK, Wang, L, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
5
No studies
4
Included studies
NR
No studies 4 · 28.6%Ungraded 5 · 35.7%Very low 5 · 35.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
IStent in combination with phacoemulsification compared to phacoemulsification alone for open‐angle glaucoma
Population: open‐angle glaucoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of participants who were drop‐free IStent in combination with phacoemulsification vs phacoemulsification alone | RR 1.38 [1.18, 1.63] | 2 studies · 239 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Mean change in number of IOP‐lowering drops from baseline IStent in combination with phacoemulsification vs phacoemulsification alone | no estimate extracted | 2 studies · 282 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Mean change in IOP from baseline IStent in combination with phacoemulsification vs phacoemulsification alone | no estimate extracted | 3 studies · 284 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Health‐related quality of life IStent in combination with phacoemulsification vs phacoemulsification alone | no estimate extracted | NR | No studies |
Intraoperative complications IStent in combination with phacoemulsification vs phacoemulsification alone | no estimate extracted | NR | No studies |
Postoperative complications IStent in combination with phacoemulsification vs phacoemulsification alone | no estimate extracted | 4 studies · 334 participants | Ungraded |
Secondary glaucoma surgery IStent in combination with phacoemulsification vs phacoemulsification alone | no estimate extracted | 3 studies · 290 participants | Ungraded |
IStent (or iStent inject) compared to medical therapy for open‐angle glaucoma
Population: open‐angle glaucoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of participants who were drop‐free IStent (or iStent inject) vs medical therapy | no estimate extracted | 2 studies · 286 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Mean change in number of IOP‐lowering drops from baseline IStent (or iStent inject) vs medical therapy | no estimate extracted | NR | No studies |
Mean change in IOP from baseline IStent (or iStent inject) vs medical therapy | no estimate extracted | 1 study · 184 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Health‐related quality of life IStent (or iStent inject) vs medical therapy | no estimate extracted | NR | No studies |
Intraoperative complications IStent (or iStent inject) vs medical therapy | no estimate extracted | 1 study · 101 participants | Ungraded |
Postoperative complications IStent (or iStent inject) vs medical therapy | no estimate extracted | 2 studies · 286 participants | Ungraded |
Secondary glaucoma surgery IStent (or iStent inject) vs medical therapy | no estimate extracted | 2 studies · 286 participants | Ungraded |