Cochrane · systematic review · CD012740
Ab interno trabecular bypass surgery with Schlemm´s canal microstent (Hydrus) for open angle glaucoma
Otarola, F, Virgili, G, Shah, A, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
10
No studies
4
Included studies
NR
No studies 4 · 28.6%Ungraded 0 · 0%Very low 1 · 7.1%Low 6 · 42.9%Moderate 3 · 21.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Cataract surgery with Hydrus microstent compared to cataract surgery alone
Population: people with cataracts and open angle glaucoma, many of whom had mild or moderate glaucoma, which was well‐controlled with medication
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of participants who were medication‐free (not using eye drops) medium‐term Cataract surgery with Hydrus microstent vs cataract surgery alone | RR 1.63 [1.4, 1.88] | 2 studies · 619 participants | Moderate Downgraded: risk of bias |
Mean change in unmedicated IOP (after washout) measured using Goldmann applanation tonometry medium‐term Cataract surgery with Hydrus microstent vs cataract surgery alone | no estimate extracted | 2 studies · 619 participants | Moderate Downgraded: risk of bias |
Mean change in the number of IOP‐lowering drops instilled per day medium‐term Cataract surgery with Hydrus microstent vs cataract surgery alone | no estimate extracted | 2 studies · 619 participants | Low Downgraded: risk of bias, indirectness |
Proportion of participants who required further glaucoma surgery, including laser Cataract surgery with Hydrus microstent vs cataract surgery alone | RR 0.17 [0.03, 0.86] | 2 studies · 619 participants | Low Downgraded: risk of bias, imprecision |
Visual field progression Cataract surgery with Hydrus microstent vs cataract surgery alone | no estimate extracted | NR | No studies |
Mean change in health‐related quality of life Cataract surgery with Hydrus microstent vs cataract surgery alone | no estimate extracted | NR | No studies |
Proportion of participants experiencing intraoperative or postoperative complications medium‐term Cataract surgery with Hydrus microstent vs cataract surgery alone | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision |
Hydrus microstent compared to iStent trabecular micro‐bypass stent
Population: people with open angle glaucoma, many of whom had mild or moderate glaucoma, which was well‐controlled with medication
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of participants who were medication‐free (not using eye drops) short‐term Hydrus microstent vs iStent trabecular micro‐bypass stent | RR 1.94 [1.21, 3.11] | 1 study · 148 participants | Low |
Mean change in unmedicated IOP (after washout) measured using Goldmann applanation tonometry short‐term Hydrus microstent vs iStent trabecular micro‐bypass stent | no estimate extracted | 1 study · 148 participants | Moderate |
Mean change in number of IOP‐lowering drops instilled per day short‐term Hydrus microstent vs iStent trabecular micro‐bypass stent | no estimate extracted | 1 study · 148 participants | Low |
Proportion of participants who required further glaucoma surgery, including laser Hydrus microstent vs iStent trabecular micro‐bypass stent | no estimate extracted | 1 study · 148 participants | Very low Downgraded: imprecision |
Visual field progression Hydrus microstent vs iStent trabecular micro‐bypass stent | no estimate extracted | NR | No studies |
Mean change in health‐related quality of life Hydrus microstent vs iStent trabecular micro‐bypass stent | no estimate extracted | NR | No studies |
Proportion of participants experiencing intraoperative or postoperative complications short‐term Hydrus microstent vs iStent trabecular micro‐bypass stent | no estimate extracted | 1 study · 148 participants | Low Downgraded: imprecision |