Cochrane · systematic review · CD012309
Antimetabolites as an adjunct to dacryocystorhinostomy for nasolacrimal duct obstruction
Phelps, PO, Abariga, SA, Cowling, BJ, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 66.7%Moderate 2 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Mitomycin C dacryocystorhinostomy compared to dacryocystorhinostomy alone for nasolacrimal duct obstruction
Population: nasolacrimal duct obstruction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Functional success, defined as the relief of epiphora Mitomycin C dacryocystorhinostomy vs dacryocystorhinostomy alone | RR 1.12 [0.98, 1.29] | 7 studies · 356 participants | Low Downgraded: risk of bias, imprecision |
Functional success, defined as the relief of epiphora Mitomycin C dacryocystorhinostomy vs dacryocystorhinostomy alone | RR 1.15 [1.07, 1.25] | 14 studies · 909 participants | Moderate Downgraded: risk of bias |
Anatomic success, defined as patency to lacrimal irrigation Mitomycin C dacryocystorhinostomy vs dacryocystorhinostomy alone | RR 1.02 [0.95, 1.11] | 4 studies · 306 participants | Low Downgraded: risk of bias, imprecision |
Anatomic success, defined as patency to lacrimal irrigation Mitomycin C dacryocystorhinostomy vs dacryocystorhinostomy alone | RR 1.09 [1.04, 1.15] | 12 studies · 831 participants | Moderate Downgraded: risk of bias |
Ostium size on nasal endoscopy Mitomycin C dacryocystorhinostomy vs dacryocystorhinostomy alone | mean difference 3.7 | 2 studies · 65 participants | Low Downgraded: risk of bias, inconsistency |
Ostium size on nasal endoscopy at Mitomycin C dacryocystorhinostomy vs dacryocystorhinostomy alone | MD 1.4 | 2 studies · 100 participants | Low Downgraded: risk of bias, inconsistency |